A5027346248- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- COVID-19 and Mental Health
- Antifungal resistance and susceptibility
- Bacteriophages and microbial interactions
- Streptococcal Infections and Treatments
- Microbial infections and disease research
- Pneumonia and Respiratory Infections
- Blood disorders and treatments
- Bacterial Identification and Susceptibility Testing
- Fungal Infections and Studies
- COVID-19 Impact on Reproduction
- Education Practices and Challenges
- Bacterial Infections and Vaccines
- Parvovirus B19 Infection Studies
- COVID-19 diagnosis using AI
- Immunodeficiency and Autoimmune Disorders
- Long-Term Effects of COVID-19
- Liver Disease and Transplantation
- Pneumocystis jirovecii pneumonia detection and treatment
- Helminth infection and control
- RNA regulation and disease
- Clinical Nutrition and Gastroenterology
- Parasites and Host Interactions
Cliniques Universitaires Saint-Luc
2015-2024
UCLouvain
2020-2024
Instituut voor Tropische Geneeskunde
2022
Federation University
2022
CHU Dinant Godinne UCL Namur
2022
University Hospital of Geneva
2018-2020
University of Geneva
2018
Geneva College
2018
Abstract In contrast to the many reports of successful real-world cases personalized bacteriophage therapy (BT), randomized controlled trials non-personalized products have not produced expected results. Here we present outcomes a retrospective observational analysis first 100 consecutive BT difficult-to-treat infections facilitated by Belgian consortium in 35 hospitals, 29 cities and 12 countries during period from 1 January 2008 30 April 2022. We assessed how often positive clinical...
Abstract Post-operative bacterial infections are a leading cause of mortality and morbidity after ongoing liver transplantation. Bacteria causing these in the hospital setting can exhibit high degrees resistance to multiple types antibiotics, which leads major therapeutic hurdles. Alternate ways treating antibiotic-resistant thus urgently needed. Phage therapy is one them consists using selected bacteriophage viruses – who specifically prey on bacteria, naturally found various environmental...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December, 2019, Wuhan, China, and has spread all over the world. This virus is responsible for a range of clinical manifestations adults children, ranging from mild symptoms to severe distress (ARDS) with radiological signs bilateral pneumonia.1Zhu N Zhang D Wang W et al.A novel patients pneumonia 2019.N Engl J Med. 2020; 382: 727-733Crossref PubMed Scopus (18869) Google Scholar Mortality rates between 0·12% paediatric...
Abstract Background There is lack of recent multicenter epidemiological data on invasive aspergillosis ( IA ) among solid organ transplant recipient SOT r) in the mold‐acting antifungal era. We describe epidemiology and outcomes a contemporary cohort r using Swiss Transplant Cohort Study. Methods All consecutive with proven or probable between 01.05.2008 31.12.2014 were included. A case‐control study to identify predictors was performed: 1‐case matched 3‐controls based type, center, time...
Respiratory syncytial virus (RSV) is associated with significant mortality rates amongst hematopoietic stem cell transplant (HSCT) recipients, less known about other immunocompromised patients. Ten-year retrospective cohort study of patients presenting RSV disease documented at University Hospitals Lausanne and Geneva. Severe RSV-related outcomes referred to respiratory conditions requiring hospital admission, as lower tract infection (LRTI) or pneumonia. We used multivariable logistic...
Phage therapy (PT) shows promising potential in managing biofilm infections, which include refractory orthopedic infections. We report the case of a 13-year-old girl who developed chronic polymicrobial infection pelvic bone allograft after Ewing's sarcoma resection surgery. Chronic by Clostridium hathewayi, Proteus mirabilis and Finegoldia magna was worsened methicillin-susceptible Staphylococcus aureus exhibiting an inducible Macrolides-Lincosamides-Streptogramin B resistance phenotype...
Protection induced by acellular pertussis (aP) vaccines is partial and short-lived, especially in teenagers, calling for novel immunization strategies.We conducted an investigator-driven proof-of-concept randomized controlled trial aP-primed adolescents Geneva to assess the immunogenicity reactogenicity of a recombinant aP (r-aP) vaccine including toxin (PT) filamentous hemagglutinin (FHA) coadministered with tetanus-diphtheria toxoids (Td), compared licensed tetanus-diphtheria-aP containing...
Protection induced by acellular vaccines can be short, requiring novel immunization strategies. Objectives of this study were to evaluate safety and capacity a recombinant pertussis toxin (PTgen) -coated Viaskin® epicutaneous patch recall memory responses in healthy adults.This double-blind, placebo-controlled randomized trial (Phase I) assessed the immunogenicity PTgen administered on days 0 14 adults using patches applied directly or after epidermal laser-based skin preparation. Patch...
Maximal standard-of-care (SOC) management could not stop the life-threatening progression of a necrotizing fasciitis induced by Panton-Valentine Leukocidin-producing Methicillin-Resistant Staphylococcus aureus (MRSA) in 12-year-old boy. Multi-route phage therapy was initiated along with antibiotics against aureus, Pseudomonas aeruginosa and Stenotrophomonas maltophilia , eventually leading to full recovery no reported adverse events.
Abstract A 7-year-old child of Turkish origin presented with headache and vomiting in the context prolonged fever unknown source. At examination, oral candidiasis chronic onychomycosis were noted. Candida meningoencephalitis was diagnosed intravenous Amphotericin B liposomal given during 6 months relayed by Fluconazole after regression CNS lesions observed on MRI. complete immune evaluation performed, genetic analysis detected homozygous CARD9 mutation. deficiency have been associated...
Our study aimed to assess the severity of severe acute respiratory syndrome coronavirus 2 infection in hospitalized infants under 40 days old, across 21 Belgian hospitals between 2020 and 2022. Of 365 studied, 14.2% needed support. The median hospital stay was 3 (interquartile range, 2-4), there were no deaths. Infection similar during Omicron Alpha/Delta periods.
Les enfants faisaient partie des groupes les plus vulnérables pendant la pandémie de COVID-19. Nous avons mené cette étude afin documenter le bien-être et du personnel au sein écoles primaires francophones belges Un questionnaire 37 questions pour chaque enfant basé sur l'échelle « Revised Children's Manifest Anxiety » un 14 travailleur Hospital and Depression ont été élaborés bien-être. Des régressions logistiques effectuées évaluer relation entre autres variables explicatives. Au total,...
During the COVID-19 pandemic crisis, many measures were taken around world to limit SARS-CoV-2 transmission that disrupted people's day-to-day lives in ways. Unfortunately, most of these had detrimental consequences, such as isolation, misinformation, fear, and violence, inducing a loss wellbeing for people. One vulnerable groups consequences was children. We conducted study assess children staff French-speaking primary schools Belgium after crisis. A 37-question questionnaire based on...
Schools have been a point of attention during the pandemic, and their closure one mitigating measures taken. A better understanding dynamics transmission SARS-CoV-2 in elementary education is essential to advise decisionmakers. We conducted an uncontrolled non-interventional prospective study Belgian French-speaking schools describe role attending asymptomatic children school staff spread COVID-19 estimate others. Each participant from selected was tested for using polymerase chain reaction...
Abstract Background During the COVID-19 pandemic in 2020, closing schools was discussed as a protective measure to limit transmission of virus Belgium. There however lack evidence on role young children spread virus. We undertook study among Belgian primary order assess seroprevalence SARS-CoV-2 antibodies and its relationship with communal incidence, size socio-economic index. Method The prospective non-interventional conducted from January 14 May 18, 2021, into 11 Belgium during 6 weeks...
Purpose: During the COVID-19 pandemic, a significant number of measures were taken worldwide to limit transmission SARS-CoV-2, and in many ways, changed human life. All these had harmful consequences impacted well-being people. Children one most vulnerable groups. We conducted present study assess children’s staff’s French-speaking primary schools Belgium during pandemic. Methods: A 37-question questionnaire for each child based on Revised Children’s Manifest Anxiety Scale (RCMAS),...
Purpose: During the COVID-19 pandemic, closing schools was discussed to limit virus transmission, despite a lack of evidence on role young children in spread. We undertook study among Belgian primary assess SARS-CoV-2 antibody seroprevalence and its relationship with local incidence, school size, socioeconomic status (SES). Methods: Schools were purposively selected using three criteria: an area either low or high small large SES. 932 (/2488, 38%) 242 (/444, 55%) staff signed informed...
We report the case of a 13-year-old girl with Down's syndrome who presented cough, fever, and rapidly evolving respiratory failure leading to intensive care unit transfer during coronavirus disease 2019 (COVID-19) outbreak in Belgium. COVID-19-related acute distress (ARDS) is rare teenagers its diagnosis remains challenging as reverse transcription-polymerase chain reaction (RT-PCR)-testing sensitivity radiological criteria still have be defined that population. finally concluded severe...