A5100373452- Cancer-related molecular mechanisms research
- Influenza Virus Research Studies
- Anesthesia and Pain Management
- MicroRNA in disease regulation
- Tryptophan and brain disorders
- Circular RNAs in diseases
- Nausea and vomiting management
- Ferroptosis and cancer prognosis
- Plant Stress Responses and Tolerance
- Treatment of Major Depression
- Anesthesia and Sedative Agents
- interferon and immune responses
- RNA modifications and cancer
- Anesthesia and Neurotoxicity Research
- Virus-based gene therapy research
- Plant Molecular Biology Research
- Viral Infections and Vectors
- Intensive Care Unit Cognitive Disorders
- Virology and Viral Diseases
- Identification and Quantification in Food
- Epigenetics and DNA Methylation
- Tracheal and airway disorders
- Mental Health Research Topics
- Bacteriophages and microbial interactions
- Animal Virus Infections Studies
Wenzhou Medical University
2016-2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Zhongshan Hospital
2024
Fudan University
2019-2024
Sun Yat-sen University
2024
Wuhan University
2021-2024
Loudi Central Hospital
2024
Soochow University
2023-2024
First Affiliated Hospital of Soochow University
2023-2024
Anhui Agricultural University
2019-2024
Abstract Background Ovarian cancer (OvCa) is one of the most common malignant diseases female reproductive system in world. The majority OvCa diagnosed with metastasis abdominal cavity. Epithelial-to-mesenchymal transition (EMT) plays a key role tumor cell metastasis. However, it still unclear whether long non-coding RNA (lncRNA) implicated EMT and influences invasion OvCa. Results In this study, using bioinformatcis analysis, we constructed lncRNA-mediated competing endogenous (ceRNA)...
A novel Ebola virus (EBOV) first identified in March 2014 has infected more than 25,000 people West Africa, resulting 10,000 deaths. Preliminary analyses of genome sequences 81 EBOV collected from to June Guinea and Sierra Leone suggest that the originated an independent transmission event its natural reservoir followed by sustained human-to-human infections. It been reported variation might have effect on efficacy sequence-based detection candidate therapeutics. However, only limited viral...
Abstract Background A deeper mechanistic understanding of epithelial-to-mesenchymal transition (EMT) regulation is needed to improve current anti-metastasis strategies in ovarian cancer (OvCa). This study was designed investigate the role lncRNAs EMT during process invasion-metastasis serous OvCa for OvCa. Methods We systematically analyzes high-throughput gene expression profiles both and protein-coding genes samples with integrated epithelial (iE) subtype mesenchymal (iM) labels. Mouse...
Nasopharyngeal carcinoma (NPC) is a malignant tumor caused by an infection of the epithelial cells nasopharynx, which highly metastatic and aggressive. Due to deep anatomical site atypical early symptoms, majority NPC patients are diagnosed at terminal stages. There growing evidence that microRNAs offer options for detection, accurate diagnosis, prediction malignancy treatment response. Therefore, purpose this article was identify predict prognosis with integrating biological information...
Introduction: Remimazolam is an ultra-short-acting benzodiazepine sedative agent commonly used in general anesthesia, procedural sedation, and intensive care unit (ICU) sedation. This study aimed to explore the efficacy safety of remimazolam versus propofol for induction maintenance anesthesia preschool-age children undergoing elective surgery. Methods analysis: In this multicenter, randomized, single-blind, positive-controlled non-inferior clinical trial, one hundred ninety-two aged 3–6...
Peste des petits ruminants (PPR) is a highly contagious infectious disease of goats, sheep and small wild ruminant species with high morbidity mortality rates. The virus (PPRV) expresses hemagglutinin (H) glycoprotein on its outer envelope that crucial for viral attachment to host cells represents key antigen inducing the immune response.To determine whether H can be exploited generate an effective PPRV vaccine, replication-competent recombinant canine adenovirus type-2 (CAV-2) expressing...
We developed an electrochemical aptasensor based on cocoon-like DNA nanostructures as signal tags for highly sensitive and selective detection of <italic>Escherichia coli</italic> O157:H7.
Ketamine and its enantiomer have rapid robust effects on depressive symptom suicidal ideation. Little is known about their cognitive in adolescents. We aimed to evaluate the short-term effect of esketamine cognition adolescents with major disorder (MDD) ideation.In this randomized-controlled trial, 51 participants aged 13-18 MDD ideation received three intravenous infusions either (0.25 mg/kg) or midazolam (0.02 mg/kg). Four dimensions MATRICS Consensus Cognitive Battery (MCCB), including...
Ebola virus emerged in West Africa December 2013. The high population mobility and poor public health infrastructure this region led to the development of largest disease (EVD) outbreak date.On September 26, 2014, China dispatched a Mobile Biosafety Level-3 Laboratory (MBSL-3 Lab) well-trained diagnostic team Sierra Leone assist EVD diagnosis using quantitative real-time PCR, which allowed suspected cases less than 4 hours from time sample receiving. This laboratory was composed three...
Long non-coding RNAs (lncRNAs) play key regulatory roles in breast cancer. However, population-level differential expression analysis methods disregard the heterogeneous of lncRNAs individual patients. Therefore, we individualized lncRNA profiles for invasive carcinoma (BRCA) using method LncRNA Individualization (LncRIndiv). After evaluating robustness LncRIndiv, constructed an differentially expressed (IDElncRNA) profile BRCA and investigated subtype-specific IDElncRNAs. The cancer...
To discover candidate biomarkers for diagnosis and detection of human laryngeal carcinoma explore possible mechanisms this cancer carcinogenesis, two-dimensional strong cation-exchange/reversed-phase nano-scale liquid chromatography/mass spectrometry analysis was used to identify differentially expressed proteins between the tissue adjacent normal tissue. As a result, 281 with significant difference in expression were identified, four differential proteins, Profilin-1 (PFN1), Nucleolin...
Rationale Authentication of fish is importance in the view toxins, allergen warnings and economic fraud control. Traditional methods authentication fish, e.g. morphological, genetic proteomic analysis, are either at low throughput or high‐cost. Methods A high‐throughput matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry (MALDI TOF MS)‐based approach was developed to analyze biomaterials from skin, spectra different species were compared by chemometric differentiate...
Abstract Background The natural products, metabolites, of gut microbes are crucial effect factors on diseases. Comprehensive identification and annotation relationships among disease, can provide efficient targeted solutions towards understanding the mechanism complex disease development new markers drugs. Results We developed G ut M icrobial etabolite A ssociation with D isease (GMMAD), a manually curated database associations human diseases, microbes, metabolites microbes. Here, this...
Rabies virus (RABV) causes a fatal infection of the central nervous systems (CNS) warm-blooded animals. Once clinical symptoms develop, rabies is almost invariably fatal. The mechanism RABV pathogenesis remains poorly understood. Recent studies have shown that microRNA (miRNA) plays an important role in viral infections. Our recent findings revealed with laboratory-fixed strain can induce modulation profile mouse brains. However, no previous report has evaluated miRNA expression brains...