A5102943847- Metabolomics and Mass Spectrometry Studies
- Gut microbiota and health
- RNA modifications and cancer
- Ginseng Biological Effects and Applications
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Diabetes and associated disorders
- RNA and protein synthesis mechanisms
- Flavonoids in Medical Research
- Molecular Biology Techniques and Applications
- Animal Nutrition and Physiology
- Ga2O3 and related materials
- Microbial Metabolic Engineering and Bioproduction
- Metal-Organic Frameworks: Synthesis and Applications
- Lung Cancer Treatments and Mutations
- Multiple Myeloma Research and Treatments
- Nanopore and Nanochannel Transport Studies
- Hemoglobinopathies and Related Disorders
- Neonatal Health and Biochemistry
- Marine Sponges and Natural Products
- Electrolyte and hormonal disorders
- Healthcare and Venom Research
Zhongnan Hospital of Wuhan University
2022-2024
Wuhan University
2022-2024
Abstract Background The natural products, metabolites, of gut microbes are crucial effect factors on diseases. Comprehensive identification and annotation relationships among disease, can provide efficient targeted solutions towards understanding the mechanism complex disease development new markers drugs. Results We developed G ut M icrobial etabolite A ssociation with D isease (GMMAD), a manually curated database associations human diseases, microbes, metabolites microbes. Here, this...
N 6-Methyladenosine (m6A) is a prevalent modification in eukaryotic mRNAs and linked to various human cancers.
Laser-induced graphene (LIG) possesses characteristics of easy handling, miniaturization, and unique electrical properties. We modified the surface LIG by electropolymerizing β-cyclodextrin (β-CD), which was used to immobilize antibodies on electrode for highly sensitive detection targets.
Introduction: Genetic landscape, disease characteristics, and clinical outcomes of young adults with myeloproliferative neoplasms (MPNs) were reported. However, data on patient-reported (PROs) in MPNs rare. Methods: We conducted a multicenter, cross-sectional study to compare the PROs respondents thrombocythemia (ET), polycythemia vera (PV), myelofibrosis (MF) by age at survey, including group (18–40 years), middle-aged (41–60 elderly (>60 years). Results: Of 1,664 MPNs, 349 (21.0%)...
<title>Abstract</title> <bold>Background</bold> Depicting a global landscape of essential gene-targeting drugs would provide more opportunities for cancer therapy. Essential genes have been determined in many cell lines. However, systematic investigation on targeting still has not reported. <bold>Methods</bold> We suppose that cancer-type specific generally less toxicity than those pan-caner genes. A scoring function-based strategy was developed to identify targets and drugs. The...
The beneficial metabolites of the microbiome could be used as a tool for screening drugs that have potential therapy various human diseases. Narrowing down range metabolite candidates in specific diseases was primarily key step further validation model organisms. Herein, we proposed reasonable hypothesis existing commonly multiple (or negatively associated) bacteria might high probability being effective drug According to this hypothesis, screened associated with seven For type I diabetes,...