A5036556764- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Hematopoietic Stem Cell Transplantation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- CAR-T cell therapy research
- Lymphoma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
- Immune Cell Function and Interaction
- Kruppel-like factors research
- Immunotherapy and Immune Responses
- Chronic Lymphocytic Leukemia Research
- Extracellular vesicles in disease
- Hematological disorders and diagnostics
- Immune Response and Inflammation
- Lung Cancer Research Studies
- Histone Deacetylase Inhibitors Research
- MicroRNA in disease regulation
- Mesenchymal stem cell research
- Advanced Glycation End Products research
- T-cell and B-cell Immunology
- Eosinophilic Disorders and Syndromes
- Virus-based gene therapy research
- Retinoids in leukemia and cellular processes
Changhai Hospital
2015-2024
Second Military Medical University
2015-2024
Southern Medical University
2023
Nanfang Hospital
2023
State Council of the People's Republic of China
2019
Northwestern Medicine
2014
Cancer Genetics (United States)
2014
High mobility group box-1 (HMGB1) protein was originally characterized as a nuclear DNA-binding protein, and described to have an extracellular role when involved in cellular activation proinflammatory responses. In the present study, we found that activity of recombinant HMGB1 proteins is determined by containing endotoxin level, contains few endotoxins fails stimulate macrophages secrete cytokines. acts ligand receptor for advanced glycation end products (RAGE) works synergy with LPS...
It is generally believed that some inflammatory antigens can recognize Toll-like receptors on synovial fibroblasts (SFs) and then activate downstream signals, leading to the formation of RASFs inducing rheumatoid arthritis (RA). The objective current work was study hypothesis outer PAMP (LPS) binds inner DAMP (HMGB1) becomes a complex recognizes TLRs/RAGE SFs, thus initiating signaling cascade leads secretion cytokines chemokines, production tissue-destructive enzymes, RASFs, finally...
Hematotoxicity is the most common long-term adverse event (AE) after chimeric antigen receptor T-cell (CAR T) therapy. However, patients who receive CAR T therapy in pivotal clinical trials are subjected to restrictive selection criteria, and this means that rare but fatal toxicities underestimated. Here, we systematically analyzed T-associated hematologic AE using US Food Drug Administration Adverse Event Reporting System (FAERS) between January 2017 December 2021. Disproportionality...
Stromal fibroblasts play an important role in chronic cancer-related inflammation and the development as well progression of malignant diseases.However, difference relationship between inflammation-associated (IAFs) cancer-associated (CAFs) are poorly understood.In this study, gastric (GCAFs) their corresponding (GIAFs) were isolated from cancer (GC) with gastritis cultured vitro.These activated exhibited distinct secretion tumor-promoting behaviors vitro.Using proteomics bioinformatics...
Abstract Background Acute myeloid leukemia (AML) is a malignancy commonly seen in adults. Previous studies indicated that TRIM14 played tumorigenic role various types of cancer and miR-23b-5p was down-regulated human mesenchymal stem cell-derived exosomes (HMSC-exos) AML patients. However, their roles remains unclear. Our study aims to investigate the pathogenesis AML. Materials methods The blood specimen collected from de novo patients healthy donators. Exosomes were extracted culture...
In this work, we aimed to investigate the frequency, possible categories and clinical significance of circulating CD4 + ICOS FoxP3 T cells in patients with systemic lupus erythematosus (SLE). The frequency was analysed by flow-cytometric analysis 32 SLE patients, 10 rheumatoid arthritis healthy controls. Production IL-10 mTGF-β different T-cell populations determined intracellular cytokine staining. Plasma levels TGF-β were enzyme-linked immunosorbent assay (ELISA). significantly increased...
Autologous hematopoietic stem cell transplantation (ASCT) and chimeric antigen receptor T-cell therapy (CART) are salvage therapies that utilised for treatment of relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL). However, whether the combination ASCT CART (ASCT-CART) can improve survival R/R DLBCL remains unknown. Overall, 67 patients were included, among which 21 underwent ASCT-CART 46 therapy. The median number mononuclear cells numbers infused in groups was 4.71 × 108...
Nuclear respiratory factor-1 (Nrf1) and mitochondrial transcription factor A (TFAM) are involved in the regulation of a variety functional genes, which associated with decreased sensitivity tumor cells to chemotherapy. However, expression status Nrf1 TFAM, as well their clinical significance breast cancer, is unknown. In present study, tissues corresponding adjacent normal were collected from 336 patients TFAM was analyzed by immunohistochemistry using tissue microarray. Expression...
The presence of loss-of-heterozygosity (LOH) mutations in cancer cell genomes is commonly encountered. Moreover, the occurrences LOHs tumor suppressor genes play important roles oncogenesis. However, because causative mechanisms underlying LOH cells yet remain to be elucidated, enquiry into nature these based on a comprehensive examination characteristics multiple types cancers has become necessity. We performed next-generation sequencing inter-Alu sequences five different solid tumors and...
Acute graft-versus-host disease (aGvHD) is the most common complication of allogeneic hematopoietic stem cell transplantation (HSCT), which often accompanied by impaired reconstitution. Sinusoidal endothelial cells (SECs) constitute bone marrow (BM) vascular niche that plays an important role in supporting self-renewal capacity and maintaining stability HSC pool. Here we provide evidences a target aGvHD major histocompatibility complex (MHC)-haploidentical matched murine HSCT model. The...
Aim: Autologous hematopoietic stem cell transplantation (ASCT) is the standard-of-care curative treatment for relapsed or refractory diffuse large B-cell lymphoma (RR-DLBCL), but relapse rate usually high. Materials & methods: In this study, we treated 14 RR-DLBCL patients by combining ASCT and anti-CD19 chimeric antigen receptor T-cell therapy. Results: Eleven (78.57%) achieved complete partial remission. Median duration of progression-free survival was 14.82 months (95% CI: 0.00-31.20...
Abstract Hepatitis B surface antigen (HBsAg) and anti‐HBs antibodies (anti‐HBs) may coexist in certain chronic hepatitis (CHB) patients. This study was designed to further explore the relationship between this coexistence Virus (HBV) preS deletions. Sera of 28 patients carrying both HBsAg (Group I) those another positive but negative II) were collected from CHB Direct sequencing polymerase chain reaction products or clones applied groups determine sequences HBV S genes. Genotyping gene...
Platelet-activating factor (PAF) is an arachidonic acid metabolite that plays important role in cell proliferation, migration and neoangiogenesis, but whether it involved the progression of prostate cancer remains undiscovered.Clinical specimens were investigated with immunohistochemistry method vitro experiments referred to MTS proliferation assay, invasion experiment, quantitative real-time RT-PCR western blotting analysis ELISA assay.Platelet-activating synthetase, lyso-PAF acetyl...
Interleukin (IL)-35-secreting B (IL-35+B) cells are critical regulators in autoimmune and infectious diseases exert suppressive functions parallel with IL-10-producing (B10) cells. However, the role of IL-35+B persistent hepatitis virus (HBV) infection remains unclear. To elucidate progress chronic HBV infection, we determined frequency their relationship classical human regulatory cell (Breg) subsets, namely, CD19+CD24hiCD38hi CD19+CD24hiCD27+. Then, effect mechanism Bregs on effector T...
High expression of proviral integration site for Moloney murine leukemia virus-1 (PIM-1), a serine/threonine kinase, is associated with many cancers. The main purpose this study were to investigate that the correlation between PIM-1 mRNA levels and clinicopathologic features its clinical significance in acute myeloid (AML). qRT-PCR was performed 118 de novo AML 20 complete remission patients 15 normal individuals. All statistical analysis using Graphpad Prism5 software. We observed higher...
Summary Aquaporin 5 (AQP5) is one of the water channel proteins which participate in a wide array physiological processes and are primary determinants membrane osmotic permeability. The AQP5 gene located human chromosome 12q, same region as location major asthma susceptibility loci. In this study we try to determine whether knock-out has some effect on allergen-induced asthma. With mouse model induced by ovalbumin (OVA), found that deletion reduced characteristic features asthma, such less...