A5100379232- MicroRNA in disease regulation
- Lymphoma Diagnosis and Treatment
- Extracellular vesicles in disease
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- CAR-T cell therapy research
- Circular RNAs in diseases
- Chronic Myeloid Leukemia Treatments
- Hematopoietic Stem Cell Transplantation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Mesenchymal stem cell research
- Immune Cell Function and Interaction
- Lung Cancer Treatments and Mutations
- Viral-associated cancers and disorders
- Silicon Carbide Semiconductor Technologies
- CNS Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Childhood Cancer Survivors' Quality of Life
- RNA Interference and Gene Delivery
- Inflammasome and immune disorders
- Cutaneous lymphoproliferative disorders research
- Cancer, Hypoxia, and Metabolism
- Nuclear Structure and Function
- RNA Research and Splicing
Zhejiang Chinese Medical University
2025
Yunnan University
2025
Second Military Medical University
2015-2024
Changhai Hospital
2015-2024
Xiamen University of Technology
2024
Chengdu University of Traditional Chinese Medicine
2022
Yueyang Hospital
2022
Shanghai University of Traditional Chinese Medicine
2022
University of South China
2021
Sichuan University
2021
Malignant behavior and radioresistance, which severely limits the efficacy of radiation therapy (RT) in nasopharyngeal carcinoma (NPC), are associated with tumor progression poor prognosis. Mesenchymal stem cells (MSCs) used as a therapeutic tool variety tumors. The aim this study was to reveal effect suppressor microRNA-34c-5p (miR-34c) on NPC development well confirm that exosomes derived from MSCs overexpressing miR-34c restore sensitivity radiotherapy NPCs.Potentially active microRNAs...
Background: Enhanced infiltration of M2-polarized tumor-associated macrophages (TAMs) is linked to osteosarcoma (OS) metastasis and growth. Here, we aim explore a novel miR-221-3p shuttled by M2-TAM exosomes in the growth OS cells. Methods: THP-1 monocytes-derived M2-TAMs were induced PMA/interleukin (IL)-4/IL-13 then co-cultured with 143B Saos2 Overexpression or downregulation models conducted probe impacts exosome-derived cell proliferative ability, colony formation, invasion, migration...
Abstract Background Since angiogenesis occurs as the pathological process following myocardial infarction to alleviate ischemia, therapeutic has been proposed be a cardioprotective strategy. CD44 implicated in endothelial cell functions and its role well established for years. Although recent studies indicate close correlation between exosome, two being ischemia processes, effect underlying mechanism of regulated plasma exosome post-myocardial have not fully elucidated. Methods In this...
Abstract Exosomes are increasingly recognized as important mediators of intercellular communication in cancer biology. can be derived from cells well cellular components tumor microenvironment. After secretion, the exosomes carrying a wide range bioactive cargos ingested by local or distant recipient cells. The released act through variety mechanisms to elicit multiple biological effects and impact most if not all hallmarks cancer. Moreover, owing their excellent biocompatibility capability...
The allogeneic hematopoietic stem cell (HSC) transplantation of mesenchymal cells (MSCs) contributes to the reconstitution hematopoiesis by ameliorating acute graft‑versus‑host disease (aGVHD). However, role MSCs in graft‑versus‑leukemia remains be determined. In present study, we co‑cultured C57BL/6 mouse bone marrow (BM)‑derived with A20 murine B lymphoma, FBL3 erythroleukemia and P388 lymphocytic leukemia cells. Cell proliferation, apoptosis, cycle progression amount cytokine secretion...
Abstract Background Acute myeloid leukemia (AML) is a malignancy commonly seen in adults. Previous studies indicated that TRIM14 played tumorigenic role various types of cancer and miR-23b-5p was down-regulated human mesenchymal stem cell-derived exosomes (HMSC-exos) AML patients. However, their roles remains unclear. Our study aims to investigate the pathogenesis AML. Materials methods The blood specimen collected from de novo patients healthy donators. Exosomes were extracted culture...
Pyroptosis represents a mode of programmed necrotic cell death (PCD), mediated by members gasdermin family (GSDMs), such as GSDME. It is emerging promising approach for combating cancer. Notably, GSDME the key modulator switch between apoptosis and pyroptosis in cells. However, often downregulated many malignancies, including lung adenocarcinoma. To identify novel inducers non-small cancer (NSCLC) dissect underlying mechanism. was examined live imaging, PI/Hoechst/Annexin V staining, LDH...
Carotid artery stenosis (CAS) often goes undetected until it reaches an advanced stage, which can result in serious complications. The present study evaluated the potential of long noncoding RNA (lncRNA) LINC01088 as a biomarker for CAS. 92 CAS patients and healthy controls (Control group) were included. RT-qPCR was performed to assess relative levels miR-195-5p. Receiver operating characteristic (ROC) curve used evaluate diagnostic LINC01088. relationship between miR-195-5p identified by...
Autologous hematopoietic stem cell transplantation (ASCT) and chimeric antigen receptor T-cell therapy (CART) are salvage therapies that utilised for treatment of relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL). However, whether the combination ASCT CART (ASCT-CART) can improve survival R/R DLBCL remains unknown. Overall, 67 patients were included, among which 21 underwent ASCT-CART 46 therapy. The median number mononuclear cells numbers infused in groups was 4.71 × 108...
Aim: Autologous hematopoietic stem cell transplantation (ASCT) is the standard-of-care curative treatment for relapsed or refractory diffuse large B-cell lymphoma (RR-DLBCL), but relapse rate usually high. Materials & methods: In this study, we treated 14 RR-DLBCL patients by combining ASCT and anti-CD19 chimeric antigen receptor T-cell therapy. Results: Eleven (78.57%) achieved complete partial remission. Median duration of progression-free survival was 14.82 months (95% CI: 0.00-31.20...
Invasive mold infection (IMI) is a major cause of infection-related mortality following allogeneic hematopoietic stem cell transplantation (allo-HSCT).We retrospectively analyzed 190 allo-HSCT recipients at Changhai Hospital between the y 2000 and 2007. The survival rate was evaluated with Kaplan-Meier curves. Logistic Cox regression models were used for multivariate analyses.The 1(st) cumulative incidence IMI 12.8%, invasive aspergillosis most commonly observed (85%). Multivariate logistic...
Sphingosine-1-phosphate receptor 1 (S1PR1), the G protein-coupled of sphingosine 1-phosphate (S1P), is crucial in progression various types solid tumor through positive regulation anti‑apoptotic/pro‑survival responses by S1P‑S1PR1 signaling. However, role S1PR1 human acute myeloid leukemia (AML) remains to be fully elucidated. In present study, correlation between expression level and growth apoptosis AML cells was investigated. Using overexpression RNA interference knockdown assays, it...
This study is the first to explore genome-wide lncRNA expression and co-expression with mRNA patterns in AML ALL using microarray technology.
Microsomal epoxide hyrolase 1 (EPHX1) is a critical biotransformation enzyme and participants in both the detoxification activation of potentially genotoxic epoxides. In this study, we firstly aimed to investigate role EPHX1 chemoresistance acute myeloid leukemic cells aclarubicin (ACM) mitoxantrone (MIT). mRNA expression prognosis were measured leukemia (AML) patients, function cell viability apoptosis induced by ACM MIT was also measured. Our results found that obviously associated with...
Background: GC-binding factor 2 (GCF2) is a transcriptional regulator that represses activity of the epidermal growth receptor (EGFR) by binding to specific GC-rich sequence in EGFR gene promoter. In addition this function, GCF2 has also been identified as tumor-associated antigen and regarded potentially valuable serum biomarker for early human hepatocellular carcinoma (HCC) diagnosis. high expressed most HCC tissues cell lines including HepG2. This study focused on influence proliferation...
Abstract Notch exerts important functions in cell proliferation, survival, and differentiation, which plays a critical role tumor development when aberrantly activated. Mastermind‐like protein 1 (MAML1) has been functioning as crucial coactivators of receptors is required for stable formation transcriptional complexes. However, the mechanism whereby MAML1 induces T‐cell acute lymphoblastic leukemia (T‐ALL) tumorigenesis largely unknown. The CCK‐8 flow cytometry assay were performed to...
Abstract Background To explore the effects of monitoring measurable residual disease and post‐remission treatment selection on clinical outcomes B‐cell acute lymphoblastic leukemia (B‐ALL) in adults. Methods Between September 2010 January 2022, adult patients with B‐ALL who received combination chemotherapy, or without allogeneic hematopoietic stem cell transplantation (allo‐HSCT), were included retrospective study, which was approved by Ethics Committee observation Declaration Helsinki...
Objective: To compare the difference of efficacy between traditional Hyper-CVAD/MA regimen and adolescents inspired chemotherapy regimen, CH ALL-01, in treatment adult Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph(+) ALL) . Methods: In this study we retrospectively analyzed 158 Ph(+) ALL patients receiving (n=63) or CHALL-01 (n=95) our center Changzheng hospital from January 2007 to December 2017, excluding with chronic myeloid blast crisis. Tyrosine kinase inhibitor...