A5100449975- Bone Tissue Engineering Materials
- Orthopaedic implants and arthroplasty
- RNA Research and Splicing
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Advanced Glycation End Products research
- RNA modifications and cancer
- Physics of Superconductivity and Magnetism
- Immune Response and Inflammation
- Advanced Condensed Matter Physics
- Magnesium Alloys: Properties and Applications
- Topological Materials and Phenomena
- Quantum, superfluid, helium dynamics
- Heat shock proteins research
- ATP Synthase and ATPases Research
- biodegradable polymer synthesis and properties
- Molecular Biology Techniques and Applications
- Inflammasome and immune disorders
- Graphene and Nanomaterials Applications
- 2D Materials and Applications
- Dental Implant Techniques and Outcomes
- NF-κB Signaling Pathways
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Extracellular vesicles in disease
Beijing Institute of Technology
2023-2024
Changhai Hospital
2009-2022
Second Military Medical University
2011-2022
Affiliated Hospital of Nantong University
2015
Nantong University
2015
High mobility group box-1 (HMGB1) protein was originally characterized as a nuclear DNA-binding protein, and described to have an extracellular role when involved in cellular activation proinflammatory responses. In the present study, we found that activity of recombinant HMGB1 proteins is determined by containing endotoxin level, contains few endotoxins fails stimulate macrophages secrete cytokines. acts ligand receptor for advanced glycation end products (RAGE) works synergy with LPS...
Deregulated microRNAs and their roles in cancer development have attracted much attention. Although miR-133a has been shown to be important osteogenesis, its osteosarcoma carcinogenesis progression remain unknown. Hence, we focused on the expression mechanisms of this study. We found that was downregulated cell lines primary human tissues, decrease significantly correlated with tumor prognosis patients. Functional studies revealed restoration could reduce proliferation, promote apoptosis,...
Synovial fibroblasts (SF) play a central role in the inflammatory and destructive process rheumatoid arthritis (RA). High-mobility group box chromosomal protein 1 (HMGB1) or lipopolysaccharide (LPS) alone failed to induce significant changes proliferation of cultured SF from RA patients, but premixed HMGB1 with LPS (HMGB1-LPS) significantly facilitated proliferation. IL-6, MMP-3, MMP-13 production greatly enhanced LPS-induced expression at both mRNA levels. HMGB1-LPS synergistically...
Neural stem cells (NSCs) have been defined as neural with the potential to self-renew and eventually generate all cell types of nervous system. NSCs serve an ideal type for system repair. In present study, miR-146 overexpression predicted target (notch 1) were used study proliferation differentiation mouse NSCs. shRNA demonstrate function Notch 1 in luciferase reporter assay was assess confirm binding sequence 3′-UTR between miR-146. Results showed that knockdown notch inhibited under...
Abstract Bone defects remains a challenge for surgeons. graft scaffold can fill the defect and enhance bone regeneration. Demineralized matrix (DBM) is an allogeneic substitute, which only be used as filling material rather than structural graft. Coating of scaffolds with nanoscale DBM may osteoinductivity or osteoconductivity. Herein lyophilization method presented to coat nano‐DBM on surface porous polycaprolactone (PCL)/β‐tricalcium phosphate (β‐TCP) fabricated by 3D printing technology....
Abstract Objectives Osteosarcoma is the most commonly diagnosed primary malignancy of bone and its overall survival rate still very low. The molecular mechanisms underlying progression osteosarcoma have not been clearly illuminated. Heat shock transcription factor 1 ( HSF 1) a key regulator heat response also plays important roles in many cancers, but function remains unexplored. Materials methods In this study, proliferation cells was determined by Cell Counting Kit‐8 assays colony...
MicroRNAs play important roles in the development of cancers. Although miR-92b has been reported to promote tumorigenesis some cancers, its role osteosarcoma remains unknown. In present study, we focused on expression, function and mechanisms development. The miRNA was up-regulated cell lines tissues; up-regulation correlated with poor prognosis osteosarcoma. Overexpression promoted proliferation, migration invasion, which abrogated by inhibition. Reversion-inducing, cysteine-rich protein...
Abstract Magnesium phosphate (MP) was fabricated using a chemical precipitation method, and the biological performances of MP sintered at different temperatures as biomedical material investigated. The results indicated that densification crystallinity increased sintering temperature increased. As increased, degradability in PBS decreased, mineralization ability SBF significantly In addition, 800 °C (MP8) possessed lowest highest ability. Moreover, positive response MG63 cells to MP8...
Macro-mesoporous scaffolds based on wheat gliadin (WG)/mesoporous magnesium calcium silicate (m-MCS) biocomposites (WMC) were developed for bone tissue regeneration. The increasing amount of m-MCS significantly improved the mesoporosity and water absorption WMC while slightly decreased their compressive strength. With increase content, degradability was obviously enhanced, decrease pH value could be slow down after soaking in Tris-HCl solution different time. Moreover, apatite mineralization...
Abstract: A bioactive composite of nano calcium-deficient apatite (n-CDAP) with an atom molar ratio calcium to phosphate (Ca/P) 1.50 and poly(ε-caprolactone)–poly(ethylene glycol)–poly(ε-caprolactone) (PCL–PEG–PCL) was synthesized, a scaffold fabricated. The scaffolds 40 wt% n-CDAP contained well interconnected macropores around 400 µm, exhibited porosity 75%. weight-loss the n-CDAP/PCL–PEG–PCL significantly greater than hydroxyapatite (n-HA, Ca/P = 1.67)/PCL–PEG–PCL during soaking into...
As many kagome metals, the topological superconductor ${\mathrm{AV}}_{3}{\mathrm{Sb}}_{5}$ with (A = K,Rb,Cs) hosts a charge density wave. A related chiral flux phase that breaks time-reversal symmetry has been further theoretically predicted in these materials. The is associated loop currents produce ordered orbital magnetic moments, which would occur at momentum points, $\mathbf{M}$, characterizing charge-density wave state. Polarized neutron-diffraction experiments have performed on an...
Our study aimed to investigate the relationship between MALAT-1 (metastasis-associated lung adenocarcinoma transcript 1) expression and chemotherapy drug resistance in osteosarcoma.The U-2OS osteosarcoma cell line was selected for experiment. The cells were treated with methotrexate, doxorubicin, cisplatin, ifosfamide, respectively. RT-PCR applied detect cells. doxorubicin-resistant constructed. divided into doxorubicin-sensitivity group (DS/shCtrl), doxorubicin-resistance (DR/shCtrl)...
Abstract Background This study aimed to investigate the correlation of long intergenic non‐coding RNA 511 (LINC00511) with clinicopathological characteristics and overall survival (OS) in osteosarcoma patients explore its function vitro vivo. Methods Tumor tissues adjacent from 45 were acquired, LINC00511 expression was detected. In vitro, detected cell lines osteoblast line. overexpression‐treated (OE‐LINC00511) nonsense (OE‐control) MG‐63 Saos‐2 cells cultured, followed by assessment...
Ever since the discovery of charge density wave (CDW) transition in kagome metal CsV$_3$Sb$_5$, nature its symmetry breaking is under intense debate. While evidence suggests that rotational already broken at CDW temperature ($T_{\rm CDW}$), an additional electronic nematic instability well below $T_{\rm CDW}$ has been reported based on diverging elastoresistivity coefficient anisotropic channel ($m_{E_{2g}}$). Verifying existence a not only critical for establishing correct description order...
Nanoporous calcium silicate (n‐CS) with high surface area was synthesized using the mixed surfactants of EO 20 PO 70 (polyethylene oxide) (polypropylene , P123) and hexadecyltrimethyl ammonium bromide (CTAB) as templates, its composite poly(lactic acid‐co‐glycolic acid) (PLGA) were fabricated. The results showed that n‐CS/PLGA (n‐CPC) wt% n‐CS could induce a dense continuous layer apatite on after soaking in simulated body fluid (SBF) for 1 week, suggesting excellent vitro bioactivity. n‐CPC...
TiSe$_2$ is a typical transition-metal dichalcogenide known for its charge-density wave order. In this study, we report the observation of an unusual anisotropic negative magnetoresistance in exfoliated nanoflakes at low temperatures. Unlike reported most other dichalcogenides, our results cannot be explained by either conventional two-dimensional weak localization effect or Kondo effect. A comprehensive analysis data suggests that observed flakes likely caused three-dimensional Our findings...