A5025512426- RNA modifications and cancer
- MicroRNA in disease regulation
- Obesity, Physical Activity, Diet
- Physical Activity and Health
- Ferroptosis and cancer prognosis
- Long-Term Effects of COVID-19
- Peptidase Inhibition and Analysis
- SARS-CoV-2 and COVID-19 Research
- Advanced Wireless Network Optimization
- RNA Research and Splicing
- Circular RNAs in diseases
- Signaling Pathways in Disease
- RNA and protein synthesis mechanisms
- Single-cell and spatial transcriptomics
- Nutritional Studies and Diet
- Virus-based gene therapy research
- Advanced MIMO Systems Optimization
- GDF15 and Related Biomarkers
- Cancer-related gene regulation
- Health and Lifestyle Studies
- COVID-19 Clinical Research Studies
- CAR-T cell therapy research
- Wireless Networks and Protocols
- Trace Elements in Health
Chinese People's Liberation Army
2025
People's Liberation Army 401 Hospital
2024-2025
Changhai Hospital
2021-2024
Second Military Medical University
2021-2024
Hematotoxicity is the most common long-term adverse event (AE) after chimeric antigen receptor T-cell (CAR T) therapy. However, patients who receive CAR T therapy in pivotal clinical trials are subjected to restrictive selection criteria, and this means that rare but fatal toxicities underestimated. Here, we systematically analyzed T-associated hematologic AE using US Food Drug Administration Adverse Event Reporting System (FAERS) between January 2017 December 2021. Disproportionality...
Imbalanced dietary patterns, sedentary behavior, and other unhealthy lifestyle behaviors are among the potentially modifiable risk factors most consistently linked to all-cause cardiovascular disease (CVD) mortality. This study aimed investigate joint association of antioxidant intakes from diet supplements behavior with CVD retrospective cohort included 16,019 adults National Health Nutrition Examination Survey (NHANES) 2007–2014. All-cause mortality was ascertained by linkage Death Index...
Background In 2023, the American Heart Association defined concept of cardiovascular–kidney–metabolic (CKM) syndrome as a health disorder ascribed to connections among obesity, diabetes, chronic kidney disease, and cardiovascular disease. We aim examine association between overall sleep quality advanced CKM syndrome. Methods This cross‐sectional study used data on US adults from National Health Nutrition Examination Survey 2015 2020. Overall was evaluated by summarizing 5 behaviors:...
Abstract Background N 7 -methylguanosine (m G) modification has been reported to regulate RNA expression in multiple pathophysiological processes. However, little is known about its role and association with immune microenvironment heart failure (HF). Results One hundred twenty-four HF patients 135 nonfailing donors (NFDs) from six microarray datasets the gene omnibus (GEO) database were included evaluate profiles of m G regulators. revealed that 14 regulators differentially expressed...
Heart failure (HF) is a major public health issue with high mortality and morbidity. This study aimed to find potential diagnostic markers for HF by the combination of bioinformatics analysis machine learning, as well analyze role immune infiltration in pathological process HF. The gene expression profiles 124 patients 135 nonfailing donors (NFDs) were obtained from six datasets NCBI Gene Expression Omnibus (GEO) database. We applied robust rank aggregation (RRA) weighted co-expression...
Heart failure (HF) represents the advanced stage of several cardiovascular disorders. This study aimed to build an alternative splicing regulatory network and identify potential factors involved in HF utilizing RNA-seq data machine learning algorithms. We performed bioinformatics analysis on datasets containing samples from patients normal individuals obtain gene expression matrices differently regulated events HF. By calculating percent spliced-in (PSI) value, we identified 4055 abnormal...
Background Heart failure (HF) is the end stage of various cardiovascular diseases with a high mortality rate. Novel diagnostic and therapeutic biomarkers for HF are urgently required. Our research aims to identify HF-related hub genes regulatory networks using bioinformatics validation assays. Methods Using four RNA-seq datasets in Gene Expression Omnibus (GEO) database, we screened differentially expressed (DEGs) Removal Unwanted Variation from data (RUVSeq) robust rank aggregation (RRA)...
Backgrounds Cuprotosis is a newly discovered programmed cell death by modulating tricarboxylic acid cycle. Emerging evidence showed that cuprotosis-related genes (CRGs) are implicated in the occurrence and progression of multiple diseases. However, mechanism cuprotosis heart failure (HF) has not been investigated yet. Methods The HF microarray datasets GSE16499, GSE26887, GSE42955, GSE57338, GSE76701, GSE79962 were downloaded from Gene Expression Omnibus (GEO) database to identify...
In this paper, we consider the performances in terms of system throughput and response time various channel-aware scheduling algorithms for both MPEG streams non-MPEG flows a high-data-rate (HDR) wireless personal area network (WPAN). The under investigation are shortest remaining processing rule, exponential modified largest weighted delay first maximum rate proportionally fair rule. Decodability issues taken care by means frame-decodability aware technique burst transfer eligibility...
近年来转录组测序技术实现了从低通量到高通量的快速发展。但传统的转录组测序技术局限于群体细胞基因表达平均水平，忽视了细胞间的异质性，而单细胞转录组测序可在单个细胞水平得到基因表达图谱，在分析细胞异质性、寻找心血管疾病新的诊断和治疗靶点以及促进心脏再生中发挥重要作用。该文综述了单细胞转录组测序在心血管疾病领域应用的研究进展。.