A5021186274- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Immunotherapy and Immune Responses
- Dermatology and Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Extracellular vesicles in disease
- Advancements in Transdermal Drug Delivery
- Graphene and Nanomaterials Applications
- Advanced biosensing and bioanalysis techniques
- Virus-based gene therapy research
- Antimicrobial Peptides and Activities
- Adenosine and Purinergic Signaling
- MicroRNA in disease regulation
- Surfactants and Colloidal Systems
- Immune Cell Function and Interaction
- Computational Drug Discovery Methods
- Transgenic Plants and Applications
- Metastasis and carcinoma case studies
- Phytochemistry and Biological Activities
- Aquaculture disease management and microbiota
- Bioactive natural compounds
- Wound Healing and Treatments
Shanghai Skin Disease Hospital
2020-2025
Tongji University
2020-2025
Shanghai Innovative Research Center of Traditional Chinese Medicine
2021-2024
Second Military Medical University
2010-2023
Changhai Hospital
2014-2023
Eastern Hepatobiliary Surgery Hospital
2021
ORCID
2020
Psoriasis is a chronic autoimmune inflammatory disease characterized by erroneous metabolism of keratinocytes. The development psoriasis closely related to abnormal activation and disorders the immune system. Dysregulated skin protective mechanisms can activate pathways within epithelial microenvironment (EIME), leading autoimmune-related diseases. In this review, we initially emphasized pathogenesis psoriasis, paying particular attention interactions between cells production cytokines in...
Purpose: Photodynamic therapy (PDT) has been an attractive strategy for skin tumor treatment. However, the hypoxic microenvironment of solid tumors and further O 2 consumption during PDT would diminish its therapeutic effect. Herein, we developed a using combination hypoxia-activated bioreductive drug tirapazamine (TPZ). Methods: TPZ was linked to DSPE-PEG-NHS forming DSPE-PEG-TPZ solve leakage water-soluble serve as antitumor agent monomer molecule micellar. Chlorin e6 (Ce6) loaded in...
Macrophages with tumor-tropic migratory properties can serve as a cellular carrier to enhance the efficacy of anti neoplastic agents. However, limited drug loading (DL) and insufficient release at tumor site remain main obstacles in developing macrophage-based delivery systems. In this study, we constructed biomimetic system (BDS) by doxorubicin (DOX)-loaded reduced graphene oxide (rGO) into mouse macrophage-like cell line (RAW264.7), hoping that newly BDS could perfectly combine ability...
Cancer immunotherapy can enhance the antitumor effect of drugs through a combinatorial approach in synergistic manner. However, effective targeted delivery various remains challenge. We generated peptide assembling tumor-targeted nanodelivery system based on breast cancer homing and penetrating for codelivery programmed cell death ligand 1 (PD-L1) small interfering RNA (siRNA) (siPD-L1) an indoleamine 2,3-dioxygenase inhibitor as dual blockade immune checkpoint. The vector is capable...
Background Fufang Honghua Buji (FHB) granules, have proven efficacy against vitiligo in long-term clinical practice. However, its major active chemical components and molecular mechanisms of action remain unknown. The purpose this study was to confirm the mechanism FHB’s therapeutic effect on utilizing network pharmacology, docking, dynamics simulation prediction, as well experimental verification. Methods Traditional Chinese Medicine Systems Pharmacology (TCMSP) HERB databases were used...
Abstract Background Topical anticancer drugs offer a potential therapeutic modality with high compliance for treating cutaneous squamous cell carcinoma (cSCC). However, the existing topical treatments cSCC are associated limited penetrating ability to achieve desired outcome. Therefore, there remains an urgent requirement develop efficient activity suitable and overcome skin physiological barrier improve efficiency of drug delivery tumor. Results We introduced lycorine (LR) into treatment...
Inflammatory skin diseases are a group of caused by the disruption tissue due to immune system disorders. Histone modification plays pivotal role in pathogenesis and treatment chronic inflammatory diseases, encompassing wide range conditions, including psoriasis, atopic dermatitis, lupus, systemic sclerosis, contact lichen planus, alopecia areata. Analyzing histone as significant epigenetic regulatory approach holds great promise for advancing our understanding managing these complex...
Atopic dermatitis (AD) is a prevalent chronic inflammatory skin disease. The Janus kinase (JAK) has been identified as target in AD, it regulates specific genes and adaptive immune responses. However, the efficacy of topically applied JAK inhibitors AD limited due to unique structure skin. We synthesized JAK1/JAK2 degraders (JAPT) based on protein degradation targeting chimeras (PROTACs) prepared them into topical preparations. JAPT exploited E3 ligase mediate ubiquitination JAK1/JAK2,...
RNA-based delivery system for cancer therapy remains a challenge. In this study, stearyl-peptide (SHR) was synthesized using arginine, histidine, cysteine, and stearyl moieties. Further, the stearyl-peptides were cross-linked by disulfide bonds to obtain polypeptides (SHRss) with different molecular weight (SHRss1, SHRss2, SHRss3, SHRss4). The SHRss could effectively condense small interfering RNA (siRNA) into polyplexes hydrodynamic size of 100–300 nm zeta potential 20–40 mV. Flow cytometry...
Purpose: The clinical management of patients with castration-resistant prostate cancer (CRPC) is difficult. However, novel treatment methods are gradually being introduced. Considering the adverse effects traditional treatments, recent studies have investigated gene therapy as a method to combat CRPC; but, application long non-coding (lnc) RNA in remains scarce, despite their promise. Therefore, it imperative develop system that can efficiently deliver lncRNA for CRPC. Here, we efficacy...
Combination immunotherapy is a promising strategy to remove the inhibitory effect of tumor microenvironment on immune effector cells, improving efficacy checkpoint inhibitor treatment in bladder cancer. However, it challenging deliver multiple drugs tissue effectively and simultaneously ensure optimal therapeutic effects. Macrophage-derived exosome-mimetic nanovesicles (EMVs) were designed validated as nanoplatform for coloading delivery CD73 (AB680) monoclonal antibody programmed cell death...
Hematotoxicity is the most common long-term adverse event (AE) after chimeric antigen receptor T-cell (CAR T) therapy. However, patients who receive CAR T therapy in pivotal clinical trials are subjected to restrictive selection criteria, and this means that rare but fatal toxicities underestimated. Here, we systematically analyzed T-associated hematologic AE using US Food Drug Administration Adverse Event Reporting System (FAERS) between January 2017 December 2021. Disproportionality...
Doxorubicin (Dox) has been recommended in clinical guidelines for the standard-of-care treatment of breast cancer. However, Dox therapy faces challenges such as hypoxia, acidosis, H2O2-rich conditions and condensed extracellular matrix TME well low targeted ability.We developed a nanosystem H-MnO2-Dox-Col NPs based on mesoporous manganese dioxide (H-MnO2) which was loaded core collagenase (Col) wrapped surface. Further were covered by fusion membrane (MP) inflammation-targeted RAW264.7 cell...
Tumor immunotherapy is a promising approach for addressing the limitations of conventional tumor treatments, such as chemotherapy and radiotherapy, which often have side effects fail to prevent recurrence metastasis. However, effectiveness sustainability immune activation in remain challenging. immunogenic cell death, characterized by release substances, damage associated molecular patterns (DAMPs), antigens, from dying cells (DTCs), offers potential solution. By enhancing immunogenicity...
Chronic skin wounds are a leading cause of hospital admissions and reduced life expectancy among older people individuals with diabetes. Delayed wound healing is often attributed to series cellular abnormalities. Matrine, well-studied component found in