A5101943422- Mechanical Behavior of Composites
- Optical measurement and interference techniques
- Composite Structure Analysis and Optimization
- Corneal surgery and disorders
- Corneal Surgery and Treatments
- Computational Drug Discovery Methods
- Structural Analysis of Composite Materials
- Structural Behavior of Reinforced Concrete
- Cancer, Hypoxia, and Metabolism
- Adrenal and Paraganglionic Tumors
- Natural Fiber Reinforced Composites
- Acoustic Wave Phenomena Research
- Ocular Surface and Contact Lens
- Cancer, Lipids, and Metabolism
- Estrogen and related hormone effects
- Structural Load-Bearing Analysis
- Advanced Surface Polishing Techniques
- Advanced materials and composites
- Glaucoma and retinal disorders
- Image Processing Techniques and Applications
- Glioma Diagnosis and Treatment
- Advanced Measurement and Detection Methods
- Microbial Natural Products and Biosynthesis
- Hormonal Regulation and Hypertension
- Cancer Mechanisms and Therapy
National Center for Advancing Translational Sciences
2013-2025
National Institutes of Health
2013-2025
Tianjin University
2012-2024
Shanghai Skin Disease Hospital
2024
Tongji University
2024
Shanghai Innovative Research Center of Traditional Chinese Medicine
2024
Huzhou Central Hospital
2024
Wuhan Textile University
2012-2024
Chang Gung University
2023
Chang Gung Memorial Hospital
2023
Ferroptosis is a recently discovered form of programmed cell death, but its regulatory mechanisms remain poorly understood. Here, we show that the RNA-binding protein ZFP36/TTP (ZFP36 ring finger protein) plays crucial role in regulating ferroptosis hepatic stellate cells (HSCs). Upon exposure to ferroptosis-inducing compounds, ubiquitin ligase FBXW7/CDC4 (F-box and WD repeat domain containing 7) decreased ZFP36 expression by recognizing SFSGLPS motif. FBXW7 plasmid contributed classical...
Purpose: Photodynamic therapy (PDT) has been an attractive strategy for skin tumor treatment. However, the hypoxic microenvironment of solid tumors and further O 2 consumption during PDT would diminish its therapeutic effect. Herein, we developed a using combination hypoxia-activated bioreductive drug tirapazamine (TPZ). Methods: TPZ was linked to DSPE-PEG-NHS forming DSPE-PEG-TPZ solve leakage water-soluble serve as antitumor agent monomer molecule micellar. Chlorin e6 (Ce6) loaded in...
Abstract Aims Diabetic cardiomyopathy, characterized by myocardial structural and functional changes, is a specific cardiomyopathy develops in patients with diabetes mellitus. The present study was to investigate the role of kinin B2 receptor-Akt-glycogen synthase kinase (GSK)-3β signalling pathway mediating protective effects tanshinone IIA (TSN) on diabetic cardiomyopathy. Methods results Streptozocin (STZ) induced rats (n = 60) were randomized receive TSN, TSN plus HOE140 (a receptor...
This study was designed to investigate whether Resveratrol (Res) could be a prophylactic factor in the prevention of I/R injury and shed light on its underlying mechanism. Primary culture neonatal rat cardiomyocytes were randomly distributed into three groups: normal group (cultured conditions), subjected 2 h simulated ischemia followed by 4 reperfusion), Res+I/R (100 µmol/L Res administered before reperfusion). To test extent cardiomyocyte injury, several indices detected including cell...
Abstract Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer. Most MCCs contain polyomavirus (virus-positive MCC; VP-MCC), and the remaining are virus-negative (VN-MCC). Immune checkpoint inhibitors first-line treatment for metastatic MCC, but durable responses achieved in less than 50% of patients. To identify new treatments, we screen ~4,000 compounds their ability to reduce MCC viability demonstrate that VP-MCC VN-MCC exhibit distinct response profiles. Aurora kinase selectively...
The caspase proteins are essential for the regulation of normal B cell development and apoptosis. We investigated five single nucleotide polymorphisms in four key genes, CASP3 [Ex8-280C>A (rs6948) Ex8+567T>C (rs1049216)], CASP8 Ex14-271A>T (rs13113), CASP9 Ex5+32G>A (rs1052576) CASP10 Ex3-171A>G (rs3900115) to determine whether they alter risk non-Hodgkin lymphoma (NHL) a population-based case–control study women Connecticut (461 cases 535 controls). Variants were significantly associated...
Context: Salvia miltiorrhiza Bunge is a traditional Asian medicine used to treat cerebral and cardiac ischemia. However, the effects of active compounds S. on liver damage are unclear.Objective: In this study, we tested acute injury crude extracts from roots as well neotanshinone B, dehydromiltirone, tanshinol A, tanshinone I, dihydrotanshinono cryptanshinono, II salvianolie acid B purified extracts.Materials methods: Various or ethanol extract (50, 100, 200 mg/kg, p.o.) were administered...
Epidemiological studies suggest that trichloroethylene (TCE) exposure may be associated with renal cancer. The biological mechanisms involved are not exactly known although nephrotoxicity is believed to play a role. Studies on TCE among humans, however, have been largely inconsistent. We studied kidney toxicity in Chinese factory workers exposed using novel sensitive markers. Eighty healthy and 45 comparable unexposed controls were included the present analyses. Personal measurements taken...
Purpose . To investigate the anisotropic characteristics of normal human corneal stroma using fresh tissue. Methods Sixty-four specimens extracted from stromal lenticules were included in this study. The cut temporal-nasal (horizontal) or superior-inferior (vertical) direction. Strip subjected to uniaxial tensile testing. properties measured and compared two directions. Results low-strain tangent modulus was statistically significantly greater vertical direction than horizontal (1.32 ± 0.50...
Background: Endothelial-to-mesenchymal transition (EndMT) is an important source of myofibroblasts that directly affects cardiac function in diabetic cardiomyopathy (DCM) via unknown underlying mechanism. Sirt6 a member the Sirtuin family NAD(+)-dependent enzymes plays role glucose and fatty acid metabolism. In this study, we investigated whether participates EndMT during development T2DM possible regulatory mechanisms. Methods: Endothelium-specific knockout (Sirt6-KO EC ) mice (C57BL/6...
The load forecasting of power system planning, electricity, scheduling and other departments the foundation work, is influenced by grid for life reliability an important factor, In this paper a over past five years total data, data analysis pretreatment, By using ARIMA model grey GM (1, 1) province's electricity divided in 3 days, 10 two cases to make short-term prediction, compares advantages disadvantages methods accuracy.