A5100388442- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- EEG and Brain-Computer Interfaces
- Pharmacological Effects and Toxicity Studies
- Functional Brain Connectivity Studies
- Neonatal and fetal brain pathology
- Advanced MRI Techniques and Applications
- Retinal Imaging and Analysis
- Advanced Neuroimaging Techniques and Applications
- Fetal and Pediatric Neurological Disorders
- Membrane Separation Technologies
- Metabolism and Genetic Disorders
- Retinal Diseases and Treatments
- Tryptophan and brain disorders
- Diet and metabolism studies
- Nanopore and Nanochannel Transport Studies
- Neurological disorders and treatments
- Maternal and fetal healthcare
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Obstructive Sleep Apnea Research
- Bipolar Disorder and Treatment
- Membrane-based Ion Separation Techniques
- Ectopic Pregnancy Diagnosis and Management
- Glioma Diagnosis and Treatment
Second Affiliated Hospital of Zhejiang University
2016-2025
Cleveland Clinic
2018-2025
Capital Institute of Pediatrics
2022-2024
Zhengzhou Children's Hospital
2024
Zhengzhou University
2024
Shandong Jianzhu University
2022-2024
Duke Kunshan University
2023-2024
Oxford Brookes University
2024
University of Bath
2024
Harbin University of Commerce
2024
Abstract A role for endocannabinoid signaling in neuronal morphogenesis as the brain develops has recently been suggested. Here we used developing somatosensory circuit a model system to examine of neural formation. We first show that deficiency cannabinoid receptor type 1 (CB R), but not G‐protein‐coupled 55 (GPR55), leads aberrant fasciculation and pathfinding both corticothalamic thalamocortical axons despite normal target recognition. Next, localized CB R expression projections found...
Drug-resistant focal epilepsy is often caused by cortical dysplasias (FCDs). The distribution of these lesions across the cerebral cortex and impact lesion location on clinical presentation surgical outcome are largely unknown. We created a neuroimaging cohort patients with individually mapped FCDs to determine factors associated predictors postsurgical outcome.
Abstract One outstanding challenge for machine learning in diagnostic biomedical imaging is algorithm interpretability. A key application the identification of subtle epileptogenic focal cortical dysplasias (FCDs) from structural MRI. FCDs are difficult to visualize on MRI but often amenable surgical resection. We aimed develop an open-source, interpretable, surface-based machine-learning automatically identify heterogeneous data epilepsy surgery centres worldwide. The Multi-centre Epilepsy...
Background and purpose: Surgical management of patients with cingulate epilepsy (CE) is highly challenging, especially when the MRI nonlesional. We aimed to use a voxel-based post-processing technique, implemented in morphometric analysis program (MAP), facilitate detection subtle epileptogenic lesions CE, thereby improving surgical evaluation CE nonlesional by visual inspection. Methods: Included this retrospective study were 9 (6 negative 3 subtly lesional MRI) who underwent surgery became...
ABSTRACT Previous studies suggested that lower vitamin D might be a risk factor for autism spectrum disorders (ASDs). The aim of this study was to estimate the prevalence ASDs in 3-year-old Chinese children and examine association between neonatal status ASDs. We conducted live births who had taken part expanded newborn screening (NBS), with outpatient follow-up when 3-year old. were confirmed by Autism Diagnostic Interview-Revised Statistical Manual Mental Disorders (DSM)-5 criteria....
Neonatal hypoxic-ischemic encephalopathy (HIE) refers to nervous system damage caused by perinatal hypoxia, which is the major cause of long-term neuro-developmental disorders in surviving infants. However, mechanisms still require further investigation. In this study, we found that butanoate metabolism pathway exhibited significantly decreased and short chain fatty acid (SCFAs)-producing bacteria, especially butyrate-producing were fecal neonatal brain (HIBD) rats. Surprisingly, Sodium...
Importance A leading cause of surgically remediable, drug-resistant focal epilepsy is cortical dysplasia (FCD). FCD challenging to visualize and often considered magnetic resonance imaging (MRI) negative. Existing automated methods for detection are limited by high numbers false-positive predictions, hampering their clinical utility. Objective To evaluate the efficacy interpretability graph neural networks in automatically detecting lesions on MRI scans. Design, Setting, Participants In this...
Abstract Hypoxia–ischaemia ( HI ) remains a major cause of foetal brain damage presented scarcity effective therapeutic approaches. Dexmedetomidine DEX and micro RNA ‐140‐5p (miR‐140‐5p) have been highlighted due to its potentially significant role in the treatment cerebral ischaemia. This study was investigate by which miR‐140‐5p provides protection using treat hypoxic–ischaemic HIBD neonatal rats via Wnt/β‐catenin signalling pathway. The rat models were established allocated into various...
Several studies have shown the positive clinical effect of brain computer interface (BCI) training for stroke rehabilitation. This study investigated efficacy sensorimotor rhythm (SMR)-based BCI with audio-cue, motor observation and multisensory feedback post-stroke Furthermore, we discussed interaction between intensity duration in training. Twenty-four patients severe upper limb (UL) deficits were randomly assigned to two groups: 2-week SMR-BCI combined conventional treatment (BCI Group,...
Epilepsy is a chronic disorder characterized by recurrent seizures and has significant psychological social consequence for everyday living. affects various aspects of ones' life. The present study aimed to investigate the influence marital status on quality life adult Chinese patients with epilepsy.This surveyed 805 adults who have been clinically diagnosed epilepsy longer than 1 year in 11 hospitals Beijing. In this survey, 532 (66.1%) participants were married. All them completed case...
To understand the prevalence, awareness, and risk factors for diabetic retinopathy (DR) among Chinese with known type-2 diabetes mellitus (T2DM) in eastern China communities.A community-based survey including 913 patients T2DM was conducted Suzhou, China. Diabetes defined as hemoglobin A1c (hbA1c) ≥6.5%, use of medication or a physician diagnosis diabetes. Retinal photographs were graded presence DR using Airlie House classification system. Binary logistic regression models established to...
Summary Objective The epileptogenic network underlying secondarily generalized tonic–clonic seizures ( sGTCS ) in mesial temporal lobe epilepsy mTLE is not well understood. Here, we investigated alterations the probabilistic hippocampal‐thalamic pathway pHTP using diffusion tensor imaging and resting‐state functional magnetic resonance a cohort of TLE patients with hippocampal sclerosis (HS). Methods We consecutively recruited 51 unilateral ‐ HS (26 25 without 22 healthy controls....