Katy Vecchiato
A5029866842- Functional Brain Connectivity Studies
- Neonatal and fetal brain pathology
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Epilepsy research and treatment
- Fetal and Pediatric Neurological Disorders
- Infant Development and Preterm Care
- EEG and Brain-Computer Interfaces
- MRI in cancer diagnosis
- Neonatal Respiratory Health Research
- Atomic and Subatomic Physics Research
- Neural dynamics and brain function
- Iron Metabolism and Disorders
- Preterm Birth and Chorioamnionitis
- Adrenal Hormones and Disorders
- Glioma Diagnosis and Treatment
- Hemoglobinopathies and Related Disorders
- Alcoholism and Thiamine Deficiency
- Abdominal Surgery and Complications
- Congenital heart defects research
- Hernia repair and management
- Thermal Regulation in Medicine
- Cognitive Abilities and Testing
- Coronary Artery Anomalies
- Optical Imaging and Spectroscopy Techniques
Great Ormond Street Hospital
2025
University College London
2025
King's College London
2017-2024
St Thomas' Hospital
2019-2024
NeuroDevelopment Center
2021
University of Trieste
2013-2019
The Developing Human Connectome Project is an Open Science project that provides the first large sample of neonatal functional MRI data with high temporal and spatial resolution. These enable mapping intrinsic connectivity between spatially distributed brain regions under normal adverse perinatal circumstances, offering a framework to study ontogeny large-scale organization in humans. Here, we characterize unprecedented detail maturation integrity resting state networks (RSNs) at...
The Developing Human Connectome Project has created a large open science resource which provides researchers with data for investigating typical and atypical brain development across the perinatal period. It collected 1228 multimodal magnetic resonance imaging (MRI) datasets from 1173 fetal and/or neonatal participants, together collateral demographic, clinical, family, neurocognitive genomic data. All subjects were studied in utero soon after birth on single MRI scanner using specially...
Preterm-born children are at increased risk of lifelong neurodevelopmental difficulties. Group-wise analyses magnetic resonance imaging show many differences between preterm- and term-born infants but do not reliably predict neurocognitive prognosis for individual infants. This might be due to the unrecognized heterogeneity cerebral injury within preterm group. study aimed determine whether atypical brain microstructural development following birth is significantly variable Using Gaussian...
Diffusion MRI offers a unique probe into neural microstructure and connectivity in the developing brain. However, analysis of neonatal brain imaging data is complicated by inevitable subject motion, leading to series scattered slices that need be aligned within across diffusion-weighted contrasts. Here, we develop reconstruction method for slice multi-shell high angular resolution diffusion (HARDI) data, jointly estimating an uncorrupted representation motion parameters at or multiband...
Drug-resistant focal epilepsy is often caused by cortical dysplasias (FCDs). The distribution of these lesions across the cerebral cortex and impact lesion location on clinical presentation surgical outcome are largely unknown. We created a neuroimaging cohort patients with individually mapped FCDs to determine factors associated predictors postsurgical outcome.
Abstract One outstanding challenge for machine learning in diagnostic biomedical imaging is algorithm interpretability. A key application the identification of subtle epileptogenic focal cortical dysplasias (FCDs) from structural MRI. FCDs are difficult to visualize on MRI but often amenable surgical resection. We aimed develop an open-source, interpretable, surface-based machine-learning automatically identify heterogeneous data epilepsy surgery centres worldwide. The Multi-centre Epilepsy...
The aim of this study was to determine the safety and efficacy paediatrician-administered propofol in children undergoing different painful procedures.We conducted a retrospective over 12-year period three Italian hospitals. A specific training protocol developed each institution train paediatricians administering for procedures.In study, 36,516 procedural sedations were performed. Deep sedation achieved all patients. None experienced severe side effects or prolonged hospitalisation. There...
Premature birth occurs during a period of rapid brain growth. In this context, interpreting clinical neuroimaging can be complicated by the typical changes in contrast, size and gyrification occurring background to any pathology. To model describe evolving shape we used Bayesian regression technique, Gaussian process regression, adapted multiple correlated outputs. Using MRI, simultaneously estimated tissue intensity on T1- T2-weighted scans as well local large cohort 408 neonates scanned...
Importance A leading cause of surgically remediable, drug-resistant focal epilepsy is cortical dysplasia (FCD). FCD challenging to visualize and often considered magnetic resonance imaging (MRI) negative. Existing automated methods for detection are limited by high numbers false-positive predictions, hampering their clinical utility. Objective To evaluate the efficacy interpretability graph neural networks in automatically detecting lesions on MRI scans. Design, Setting, Participants In this...
Abstract The Developing Human Connectome Project (dHCP) seeks to create the first 4-dimensional connectome of early life. Understanding this in detail may provide insights into normal as well abnormal patterns brain development. Following established best practices adopted by WU-MINN (HCP), and pioneered FreeSurfer, project utilises cortical surface-based processing pipelines. In paper, we propose a fully automated pipeline for structural Magnetic Resonance Imaging (MRI) developing neonatal...
The diverse cerebral consequences of preterm birth create significant challenges for understanding pathogenesis or predicting later outcome. Instead focusing on describing effects common to the group, comparing individual infants against robust normative data offers a powerful alternative study brain maturation. Here we used Gaussian process regression curves characterizing volumetric development in 274 term-born infants, modeling age at scan and sex. We then compared 89 scanned...
Infants with congenital heart disease are at risk of neurodevelopmental impairments, the origins which currently unclear. This study aimed to characterize relationship between neonatal brain development, cerebral oxygen delivery and outcome in infants disease. A cohort serious or critical (
Abstract Formation of the functional connectome in early life underpins future learning and behavior. However, our understanding how organization brain regions into interconnected hubs (centrality) matures postnatal period is limited, especially response to factors associated with adverse neurodevelopmental outcomes such as preterm birth. We characterized voxel-wise centrality (weighted degree) 366 neonates from Developing Human Connectome Project. tested hypothesis that age at scan...
Abstract The Developing Human Connectome Project (dHCP) is an Open Science project which provides the first large sample of neonatal functional MRI (fMRI) data with high temporal and spatial resolution. This enables mapping intrinsic connectivity between spatially distributed brain regions under normal adverse perinatal circumstances, offering a framework to study ontogeny large-scale organisation in humans. Here, we characterise unprecedented detail maturation integrity resting-state...
Introduction Lung function abnormalities are common in sickle cell anaemia (SCA) but data from sub-Saharan Africa limited. We hypothesised that children with SCA West had worse lung than their counterparts Europe. Methods This prospective cross-sectional study evaluated spirometry and anthropometry black African individuals (haemoglobin phenotype SS) aged 6–18 years Nigeria the UK, when clinically stable. Age-matched controls were also included to validate Global Initiative reference values....
Following birth, infants must immediately process and rapidly adapt to the array of unknown sensory experiences associated with their new ex-utero environment. However, although it is known that unimodal stimuli induce activity in corresponding primary cortices newborn brain, unclear how multimodal are processed integrated across modalities. The latter essential for learning understanding environmental contingencies through encoding relationships between experiences; ultimately likely...
When planning for epilepsy surgery, multiple potential sites resection may be identified through anatomical imaging. Magnetoencephalography (MEG) using optically pumped sensors (OP-MEG) is a non-invasive functional neuroimaging technique which could used to help identify the epileptogenic zone from these candidate regions. Here we test utility of a-priori information imaging differentiating lesion with OP-MEG. We investigate number scenarios: whether use rigid or flexible sensor arrays,...
BACKGROUND AND PURPOSE: Head motion causes image degradation in brain MR imaging examinations, negatively impacting quality, especially pediatric populations. Here, we used a retrospective correction technique children and assessed quality improvement for 3D acquisitions. MATERIALS METHODS: We prospectively acquired at 3T using sequences, T1-weighted MPRAGE, T2-weighted TSE, FLAIR 32 unsedated children, including 7 with epilepsy (age range, 2–18 years). implemented novel through modification...
Purpose The MP2RAGE sequence is typically optimized for either T 1 ‐weighted uniform image (UNI) or gray matter–dominant fluid and white matter suppression (FLAWS) contrast images. Here, the purpose was to optimize an protocol at 7 Tesla provide UNI FLAWS images simultaneously in a clinically applicable acquisition time <0.7 mm isotropic resolution. Methods Using extended phase graph formalism, signal evolution of simulated incorporating 2 relaxation, diffusion, RF spoiling, B +...
Primary adrenal insufficiency (PAI) in children is an uncommon but severe condition which can be either inherited or acquired. It consists clinical manifestation of defective production ineffective action endogenous glucocorticoids; deficiency mineralocorticoids and androgens may coexist. Diagnosis PAI young people challenging; while crisis (acute decompensation) a life-threatening condition, with patient presenting characteristic features hypoglycemia, hypotension, collapse coma, chronic...
Abstract Introduction Quantitative MRI is important for non-invasive tissue characterisation. In previous work we developed a clinically feasible multi-contrast protocol T 1 -weighted imaging based on the MP2RAGE sequence that was optimised both children and adults. It demonstrated range of Fluid And White Matter Suppression (FLAWS) related contrasts could be produced while maintaining uniform image (UNI) quality, challenge at higher field strengths. Here introduce an approach to use these...