A5076856763- Neonatal and fetal brain pathology
- Neonatal Respiratory Health Research
- Fetal and Pediatric Neurological Disorders
- Infant Development and Preterm Care
- Congenital Heart Disease Studies
- Aortic Disease and Treatment Approaches
- Pregnancy and preeclampsia studies
- Preterm Birth and Chorioamnionitis
- Hormonal and reproductive studies
- Coronary Artery Anomalies
- Maternal and Perinatal Health Interventions
- Sexual function and dysfunction studies
- Attention Deficit Hyperactivity Disorder
- Prenatal Screening and Diagnostics
- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Digital Imaging in Medicine
- Intravenous Infusion Technology and Safety
- Metabolism and Genetic Disorders
- Reproductive Health and Contraception
- Multicultural Socio-Legal Studies
- Anatomy and Medical Technology
- Surgical site infection prevention
- Congenital Diaphragmatic Hernia Studies
- Gastroesophageal reflux and treatments
King's College London
2015-2024
St Thomas' Hospital
2015-2024
Guy's and St Thomas' NHS Foundation Trust
2024
Evelina London Children's Healthcare
2020
University of Birmingham
2019
Kings Health Partners
2015
University of Nottingham
2000
Worcestershire Acute Hospitals NHS Trust
2000
National University Hospital
1988-1999
National University of Singapore
1984-1999
The Developing Human Connectome Project has created a large open science resource which provides researchers with data for investigating typical and atypical brain development across the perinatal period. It collected 1228 multimodal magnetic resonance imaging (MRI) datasets from 1173 fetal and/or neonatal participants, together collateral demographic, clinical, family, neurocognitive genomic data. All subjects were studied in utero soon after birth on single MRI scanner using specially...
Preterm birth engenders an increased risk of conditions like cerebral palsy and therefore this time may be crucial for the brain's developing sensori-motor system. However, little is known about how cortical function matures at time, whether development influenced by experience, its role in spontaneous motor behavior. We aimed to systematically characterize spatial temporal maturation functional brain activity across period using MRI a custom-made robotic stimulation device. studied 57...
Objectives Neurodevelopmental impairment has become the most important comorbidity in infants with congenital heart disease (CHD). We aimed to (1) investigate burden of brain lesions CHD prior surgery and (2) explore clinical factors associated injury. Study design Prospective observational study. Setting Single centre UK tertiary neonatal intensive care unit. Patients 70 newborn critical or serious underwent MRI surgery. Main outcome measures Prevalence cerebral injury including arterial...
This study investigated the association between attention-deficit/hyperactivity disorder (ADHD) symptomatology in preschool-aged children who were born very preterm (<33 weeks) and cognitive outcomes, clinical risk socio-demographic characteristics. 119 participated Evaluation of Preterm Imaging Study at term-equivalent age assessed a mean 4.5 years. Parents completed ADHD Rating Scale IV, norm-referenced checklist that evaluates according to diagnostic criteria, Behavior Inventory Executive...
<h3>BACKGROUND AND PURPOSE:</h3> Brain MR imaging at term-equivalent age is a useful tool to define brain injury in preterm infants. We report pragmatic clinical radiological assessment of images from large unselected cohort infants imaged term and document the spectrum frequency acquired lesions their relation outcomes 20 months. <h3>MATERIALS METHODS:</h3> Infants born <33 weeks' gestation were recruited South North West London neonatal units single center 3T age. At months' corrected...
The diverse cerebral consequences of preterm birth create significant challenges for understanding pathogenesis or predicting later outcome. Instead focusing on describing effects common to the group, comparing individual infants against robust normative data offers a powerful alternative study brain maturation. Here we used Gaussian process regression curves characterizing volumetric development in 274 term-born infants, modeling age at scan and sex. We then compared 89 scanned...
<h3>BACKGROUND AND PURPOSE:</h3> A uniform description of brain MR imaging findings in infants with severe congenital heart disease to assess risk factors, predict outcome, and compare centers is lacking. Our objective was uniformly describe the spectrum perioperative disease. <h3>MATERIALS METHODS:</h3> Prospective observational studies were performed at 3 European between 2009 2019. Brain preoperatively and/or postoperatively transposition great arteries, single-ventricle physiology, or...
Interpretation of incidental findings on term neonatal MRI brain imaging can be challenging as there is a paucity published normative data asymptomatic neonates. Reporting radiologists and clinicians need to familiar with these avoid over-investigation misinterpretation particularly in relation neurodevelopmental outcome. This study aimed determine the prevalence large group neonates participating Developing Human Connectome Project (dHCP) who were invited for assessment at 18 months.We...
Background: The detailed assessment of fetal brain maturation and development involves morphological evaluation, gyration analysis, reliable biometric measurements. Manual measurements on conventional 2-D magnetic resonance imaging (MRI) are affected by motion there is no clear consensus regarding definitions for parameters anatomical landmark placements, making consistent reference plane slice selection challenging. Automated biometry with 3-D slice-to-volume reconstruction (SVR) has the...
Infants with congenital heart disease are at risk of brain injury and impaired neurodevelopment. The aim was to investigate factors for perioperative lesions in infants disease.Infants transposition the great arteries, single ventricle physiology, left ventricular outflow tract and/or aortic arch obstruction undergoing cardiac surgery <6 weeks after birth from 3 European cohorts (Utrecht, Zurich, London) were combined. Brain scored on preoperative (transposition arteries N=104; physiology...
To examine the relationship between perioperative brain injury and neurodevelopment during early childhood in patients with severe congenital heart disease (CHD).
Fetal and neonatal glucose lactate levels acid-base balance after continuous maternal infusion of 5% dextrose at 180 mL/h (9 g/h) was compared with 0.9% saline solution in a prospective, randomized study from selected monitored labors. An produced significantly increased (p < 0.01), cord artery vein 0.001) blood. insulin level also present 0.05), but no differences were observed. β-Hydroxybutyrate lower 0.05) not blood, infusion. No significant changes occurred blood between the two groups...
Abstract This study investigated the association between attention-deficit/hyperactivity disorder (ADHD) symptomatology in preschool-aged children who were born very preterm (<32 weeks) and cognitive outcomes, clinical risk socio-demographic characteristics. 119 participated Evaluation of Preterm Imaging Study at term-equivalent age assessed a mean 4.5 years. Parents completed ADHD Rating Scale IV, norm-referenced checklist that evaluates according to diagnostic criteria, Behavior...
ABSTRACT Objectives Evaluating craniofacial phenotype-genotype correlations prenatally is increasingly important; however, it subjective and challenging with 3D ultrasound. We developed an automated landmark propagation pipeline using motion-corrected, slice-to-volume reconstructed (SVR) fetal MRI for measurements. Methods A literature review expert consensus identified 31 biometrics MRI. An atlas defined anatomical landmarks served as a template subject registration, auto-labelling,...