A5035958199- Neonatal and fetal brain pathology
- Infant Development and Preterm Care
- Congenital Heart Disease Studies
- Fetal and Pediatric Neurological Disorders
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Neonatal Respiratory Health Research
- Infectious Encephalopathies and Encephalitis
- Preterm Birth and Chorioamnionitis
- Glioma Diagnosis and Treatment
- Pelvic and Acetabular Injuries
- Cardiac, Anesthesia and Surgical Outcomes
- Hearing, Cochlea, Tinnitus, Genetics
- Vascular Malformations and Hemangiomas
- Epilepsy research and treatment
- interferon and immune responses
- Metabolism and Genetic Disorders
- Meningioma and schwannoma management
- Histiocytic Disorders and Treatments
- Long-Term Effects of COVID-19
- Facial Nerve Paralysis Treatment and Research
- Vestibular and auditory disorders
- Atomic and Subatomic Physics Research
- Congenital heart defects research
King's College London
2020-2024
Great Ormond Street Hospital for Children NHS Foundation Trust
2018-2023
National Health Service
2021
King's College Hospital NHS Foundation Trust
2021
St George’s University Hospitals NHS Foundation Trust
2018
Great Ormond Street Hospital
2016
University College London
2016
Ollscoil na Gaillimhe – University of Galway
2013
University Hospital Galway
2013
The Developing Human Connectome Project has created a large open science resource which provides researchers with data for investigating typical and atypical brain development across the perinatal period. It collected 1228 multimodal magnetic resonance imaging (MRI) datasets from 1173 fetal and/or neonatal participants, together collateral demographic, clinical, family, neurocognitive genomic data. All subjects were studied in utero soon after birth on single MRI scanner using specially...
Preterm-born children are at increased risk of lifelong neurodevelopmental difficulties. Group-wise analyses magnetic resonance imaging show many differences between preterm- and term-born infants but do not reliably predict neurocognitive prognosis for individual infants. This might be due to the unrecognized heterogeneity cerebral injury within preterm group. study aimed determine whether atypical brain microstructural development following birth is significantly variable Using Gaussian...
The dynamic nature and complexity of the cellular events that take place during last trimester pregnancy make developing cortex particularly vulnerable to perturbations. Abrupt interruption normal gestation can lead significant deviations many these processes, resulting in atypical trajectory cortical maturation preterm birth survivors. We sought first map typical micro- macrostructure development using invivo MRI a large sample healthy term-born infants scanned after (n = 259). Then we...
The diverse cerebral consequences of preterm birth create significant challenges for understanding pathogenesis or predicting later outcome. Instead focusing on describing effects common to the group, comparing individual infants against robust normative data offers a powerful alternative study brain maturation. Here we used Gaussian process regression curves characterizing volumetric development in 274 term-born infants, modeling age at scan and sex. We then compared 89 scanned...
Infants with congenital heart disease are at risk of neurodevelopmental impairments, the origins which currently unclear. This study aimed to characterize relationship between neonatal brain development, cerebral oxygen delivery and outcome in infants disease. A cohort serious or critical (
Interpretation of incidental findings on term neonatal MRI brain imaging can be challenging as there is a paucity published normative data asymptomatic neonates. Reporting radiologists and clinicians need to familiar with these avoid over-investigation misinterpretation particularly in relation neurodevelopmental outcome. This study aimed determine the prevalence large group neonates participating Developing Human Connectome Project (dHCP) who were invited for assessment at 18 months.We...
Background Infants with congenital heart disease (CHD) are at risk of neurodevelopmental impairments, which may be associated impaired brain growth. We characterized how perioperative growth in infants CHD deviates from typical trajectories and assessed the relationship between individualized clinical factors. Methods Results A total 36 underwent preoperative postoperative magnetic resonance imaging. Regional volumes were extracted. Normative volumetric development curves generated using...
To assess whether there was any relationship between the number of clinical markers for spinal dysraphism and its presence on ultrasound an isolated sacral dimple dysraphism. Outcomes further imaging were also examined.All patients who underwent (SUS) in University Hospital Galway (UHG) over a 5-year period (2006-2011) identified. Patients excluded based age (>14 years old excluded) indication (only being investigated suspected included). Indications imaging, results information accessed...
<h3>BACKGROUND AND PURPOSE:</h3> It has been hypothesized that skull marrow signal alteration may represent an early disease manifestation of Sturge-Weber syndrome before development its intracranial manifestations. We alternatively intraosseous changes are associated with the overlying port-wine stain rather than stigmata and hence not a predictor brain involvement. <h3>MATERIALS METHODS:</h3> MR imaging children presenting and/or between 1998 2017 was evaluated by 2 pediatric...
BACKGROUND AND PURPOSE: Head motion causes image degradation in brain MR imaging examinations, negatively impacting quality, especially pediatric populations. Here, we used a retrospective correction technique children and assessed quality improvement for 3D acquisitions. MATERIALS METHODS: We prospectively acquired at 3T using sequences, T1-weighted MPRAGE, T2-weighted TSE, FLAIR 32 unsedated children, including 7 with epilepsy (age range, 2–18 years). implemented novel through modification...
With increasing neuroimaging applications of contemporary three-dimensional T1W fast spin echo (3D FSE) sequences, it was aimed to reappraise the normal patterns skull base facial nerve gadolinium enhancement.Pre- and post-gadolinium 3D imaging studies (n = 64) were retrospectively analysed in patients without suspected pathology. Two independent observers scored signal at each six segments. Wilcoxon signed-rank test used compare changes between pre- sequences location, how this differed...
Infants with congenital heart disease (CHD) are at risk of neurodevelopmental impairments, which may be associated impaired brain growth. We mapped volumes from pre- and postoperative MRI in 36 infants CHD undergoing cardiac surgery or intervention to normative curves derived 219 healthy infants. Perioperative growth was impaired, clinical surgical factors, including higher preoperative serum creatinine levels, older postnatal age surgery, longer cardiopulmonary bypass duration intensive...
Abstract Background and Objectives Epileptogenic lesions in focal epilepsy can be subtle or undetected on conventional brain MRI. Ultra-high field (7T) MRI offers higher spatial resolution, contrast signal-to-noise ratio compared to imaging systems has shown promise the presurgical evaluation of adult epilepsy. However, utility ultra-high paediatric epilepsy, where malformations cortical development are more common, is unclear. This study 7T 3T children with by comparing: (i) scan...
Abstract The diverse cerebral consequences of preterm birth create significant challenges for understanding pathogenesis or predicting later outcome. Instead focusing on describing effects common to the group, comparing individual infants against robust normative data offers a powerful alternative study brain maturation. Here we used Gaussian process regression curves characterising volumetric development in 274 term-born infants, modelling age at scan and sex. We then compared 89 scanned...
Abstract Introduction The dynamic nature and complexity of the cellular events that take place during last trimester pregnancy make developing cortex particularly vulnerable to perturbations. Abrupt interruption normal gestation can lead significant deviations many these processes, resulting in atypical trajectory cortical maturation preterm birth survivors. Methods We sought first map typical micro macrostructure development using invivo MRI a large sample healthy term-born infants scanned...