A5058467499- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Congenital heart defects research
- Fetal and Pediatric Neurological Disorders
- MRI in cancer diagnosis
- Autopsy Techniques and Outcomes
- Advanced NMR Techniques and Applications
- Medical Imaging Techniques and Applications
- Multiple Sclerosis Research Studies
- Cerebral Venous Sinus Thrombosis
- Photoacoustic and Ultrasonic Imaging
- Thermography and Photoacoustic Techniques
- Vestibular and auditory disorders
- Electron Spin Resonance Studies
- Ultrasound Imaging and Elastography
- Genomic variations and chromosomal abnormalities
- Down syndrome and intellectual disability research
- Epilepsy research and treatment
- Vasculitis and related conditions
- Ultrasound and Hyperthermia Applications
- Peripheral Neuropathies and Disorders
- Coronary Artery Anomalies
- Sarcoidosis and Beryllium Toxicity Research
- Neurological disorders and treatments
- Congenital Heart Disease Studies
King's College London
2024-2025
Guy's and St Thomas' NHS Foundation Trust
2018-2025
The University of Melbourne
2014-2021
University College London
2009-2020
Royal Free London NHS Foundation Trust
2016
CAB International
2010
Lancet Laboratories
2009
Great Ormond Street Hospital
2009
University College Hospital
2009
MRC Prion Unit
2009
The ability to noninvasively image embryonic vascular anatomy in mouse models is an important requirement for characterizing the development of normal cardiovascular system and malformations heart supply. Photoacoustic imaging, which can provide high resolution non invasive images vasculature based upon optical absorption by endogenous hemoglobin, well suited this application. In study, photoacoustic embryos were obtained ex vivo vivo. show intricate details depths up 10 mm, allowed whole be...
Abstract Objectives Glutaric aciduria type 1 (GA1) is a rare autosomal recessive organic acidaemia caused by deficiency of the glutaryl-CoA dehydrogenase enzyme. We describe outcomes following deep brain stimulation (DBS) for management dystonia children and adults with glutaric (GA1). Methods Cases GA1 were identified from institutional databases two tertiary movement disorder services. Data extracted clinical records using standardised proforma, including baseline characteristics, imaging...
Purpose To demonstrate simultaneous T 1 ‐weighted imaging, mapping, SWI, and QSM from a single multi‐echo (ME) MP2RAGE acquisition. Methods A single‐echo (SE) sequence at 7 tesla was extended to ME with 4 bipolar gradient echo readouts. images maps calculated individual echoes were combined using sum of squares averaged, respectively. ME‐combined SWI associated minimum intensity projection generated TE‐adjusted homodyne filters. reconstruction pipeline used, including phase‐offsets...
Microscopic MRI (microMRI) is an emerging technique for high-throughput phenotyping of transgenic mouse embryos, and capable visualising abnormalities in cardiac development. To identify defects we have optimised embryo preparation MR acquisition parameters to maximise image quality assess the phenotypic changes chromodomain helicase DNA-binding protein 7 (Chd7) mice. microMRI methods rely on tissue penetration with a gadolinium chelate contrast agent reduce T(1), thus improving...
Extensive worldwide efforts are underway to produce knockout mice for each of the ~25,000 mouse genes, which may give new insights into underlying pathophysiology neurological disease. Microscopic magnetic resonance imaging (μMRI) is a key method non-invasive morphological phenotyping, capable producing high-resolution 3D images ex-vivo brains, after fixation with an MR contrast agent. These agents have been suggested act as active-stains, enhancing structures not normally visible on MRI. In...
Purpose This work demonstrates a 3D radial multi‐echo acquisition scheme for time‐efficient sodium ( 23 Na) MR‐signal and analysis. Echo reconstructions were used to produce signal‐to‐noise ratio (SNR)‐enhanced Na‐images parameter maps of the biexponential observed transverse relaxation time ) decay. Methods A custom‐built sequence was proposed series volumetric Na‐images. Measurements acquired in phantom vivo human brains analyzed SNR enhancement multi‐component estimation. Results Rapid...
Abstract Purpose To establish the accuracy, intra‐ and inter‐observer variabilities of four different segmentation methods for measuring cardiac functional parameters in healthy infarcted rat hearts. Materials Methods Six Wistar rats were imaged before after myocardial infarction using an electrocardiogram respiratory‐gated spoiled gradient echo sequence. Blinded randomized datasets analyzed by various semi‐automatic manual to compare their measurement bias variability. In addition, accuracy...
We describe a fully automated pipeline for the morphometric phenotyping of mouse brains from μMRI data, and show its application to Tc1 model Down syndrome, identify new morphological phenotypes in brain this first transchromosomic animal carrying human chromosome 21. incorporate an accessible approach simultaneously scanning multiple ex vivo brains, requiring only 3D-printed holder, novel image processing steps their separation orientation. employ clinically established multi-atlas...
Multiple sclerosis is a neuroinflammatory disease of the CNS that associated with significant irreversible neuro-axonal loss, leading to permanent disability. There thus an urgent need for
Radiolabelled somatostatin analogues detect neuroendocrine tumours (NETs), but may reveal other tumour types. We examined the prevalence of possible meningioma in patients with known or suspected NETs imaged Ga-DOTATATE PET-computed tomography (CT) on basis central nervous system uptake and compared findings magnetic resonance contrast-enhanced CT imaging.Retrospective imaging reports from 313 who had undergone PET for primary repeat NET staging were searched to identify meningiomas PET....
Purpose The clinical application of sodium MRI is hampered due to relatively low image quality and associated long acquisition times. Compressed sensing (CS) aims at a reduction measurement time, but has been found encompass quantitative estimation bias when used in SNR x‐Nuclei imaging. This work analyses CS human brain from undersampled acquisitions provides recommendations for tissue concentration (TSC) estimation. Methods reconstructions 3D radial 5 healthy volunteers were investigated...
Abstract Effective methods for high‐throughput screening and morphometric analysis are crucial phenotyping the increasing number of mouse mutants that being generated. Automated segmentation propagation embryo is an emerging application enables noninvasive rapid quantification substructure volumetric data analysis. We present a study to assess validate accuracy brain kidney volumes generated via in ex vivo MRI atlas comprising three different groups against current “gold standard”—manual...
Purpose: We aimed to image the optic nerve, subarachnoid space and nerve sheath in emmetropes myopes ultra-high field (7-Tesla) magnetic resonance imaging (MRI). targeted retrobulbar distance of approximately 3 mm behind eyeball, an area clinical interest because distensibility pressure-related enlargement. Methods: Eleven (+0.75 −0.50D, aged 20–41 years) 10 (−4.5 −12D, 21–37 participated. Cross-sectional at eye were measured from two-dimensional T2-weighted coronal oblique MRI images...
Abstract Tuberculous meningitis (TBM) is the most lethal form of tuberculosis. Clinical features, such as coma, can predict death, but they are insufficient for accurate prognosis other outcomes, especially when impacted by co-morbidities HIV infection. Brain magnetic resonance imaging (MRI) characterises extent and severity disease may enable more prediction complications poor outcomes. We analysed clinical brain MRI data from a prospective longitudinal study 216 adults with TBM; 73 (34%)...
To develop a 3D distortion-free reduced-FOV diffusion-prepared gradient-echo sequence and demonstrate its application in vivo for diffusion imaging of the spinal cord healthy volunteers. A multi-shot acquisition is achieved using slice-selective tip-down pulse phase-encoding direction preparation, combined with magnitude stabilizers, centric k-space encoding, 2D phase navigators to correct intershot errors. The accuracy ADC values obtained proposed approach was evaluated phantom compared...
Abstract Upper and lower limb impairments are common in people with multiple sclerosis (pwMS), yet difficult to clinically identify early stages of disease progression. Tasks involving complex motor control can potentially reveal more subtle deficits stages, be performed during functional MRI (fMRI) acquisition, investigate underlying neural mechanisms, providing markers for We investigated brain activation visually guided force matching hand or foot 28 minimally disabled pwMS (Expanded...
Purpose: Worldwide efforts to understand developmental processes demand new high‐resolution 3D imaging methods detect the consequences of gene function in embryo development and diseases. Encouragingly, recent studies have shown that MRI contrast agents can highlight specific tissue structures ex vivo adult mouse brains. MR embryos is currently limited by a lack staining capabilities would provide flexibility specificity offered histological stains conventionally used for phenotyping....
The preferential absorption of near infrared light by blood makes photoacoustic imaging well suited to visualising vascular structures in soft tissue. In addition, the spectroscopic specificity tissue chromophores can be exploited acquiring images at multiple excitation wavelengths. This allows quantification endogenous chromophores, such as oxy- and deoxyhaemoglobin, hence oxygenation, detection exogenous functionalised contrast agents. More importantly, this approach has potential...
Parameter mapping in sodium MRI data is challenging due to inherently low SNR and spatial resolution, prompting the need employ robust models estimation techniques. This work aims develop a continuum model of T2* -decay overcome limitations commonly employed bi-exponential models. Estimates mean fast component fraction tissue are emergent from inferred model.A closed-form was derived assuming gamma distribution components. Sodium performed on four healthy human subjects phantom consisting...