A5018795593- MRI in cancer diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Complex Systems and Decision Making
- Lung Cancer Diagnosis and Treatment
- Heparin-Induced Thrombocytopenia and Thrombosis
- Intelligent Tutoring Systems and Adaptive Learning
- Radiology practices and education
- Experimental Learning in Engineering
- Venous Thromboembolism Diagnosis and Management
- Medical Imaging and Pathology Studies
- Platelet Disorders and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Mechanisms and Therapy
- Acute Myocardial Infarction Research
- Cardiovascular Health and Risk Factors
- DNA Repair Mechanisms
- Dental Education, Practice, Research
- Healthcare Systems and Public Health
- PARP inhibition in cancer therapy
- Neuroblastoma Research and Treatments
- Cancer Genomics and Diagnostics
- BRCA gene mutations in cancer
- Pleural and Pulmonary Diseases
- Pancreatic and Hepatic Oncology Research
- Parathyroid Disorders and Treatments
Institute of Cancer Research
2023-2025
Breast Cancer Now
2023-2025
Response Biomedical (Canada)
2024
Target (United States)
2024
University College London
2015-2023
Royal Marsden Hospital
2023
Society of Interventional Radiology
2023
American College
2023
University College Hospital
2019-2022
University College London Hospitals NHS Foundation Trust
2021-2022
Resistance to therapies that target homologous recombination deficiency (HRD) in breast cancer limits their overall effectiveness. Multiple, preclinically validated, mechanisms of resistance have been proposed, but existence and relative frequency clinical disease are unclear, as is how resistance.
Identification of ARID1A/ATR synthetic lethality led to ATR inhibitor phase II trials in ovarian clear cell carcinoma (OCCC), a cancer unmet need. Using multiple CRISPR-Cas9 mutagenesis and interference screens, we show that inactivation protein phosphatase 2A (PP2A) subunits, including PPP2R1A, enhance ATRi sensitivity ARID1A mutant OCCC. Analysis new OCCC cohort indicates 52% possess oncogenic PPP2R1A p.R183 mutations these, one half possessed both as well mutations. CRISPR-prime editing...
Antagonism of αvβ6 is emerging as a potential treatment idiopathic pulmonary fibrosis based on strong target validation. Starting from an αvβ3 antagonist lead and through simple variation in the nature position aryl substituent, discovery compounds with improved activity described. The also have physicochemical properties commensurate oral bioavailability are high quality starting points for drug program. Compounds 33S 43E1 pan αv antagonists having ca. 100 nM potency against αvβ3, αvβ5,...
Radiolabelled somatostatin analogues detect neuroendocrine tumours (NETs), but may reveal other tumour types. We examined the prevalence of possible meningioma in patients with known or suspected NETs imaged Ga-DOTATATE PET-computed tomography (CT) on basis central nervous system uptake and compared findings magnetic resonance contrast-enhanced CT imaging.Retrospective imaging reports from 313 who had undergone PET for primary repeat NET staging were searched to identify meningiomas PET....
Vaccination strategies have been at the forefront of controlling COVID-19 pandemic. An association between vaccine-induced immune thrombotic thrombocytopenia (VITT) and one these vaccines, ChAdOx1 nCov-19 vaccine, is now recognized. The purpose this study was to investigate frequency location thrombosis in each vascular system using CT, MRI, US identify additional sites thrombus a United Kingdom-wide sample patients with confirmed VITT. Thirty-two radiology centers identified through...
Objective: To compare key characteristics of interventional radiology (IR) training in the UK with four other English-speaking countries (USA, Canada, Australia and New Zealand) summarise requirements for training. Methods: Main features examined were career pathway requirements, examinations required, specific competition IR process applying as an international medical graduate. Data collected from official governing body publications, literature personal experience. Results: Several...
Evaluate equilibrium contrast-enhanced CT (EQ-CT) texture analysis (EQ-CTTA) against histologically-quantified fibrosis, serum-based enhanced liver fibrosis panel (ELF) and imaging-based extracellular volume fraction (ECV) in chronic hepatitis.This study was a re-analysis of image data from previous prospective study. Pre- equilibrium-phase post-IV contrast datasets were collected patients with hepatitis contemporaneous biopsy serum ELF measurement between April 2011 July 2013. Biopsy...
Background To test the principles underpinning equilibrium contrast imaging estimation of tissue extracellular volume (ECV) fraction, using a three‐dimensional (3D) engineered model with known cellular and volumes. Methods Six 3D models (tumoroids) consisting cell cultures within collagen containing hydrogel were constructed after culture centrifugation direct measurement component volume. Measured tumoroid ECV ranged from 0.89 to 1. was calculated measuring T1 relaxation time at 3 Tesla...
Background: A rare prothrombotic syndrome, termed vaccine-induced immune thrombotic thrombocytopaenia (VITT) has been described following administration of the first ChAdOx1 nCov-19 (Astrazeneca) vaccine. Patients present with thrombosis in multiple sites. Targeted imaging is key to diagnosing thrombus organ or system localising symptoms, and early accurate identification extent multiplicity occult thromboses other vascular systems required best manage these patients. Methods: We performed a...
Patients with primary or metastatic solid tumours can be treated minimally invasive image-guided procedures as an alternative to surgical resection. Reducing organ motion during these is crucial so that accurately targeted and treatment delivered within a small margin, limiting potential damage adjacent structures. As ventilation the main cause of motion, there has been shift from conventional towards use in-circuit high-frequency jet techniques for procedures. We present case 7-year-old who...
<h3>Introduction</h3> The GRACE score predicts in-hospital mortality and is a key tool in the risk stratification of patients with non ST-elevation acute coronary syndrome (ACS). This then determines treatment timing any intervention such as PCI (1). We developed an ACS pathway based on these guidelines incorporating score, serial troponin, ECG changes presenting symptoms order to categorise into high, intermediate low (Figure 1). <h3>Methods</h3> Based discharge summary coding all NSTE-ACS...
This thesis describes the design and testing of a videoconferencing system for supporting academic social needs hospitalized high school students. The underlying technologies PEBBLES (Providing Education by Bringing Learning Environments to Students) were incorporated into High School Prototype (HSPP) with new functionality such as application sharing whiteboard. Laboratory studies conducted four groups students in simulated classroom/hospital environment, assigning them storyboarding task...
This thesis describes the design and testing of a videoconferencing system for supporting academic social needs hospitalized high school students. The underlying technologies PEBBLES (Providing Education by Bringing Learning Environments to Students) were incorporated into High School Prototype (HSPP) with new functionality such as application sharing whiteboard. Laboratory studies conducted four groups students in simulated classroom/hospital environment, assigning them storyboarding task...