A5002332701- Hepatocellular Carcinoma Treatment and Prognosis
- Extracellular vesicles in disease
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- Cancer, Hypoxia, and Metabolism
- Vascular Malformations and Hemangiomas
- Cancer, Stress, Anesthesia, and Immune Response
- Intracranial Aneurysms: Treatment and Complications
- Renal cell carcinoma treatment
- Anesthesia and Neurotoxicity Research
- Ultrasound and Hyperthermia Applications
- Inflammatory Biomarkers in Disease Prognosis
- Immune Cell Function and Interaction
- Colorectal Cancer Treatments and Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Immune cells in cancer
- Liver physiology and pathology
- Metabolomics and Mass Spectrometry Studies
- Ocular Oncology and Treatments
- Histiocytic Disorders and Treatments
- Immunotherapy and Immune Responses
- Cancer, Lipids, and Metabolism
Ludwig-Maximilians-Universität München
2022-2025
LMU Klinikum
2022-2025
Istanbul Eye Hospital
2025
Society of Interventional Radiology
2023
American College
2023
Abstract Purpose: SORAMIC is a randomized controlled trial in patients with advanced hepatocellular carcinoma (HCC) undergoing sorafenib ± selective internal radiation therapy (SIRT). We investigated the value of extracellular vesicle (EV)-based proteomics for treatment response prediction. Experimental Design: The analysis population comprised 25 receiving SIRT+sorafenib and 20 alone. Patients were classified as responders or nonresponders based on changes AFP imaging overall survival....
Oxidative stress plays a pivotal role in the pathogenesis of Down syndrome (Trisomy 21), as chromosome 21 harbors multiple genes involved redox homeostasis and antioxidant defense mechanisms. This study aimed to evaluate roles transcription factors nuclear factor erythroid 2-related 2 (NRF2) factor-kappa B (NFKB), along with enzymes cystathionine-γ-lyase (CSE) NAD(P)H dehydrogenase [quinone] 1 (NQO1) amniotic fluid (AF) maternal serum (MS) potential biomarkers for prenatal screening (DS)....
Background & AimsTo explore the predictive value of systemic inflammatory markers (neutrophil-to-lymphocyte ratio [NLR] and platelet-to-lymphocyte [PLR]) in patients with advanced HCC treated sorafenib monotherapy or selective internal radiation therapy (SIRT)/sorafenib combination.MethodsPatients randomized to SIRT/sorafenib within per-protocol population SORAMIC trial were evaluated this exploratory post-hoc analysis. The median baseline NLR PLR used as cut-off values describe subgroups....
PurposeTo assess immunogenic effects in unembolized contralateral tumor after single lobar yttrium-90 transarterial radioembolization (90Y-TARE) of colorectal liver metastases (CRLMs).Material and MethodsThe analysis comprised 10 patients with microsatellite stable (MSS) CRLM scheduled for staged treatment the prospective AROMA trial. Eligibility criteria included bilobar metastatic disease >5 lesions without any within 3 weeks. Baseline biopsy was followed by initial 90Y-TARE 1 lobe, a...
MRI guidance offers better lesion targeting for microwave ablation of liver lesions with higher soft-tissue contrast, as well the possibility real-time thermometry. This study aims to evaluate correlation MR thermometry-predicted volume zone in postprocedural first-day images.
Abstract Purpose The role of microRNA-146a (miR-146a) in defining the tumor immune microenvironment (TIME) is well established. aim this study was to evaluate circulating miR-146a as an early prognostic marker 90 Y-radioembolization ( Y-RE) metastatic liver cancer and assess correlation between TIME cellular composition distant, yet untreated metastases. Methods Twenty-one patients with bilobar lesions from gastro-intestinal underwent lobar Y-RE. Biopsy contralateral lobe abscopal tumors...
Biomarkers are essential to implement personalized therapies in cancer treatment options. As primary liver tumors increasing and is coupled function activation of systemic cells the immune system, we investigated blood-based for their ability predict response local ablative therapy.We analyzed peripheral blood 20 patients with at baseline following brachytherapy. In addition platelets, leukocytes, lymphocytes, monocytes, neutrophils most common ratios PLR, LMR, NMR NLR, T cell NKT...
Background Neuroprotective agents are needed to reduce cerebral damage during surgical or neurointerventional procedures including stroke patients. Purpose To evaluate if thiopental can be used as a neuroprotective agent when injected intra-arterially in transient ischemia model. Material and Methods In total, 24 rabbits were studied four groups of six animals. Group 1 served the control group. group 2, was obtained by intracarotid administration degradable starch microspheres (DSM). 3...
To determine the potential prognostic value of proliferation and angiogenesis plasma proteins following CT-guided high dose rate brachytherapy (HDR-BT) hepatocellular carcinoma (HCC).
Molecular changes in HCC development are largely unknown. As the liver plays a fundamental role body's metabolism, metabolic to be expected. We aimed identify metabolomic comparison cirrhosis (LC) patients, which could potentially serve as novel biomarkers for diagnosis and prognosis. Metabolite expression from 38 SORAMIC trial 32 LC patients were analyzed by mass spectrometry. Metabolites with significant differences between at baseline regarding over follow-up. In addition, association...
Local ablative therapies are established treatment modalities in the of early- and intermediate-stage hepatocellular carcinoma (HCC). Systemic effects local ablation on circulating immune cells may contribute to patients' response. Depending their activation, myeloid able trigger HCC progression as well support anti-tumor immunity. Certain priming monocytes already occur while still circulation. By using flow cytometry, we analyzed peripheral blood monocyte cell populations from a...
Supplementary Data from Extracellular Vesicles May Predict Response to Radioembolization and Sorafenib Treatment in Advanced Hepatocellular Carcinoma: An Exploratory Analysis the SORAMIC Trial
Supplementary Data from Extracellular Vesicles May Predict Response to Radioembolization and Sorafenib Treatment in Advanced Hepatocellular Carcinoma: An Exploratory Analysis the SORAMIC Trial
<div>AbstractPurpose:<p>SORAMIC is a randomized controlled trial in patients with advanced hepatocellular carcinoma (HCC) undergoing sorafenib ± selective internal radiation therapy (SIRT). We investigated the value of extracellular vesicle (EV)-based proteomics for treatment response prediction.</p>Experimental Design:<p>The analysis population comprised 25 receiving SIRT+sorafenib and 20 alone. Patients were classified as responders or nonresponders based on changes...
<div>AbstractPurpose:<p>SORAMIC is a randomized controlled trial in patients with advanced hepatocellular carcinoma (HCC) undergoing sorafenib ± selective internal radiation therapy (SIRT). We investigated the value of extracellular vesicle (EV)-based proteomics for treatment response prediction.</p>Experimental Design:<p>The analysis population comprised 25 receiving SIRT+sorafenib and 20 alone. Patients were classified as responders or nonresponders based on changes...