A5083676325- Multiple Sclerosis Research Studies
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Intracerebral and Subarachnoid Hemorrhage Research
- Genetic Neurodegenerative Diseases
- Neurological disorders and treatments
- Ultrasound and Hyperthermia Applications
- Peripheral Neuropathies and Disorders
- Acute Ischemic Stroke Management
- Polyomavirus and related diseases
- Hereditary Neurological Disorders
- Parkinson's Disease Mechanisms and Treatments
- Muscle Physiology and Disorders
- Systemic Lupus Erythematosus Research
- Cerebrospinal fluid and hydrocephalus
- MRI in cancer diagnosis
- Epilepsy research and treatment
- Neurosurgical Procedures and Complications
- Vestibular and auditory disorders
- Neurogenetic and Muscular Disorders Research
- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Ophthalmology and Eye Disorders
- RNA regulation and disease
- Intracranial Aneurysms: Treatment and Complications
University College London
2016-2025
National Hospital for Neurology and Neurosurgery
2016-2025
University College London Hospitals NHS Foundation Trust
2008-2025
Queen Mary University of London
2008-2024
Pitié-Salpêtrière Hospital
2024
Sorbonne Université
2024
Assistance Publique – Hôpitaux de Paris
2024
Inserm
2024
Institut du Cerveau
2024
Centre National de la Recherche Scientifique
2024
Using functional magnetic resonance imaging (fMRI) we have evaluated the anatomical location of motor hand area. The segment precentral gyrus that most often contained function was a knob-like structure, is shaped like an omega or epsilon in axial plane and hook sagittal plane. On cortical surface cadaver specimens this knob corresponded precisely to characteristic 'middle knee' central sulcus has been described by various anatomists last century. We were then able show reliable landmark for...
Brain microbleeds on gradient-recalled echo (GRE) T2*-weighted MRI may be a useful biomarker for bleeding-prone small vessel diseases, with potential relevance diagnosis, prognosis (especially antithrombotic-related bleeding risk), and understanding mechanisms of symptoms, including cognitive impairment. To address these questions, it is necessary to reliably measure their presence distribution in the brain. We designed systematically validated Microbleed Anatomical Rating Scale (MARS)....
Functional magnetic resonance imaging blood-oxygenation-level-dependent (BOLD) signal increases (activations) and BOLD decreases (“deactivations”) were compared in six healthy volunteers during galvanic vestibular (mastoid) cutaneous (neck) stimulation order to differentiate from ocular motor nociceptive functions. By calculating the contrast for activation minus group, we found activations anterior parts of insula, paramedian dorsolateral thalamus, putamen, inferior parietal lobule...
In a 2-year, placebo-controlled trial (the Natalizumab Safety and Efficacy in Relapsing Remitting Multiple Sclerosis [AFFIRM] study), involving 942 patients with relapsing multiple sclerosis (MS), natalizumab significantly reduced the relapse rate by 68% progression of sustained disability 42% vs placebo. We report effect on MRI measures from AFFIRM study.The number volume gadolinium (Gd)-enhancing, new or enlarging T2-hyperintense, T1-hypointense lesions brain parenchymal fraction were...
Abstract Unfixed and fixed postmortem multiple sclerosis (MS) brain is being used to probe pathology underlying quantitative MR (qMR) changes. Effects of fixation on qMR indices in MS are unknown. In 15 slices T 1 , 2 MT ratio (MTR), macromolecular proton fraction (f B ), fractional anisotropy (FA), mean, axial, radial diffusivity (MD, D ax rad ) were assessed white matter (WM) lesions (WML) normal appearing WM (NAWM) before after formalin. Myelin content, axonal count, gliosis quantified...
<h3>Background:</h3> Different double inversion recovery (DIR) sequences are currently used in multiple sclerosis (MS) research centers to visualize cortical lesions, making it difficult compare published data. This study aimed formulate consensus recommendations for scoring lesions patients with MS, using DIR images acquired 6 European according local protocols. <h3>Methods:</h3> Consensus were formulated and tested a multinational meeting. <h3>Results:</h3> Cortical defined as focal...
In recent years, criteria for the diagnosis of multiple sclerosis (MS) have changed, mainly due to incorporation new MRI criteria. While are a logical step forward, they complex and—not surprisingly—a good working knowledge them is not always evident among neurologists and neuroradiologists. some circumstances, several examinations needed achieve an accurate prompt diagnosis. This provides incentive continued efforts refine MRI-derived information into diagnostic workup patients presenting...
Cerebral microbleeds are a potential neuroimaging biomarker of cerebral small vessel diseases that prone to intracranial bleeding. We aimed determine whether presence can identify patients at high risk symptomatic haemorrhage when anticoagulated for atrial fibrillation after recent ischaemic stroke or transient attack.
Depleted of dopamine, the dynamics parkinsonian brain impact on both 'action' and 'resting' motor behaviour. Deep stimulation has become an established means managing these symptoms, although its mechanisms action remain unclear. Non-invasive characterizations induced responses, effective connectivity underlying them, generally appeals to dynamic causal modelling neuroimaging data. When is at rest, however, this sort characterization been limited correlations (functional connectivity). In...
At a European Society of Neuroradiology (ESNR) Annual Meeting 2015 workshop, commonalities in practice, current controversies and technical hurdles glioma MRI were discussed. We aimed to formulate guidance on determine its feasibility, by seeking information imaging practices from the community. Invitations structured survey emailed ESNR members (n=1,662) associates (n=6,400), national radiologists’ societies distributed via social media. Responses received 220 institutions (59% academic)....
Background and Purpose — An increased frequency of clinically silent microbleeds (MB) has recently been observed in patients with sporadic small-vessel disease related to vascular amyloid deposition or hypertension. In this study, we searched for cerebral MBs autosomal dominant arteriopathy subcortical infarcts leukoencephalopathy (CADASIL), a unique type caused by mutations the Notch3 gene. Our purposes were (1) determine frequency, extent, pattern CADASIL; (2) analyze relationship between...
To localize the cortical motor hand area with functional magnetic resonance (MR) imaging and electrical stimulation at surgery to detect changes due central lesions.Fast-gradient-echo MR images of brain were acquired in four healthy volunteers six patients tumors region before, during, after repetitive opening closing hand. Open was performed, exposed cortex stimulated.At imaging, circumscribed signal intensity that correlated time task seen contralateral brain. In volunteers, change...
The recently completed European trial of interferon beta-1b (IFNβ-1b) in patients with secondary progressive multiple sclerosis (SP sclerosis) has given an opportunity to assess the impact treatment on cerebral atrophy using serial MRI. Unenhanced T1-weighted brain imaging was acquired a subgroup 95 from five centres; performed at 6-month intervals month 0 36. A blinded observer measured volume four contiguous 5 mm hemisphere slices each time point, algorithm high level reproducibility and...