A5108008488- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Health Systems, Economic Evaluations, Quality of Life
- Advanced Neuroimaging Techniques and Applications
- Neural dynamics and brain function
- Medical Imaging Techniques and Applications
- Cancer-related cognitive impairment studies
- Neurological Disease Mechanisms and Treatments
- Tryptophan and brain disorders
- Amyotrophic Lateral Sclerosis Research
- Advanced MRI Techniques and Applications
- Frailty in Older Adults
- Gut microbiota and health
- Radiomics and Machine Learning in Medical Imaging
- Neuroinflammation and Neurodegeneration Mechanisms
- Cerebrovascular and Carotid Artery Diseases
- Epigenetics and DNA Methylation
- Cholinesterase and Neurodegenerative Diseases
- Parkinson's Disease Mechanisms and Treatments
- Computational Drug Discovery Methods
- Bioinformatics and Genomic Networks
- Cerebrospinal fluid and hydrocephalus
- Health, Environment, Cognitive Aging
Centro San Giovanni di Dio Fatebenefratelli
2014-2025
University of Geneva
2014-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2009-2024
University Hospital of Geneva
2019-2024
University Hospital of Bern
2024
University Psychiatric Hospital
2024
Furtwangen University
2024
Amsterdam Neuroscience
2024
Vrije Universiteit Amsterdam
2024
IRCCS Istituto Auxologico Italiano
2024
Increasing evidence links the gut microbiota (GM) to Alzheimer's disease (AD) but mechanisms through which bacteria influence brain are still unclear. This study tests hypothesis that GM and mediators of microbiota-gut-brain axis (MGBA) associated with amyloid cascade in sporadic AD.
The key Alzheimer's disease (AD) biomarkers are traditionally measured with techniques/exams that either expensive (amyloid-positron emission tomography (PET) and tau-PET), invasive (cerebrospinal fluid Aβ42 p-tau181), or poorly specific (atrophy on MRI hypometabolism fluorodeoxyglucose-PET). Recently developed plasma could significantly enhance the efficiency of diagnostic pathway in memory clinics improve patient care. This study aimed to: (1) confirm correlations between traditional AD...
Abstract Background and objective Phosphorylated tau ( p -tau) 217 has recently received attention because it seems more reliable than other -tau variants for identifying Alzheimer’s disease (AD) pathology. Thus, we aimed to compare the diagnostic accuracy of plasma CSF -tau217 with -tau181 -tau231 in a memory clinic cohort. Methods The study included 114 participants (CU = 33; MCI 67; Dementia 14). were correlated versus continuous measures amyloid (A) (T)-PET. phospho-epitopes assessed...
Abstract Purpose As dual-phase amyloid-PET can evaluate amyloid (A) and neurodegeneration (N) with a single tracer injection, tau-PET might be able to provide both tau (T) N. Our study aims assess the association of early-phase scans 18 F-fluorodeoxyglucose (FDG) PET their comparability in discriminating Alzheimer’s disease (AD) patients differentiating neurodegenerative patterns. Methods 58 subjects evaluated at Geneva Memory Center underwent F-Flortaucipir-PET acquisition (eTAU) F-FDG-PET...
• We present Neuroharmony, a harmonization tool for images from unseen scanners. developed Neuroharmony using total of 15,026 sMRI images. The was able to reduce scanner-related bias scans. represents significant step towards imaging-based clinical tools. is available at https://github.com/garciadias/Neuroharmony .
Abstract Biomarker testing is recommended for the accurate and timely diagnosis of Alzheimer's disease (AD). Using illustrative case narratives we consider how cerebrospinal fluid (CSF) biomarker tests may be used in different presentations cognitive impairment to facilitate differential diagnosis, improving diagnostic accuracy, providing prognostic information, guiding personalized management diverse scenarios. Evidence shows that (1) CSF ratios are superior amyloid beta (Aβ)1‐42 alone; (2)...
Behavioral disturbances are core features of frontotemporal dementia (FTD); however, symptom progression across the course disease is not well characterized in genetic FTD.To investigate behavioral frequency and severity their evolution different forms FTD.This longitudinal cohort study, international Genetic FTD Initiative (GENFI), was conducted from January 30, 2012, to May 31, 2019, at 23 multicenter specialist tertiary research clinics United Kingdom, Netherlands, Belgium, France, Spain,...
Abstract Normative modelling is an emerging method for quantifying how individuals deviate from the healthy populational pattern. Several machine learning models have been implemented to develop normative investigate brain disorders, including regression, support vector machines and Gaussian process models. With advance of deep technology, use neural networks has also proposed. In this study, we assessed based on autoencoders using structural neuroimaging data patients with Alzheimer’s...
Abstract INTRODUCTION Tau and neurodegeneration strongly correlate with cognitive impairment, as compared to amyloid. However, their contribution in explaining cognition predicting decline memory clinics remains unclarified. METHODS We included 94 participants Mini‐Mental State Examination (MMSE), tau positron emission tomography (PET), amyloid PET, fluorodeoxyglucose (FDG) MRI scans from Geneva Memory Center. Linear regression mediation analyses tested the independent combined association...
Alzheimer’s disease (AD) is the most frequent neurodegenerative with an increasing prevalence in industrialized, aging populations. AD susceptibility has established genetic basis which been focus of a large number genome-wide association studies (GWAS) published over last decade. Most these GWAS used dichotomized clinical diagnostic status, i.e., case vs. control classification, as outcome phenotypes, without use biomarkers. An alternative and potentially more powerful study design afforded...
An accurate prognosis is especially pertinent in mild cognitive impairment (MCI), when individuals experience considerable uncertainty about future progression.
To support clinical trial designs focused on early interventions, our study determined reliable amyloid-β (Aβ) accumulation based Centiloids (CL) in pre-dementia populations. A total of 1032 participants from the Amyloid Imaging to Prevent Alzheimer's Disease-Prognostic and Natural History Study (AMYPAD-PNHS) Insight46 who underwent [18F]flutemetamol, [18F]florbetaben or [18F]florbetapir amyloid-PET were included. normative strategy was used define by estimating 95th percentile longitudinal...
: The guidelines on hypertension recently published by the European Societies of Hypertension and Cardiology, have acknowledged cognitive function (and its decline) as a hypertension-mediated organ damage. In fact, brain damage can be only in more than 30% hypertensive patients, evolving undetected for several years if not appropriately screened; long it cannot provide either corrective measures, nor adequate risk stratification patient.The medical community dealing with older patients...