Diana Duro
A5052318088- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Amyotrophic Lateral Sclerosis Research
- Neurological Disease Mechanisms and Treatments
- Spatial Neglect and Hemispheric Dysfunction
- Prion Diseases and Protein Misfolding
- Functional Brain Connectivity Studies
- Parkinson's Disease Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Genomics and Rare Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Health, Environment, Cognitive Aging
- Health Systems, Economic Evaluations, Quality of Life
- Genetics and Neurodevelopmental Disorders
- Neurobiology of Language and Bilingualism
- Neurological Disorders and Treatments
- Epilepsy research and treatment
- Memory and Neural Mechanisms
- Neurological disorders and treatments
- Psychosomatic Disorders and Their Treatments
- Mitochondrial Function and Pathology
- Cerebrospinal fluid and hydrocephalus
- Mental Health and Psychiatry
- Schizophrenia research and treatment
- Cholinesterase and Neurodegenerative Diseases
University of Coimbra
2013-2025
Hospitais da Universidade de Coimbra
2009-2023
KU Leuven
2022
University of Antwerp
2022
London School of Hygiene & Tropical Medicine
2019
King's College London
2019
National Institute of Health Dr. Ricardo Jorge
2013
Neurology, Inc
2012-2013
Oxidative stress has been shown to be a triggering event in the pathogenesis of Alzheimer's disease (AD). However, little evidence exists on role oxidative imbalance Mild Cognitive Impairment (MCI), group with high risk progression t
Cerebrospinal fluid (CSF) biomarkers have been used to increase the evidence of underlying Alzheimer's disease (AD) pathology in mild cognitive impairment (MCI). However, CSF biomarker-based classification often results conflicting profiles with controversial prognostic value. Normalization Aβ42 concentration level total amyloid beta (Aβ), using Aβ42/40 ratio, has shown improve distinction between AD and non-AD dementia. Therefore, we evaluated whether ratio would MCI categorization more...
Behavioral disturbances are core features of frontotemporal dementia (FTD); however, symptom progression across the course disease is not well characterized in genetic FTD.To investigate behavioral frequency and severity their evolution different forms FTD.This longitudinal cohort study, international Genetic FTD Initiative (GENFI), was conducted from January 30, 2012, to May 31, 2019, at 23 multicenter specialist tertiary research clinics United Kingdom, Netherlands, Belgium, France, Spain,...
The Montreal Cognitive Assessment (MoCA) is a brief instrument developed for the screening of milder forms cognitive impairment, having surpassed well-known limitations Mini-Mental State Examination (MMSE). aim present study was to validate MoCA as test behavioral-variant frontotemporal dementia (bv-FTD) by examining its psychometric properties and diagnostic accuracy. Three matched subgroups participants were considered: bv-FTD (n = 50), Alzheimer disease control group healthy adults 50)....
The Mini-Mental State Examination is the most commonly used cognitive screening test. In Portugal, cut-off scores are defined according to literacy groups, but different proposals have been recommended by more representative studies. We therefore propose confirm influence of demographical variables, such as age and education, in subjectâs performance; evaluating discriminant ability new normative data; further examine diagnostic acuity validated scoring for mild impairment prevalent types...
Abstract Introduction Mononuclear phagocytes play a critical role during Alzheimer's disease (AD) pathogenesis due to their contribution innate immune responses and amyloid beta (Aβ) clearance mechanisms. Methods Blood‐derived monocytes (BDMs) monocyte‐derived macrophages (MDMs) were isolated from blood of AD, mild cognitive impairment (MCI) patients, age‐matched healthy controls for molecular phenotypic comparisons. Results The chemokine/chemokine receptor CCL2/CCR2 axis was impaired in...
Studies have previously shown evidence for presymptomatic cortical atrophy in genetic FTD. Whilst initial investigations also identified early deep grey matter volume loss, little is known about the extent of subcortical involvement, particularly within subregions, and how this differs between groups. 480 mutation carriers from Genetic FTD Initiative (GENFI) were included (198 GRN, 202 C9orf72, 80 MAPT), together with 298 non-carrier cognitively normal controls. Cortical volumes interest...
Abstract Several CSF and blood biomarkers for genetic frontotemporal dementia have been proposed, including those reflecting neuroaxonal loss (neurofilament light chain phosphorylated neurofilament heavy chain), synapse dysfunction [neuronal pentraxin 2 (NPTX2)], astrogliosis (glial fibrillary acidic protein) complement activation (C1q, C3b). Determining the sequence in which become abnormal over course of disease could facilitate staging help identify mutation carriers with prodromal or...
Blood-based biomarkers are promising tools for the diagnosis of Alzheimer disease (AD) at prodromal stages (mild cognitive impairment [MCI]) and hoped to be implemented as screening patients with complaints. In this work, we evaluated potential peripheral neurological predict progression AD dementia relation between blood cerebrospinal fluid (CSF) markers in MCI referred from a general department.A group 106 followed Neurology Department Coimbra University Hospital was included. Data...
Recent studies show that most of the oxidative changes found in Alzheimer's disease (AD) are already present mild cognitive impairment (MCI) patients. The question arises as to whether stress has a role progression MCI AD. We conducted longitudinal study on 70 patients, and peripheral blood levels broad spectrum non-enzymatic enzymatic antioxidant defenses, well lipid protein oxidation markers nitrogen species were determined. At baseline, there no differences any indexes damage between...
Memory impairment is often present in frontotemporal dementia (FTD) as a result of an inefficient use learning strategies, sometimes leading to misdiagnosis Alzheimer's disease (AD). The Free and Cued Selective Reminding Test (FCSRT) memory test that controls attention acquisition, by providing category cues the process. main goal this study was show usefulness FCSRT distinction between behavioral (bv-) FTD AD. Three matched subgroups participants were considered: bv-FTD (n = 32), AD control...
Despite having the same histopathological characteristics, early-onset and late-onset Alzheimer's disease (AD) patients show some distinct clinical neuropsychological profiles. Early Onset Mild Cognitive Impairment (EOMCI) is a less characterized group. The aim of this study to characterize MCI probably due AD in terms clinical, genetic, Cerebrospinal fluid (CSF) biomarkers profile conversion rate EOMCI, compared form (LOMCI).
The presymptomatic phase of neurodegenerative diseases are characterized by structural brain changes without significant clinical features. We set out to investigate the contribution functional network resilience preserved cognition in genetic frontotemporal dementia. studied 172 people from families carrying abnormalities C9orf72, MAPT, or PGRN. Networks were extracted MRI data and assessed using graph theoretical analysis. found that despite loss both volume connections, there is...
Abstract Background Neuroinflammation is emerging as an important pathological process in frontotemporal dementia (FTD), but biomarkers are lacking. We aimed to determine the value of complement proteins, which key components innate immunity, cerebrospinal fluid (CSF) and plasma presymptomatic symptomatic genetic FTD mutation carriers. Methods measured proteins C1q C3b CSF by ELISAs 224 GRN, C9orf72 or MAPT carriers non-carriers participating Genetic Frontotemporal Dementia Initiative...
Abstract Primary progressive aphasia is most commonly a sporadic disorder, but in some cases, it can be genetic. This study aimed to understand the clinical, cognitive and imaging phenotype of genetic forms primary comparison canonical nonfluent, semantic logopenic subtypes seen disease. Participants with were recruited from international multicentre GENetic Frontotemporal dementia Initiative compared healthy controls as well cohort people aphasia. Symptoms assessed using language,...
The Clock Drawing Test has been systematically used to assess visuospatial deficits related the parietal lobes, but we now acknowledge its much more complex relation with other cognitive abilities. Despite common use in clinical and investigational practices, no study developed normative data for Portuguese population. We present distribution of clock drawing scores using three scoring systems a representative community sample cognitively healthy subjects. found that were well correlated...
The previously described and validated Erlangen Score (ES) algorithm enables interpretation of the cerebrospinal fluid (CSF) biomarkers Alzheimer's disease (AD), ordering them on an ordinal scale: from neurochemically normal (ES = 0) through improbable AD 1), possible 2 or 3), to probable 4). Here we assess accuracy ES in predicting hazards progression mild cognitive impairment (MCI) stage dementia (Alzheimer's (ADD)) a novel, single-center cohort. Baseline CSF (amyloid beta (Aβ) 1–42,...
A detailed understanding of the pathological processes involved in genetic frontotemporal dementia is critical order to provide patients with an optimal future treatment. Protein levels CSF have potential reflect different pathophysiological brain. We aimed identify and evaluate panels proteins separate symptomatic individuals from without clinical symptoms (unaffected), as well presymptomatic mutation non-carriers.A multiplexed antibody-based suspension bead array was used analyse 111...
Objective: The Alzheimer's disease assessment scale–Cognitive Subscale (ADAS-Cog) is a battery to assess cognitive performance in (AD) and was developed according the core characteristics of decline AD: memory, language, praxis, constructive ability, orientation. aim this study explore diagnostic accuracy discriminative capacity ADAS-Cog for Mild Cognitive Impairment (MCI) AD, using cut-off points Portuguese population. Method: European version administrated 650 participants, divided into...