A5020619868- Advanced Neuroimaging Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Neurological disorders and treatments
- Amyotrophic Lateral Sclerosis Research
- Genetic Neurodegenerative Diseases
- Alzheimer's disease research and treatments
- Advanced MRI Techniques and Applications
- Dementia and Cognitive Impairment Research
- Multiple Sclerosis Research Studies
- Neurogenetic and Muscular Disorders Research
- Neurobiology of Language and Bilingualism
- Cerebral Palsy and Movement Disorders
- Neurological diseases and metabolism
- Botulinum Toxin and Related Neurological Disorders
- EEG and Brain-Computer Interfaces
- Transcranial Magnetic Stimulation Studies
- Balance, Gait, and Falls Prevention
- Health, Environment, Cognitive Aging
- Muscle activation and electromyography studies
- Prion Diseases and Protein Misfolding
- RNA regulation and disease
- Neurological Disease Mechanisms and Treatments
- Peripheral Neuropathies and Disorders
- Long-Term Effects of COVID-19
Vita-Salute San Raffaele University
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2009-2025
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2009-2025
IRCCS Ospedale San Raffaele
2009-2025
Scuola Superiore Sant'Anna
2025
San Raffaele University of Rome
2011-2024
Cognitive Neuroimaging Lab
2011-2024
Neuroscience Institute
2012-2024
University of Genoa
2024
Fondazione IRCCS Istituto Neurologico Carlo Besta
2023
We built and validated a deep learning algorithm predicting the individual diagnosis of Alzheimer's disease (AD) mild cognitive impairment who will convert to AD (c-MCI) based on single cross-sectional brain structural MRI scan. Convolutional neural networks (CNNs) were applied 3D T1-weighted images from ADNI subjects recruited at our Institute (407 healthy controls [HC], 418 AD, 280 c-MCI, 533 stable MCI [s-MCI]). CNN performance was tested in distinguishing c-MCI s-MCI. High levels...
Neuropsychological deficits in patients with multiple sclerosis (MS) have been shown to be associated the major pathological substrates of disease, ie, inflammatory demyelination and neurodegeneration. Double inversion recovery sequences allow cortical lesions (CLs) detected brain MS. Modern postprocessing techniques atrophy assessed reliably.To investigate contribution gray matter tissue loss cognitive impairment relapsing-remitting MS.Cross-sectional survey.Referral, hospital-based MS...
To assess cortical gray matter (GM) changes in MS and establish their relevance to clinical disability inflammatory of white (WM) patients with the relapsing-remitting (RR) primary progressive (PP) forms disease.Conventional MRI examinations were obtained definite who had either RR or PP form disease. An automated analysis tool was used conventional T1-weighted MR images obtain total brain volumes normalized for head size. Total lesion load estimated on proton density T2-weighted images. The...
In March 2020, the World Health Organization declared a global pandemic due to novel coronavirus SARS-CoV-2 and several governments planned national quarantine in order control virus spread. Acute psychological effects of frail elderly subjects with special needs, such as patients dementia, have been poorly investigated. The aim this study was assess modifications neuropsychiatric symptoms during dementia their caregivers.This is sub-study multicenter nation-wide survey. A structured...
To characterize in vivo signatures of pathological diagnosis a large cohort patients with primary progressive aphasia (PPA) variants defined by current diagnostic classification.Extensive clinical, cognitive, neuroimaging, and neuropathological data were collected from 69 sporadic PPA, divided into 29 semantic (svPPA), 25 nonfluent (nfvPPA), 11 logopenic (lvPPA), 4 mixed PPA. Patterns gray matter (GM) white (WM) atrophy at presentation assessed tested as predictors using support vector...
<h3>Objective</h3> To determine whether brain atrophy and lesion volumes predict subsequent 10 year clinical evolution in multiple sclerosis (MS). <h3>Design</h3> From eight MAGNIMS (MAGNetic resonance Imaging MS) centres, we retrospectively included 261 MS patients with MR imaging at baseline after 1–2 years, Expanded Disability Status Scale (EDSS) scoring years. Annualised whole atrophy, central rates T2 were calculated. Patients categorised by diagnosis as primary progressive (n=77),...
Primary progressive aphasia is a clinical syndrome that encompasses three major phenotypes: non-fluent/agrammatic, semantic and logopenic. These entities have been associated with characteristic patterns of focal grey matter atrophy in left posterior frontoinsular, anterior temporal temporoparietal regions, respectively. Recently, network-level dysfunction has hypothesized but research to date focused largely on studying damage. The aim this study was assess the integrity white tracts...
To explore the regional patterns of white matter (WM) tract damage in (a) patients with probable Alzheimer disease (AD) and (b) amnestic mild cognitive impairment (aMCI) at least one abnormal biomarker to investigate whether WM is related gray (GM) atrophy.This study was approved by institutional review board, written informed consent obtained from each participant. Twenty-three AD, 15 aMCI, healthy control subjects underwent diffusion tensor magnetic resonance imaging. investigated using...
<h3>Background:</h3> Different double inversion recovery (DIR) sequences are currently used in multiple sclerosis (MS) research centers to visualize cortical lesions, making it difficult compare published data. This study aimed formulate consensus recommendations for scoring lesions patients with MS, using DIR images acquired 6 European according local protocols. <h3>Methods:</h3> Consensus were formulated and tested a multinational meeting. <h3>Results:</h3> Cortical defined as focal...
Brain-computer interfaces (BCIs) have the potential to improve functionality in chronic stoke patients when applied over a large number of sessions. Here we evaluated effect and underlying mechanisms three BCI training sessions double-blind sham-controlled design. The is based on Hebbian principles associativity that hypothesize neural assemblies activated correlated manner will strengthen synaptic connections. Twenty-two stroke were divided into two groups. Movement-related cortical...
Recommendations for using fluorodeoxyglucose positron emission tomography (FDG-PET) to support the diagnosis of dementing neurodegenerative disorders are sparse and poorly structured.Twenty-one questions on diagnostic issues semi-automated analysis assist visual reading were defined. Literature was reviewed assess study design, risk bias, inconsistency, imprecision, indirectness effect size. Critical outcomes sensitivity, specificity, accuracy, positive/negative predictive value, area under...
Previous studies showed that quarantine for pandemic diseases is associated with several psychological and medical effects. The consequences of COVID-19 in patients dementia are unknown. We investigated the clinical changes Alzheimer's disease other dementias, evaluated caregivers' distress during quarantine.
Cognitive deficits in semantic dementia have been attributed to anterior temporal lobe grey matter damage; however, key aspects of the syndrome could be due altered anatomical connectivity between language pathways involving lobe. The aim this study was investigate left language-related cerebral using diffusion tensor imaging-based tractography and combine findings with cortical functional magnetic resonance imaging data obtained during a reading activation task. inferior longitudinal...
The left posterior inferior frontal cortex (IFC) is important for syntactic processing, and has been shown in many functional imaging studies to be differentially recruited the processing of syntactically complex sentences relative simpler ones. In nonfluent variant primary progressive aphasia (PPA), degeneration IFC associated with expressive receptive agrammatism; however, status this region PPA not well understood. Our objective was determine whether atrophic PPA. Using structural...
Apolipoprotein ε4 (apoE4) has been strongly linked with Alzheimer's disease (AD) and contributes to several other neurological disorders. We investigated the influence of allele carrier status on pattern gray matter atrophy severity in 51 patients probable AD 31 behavioral variant frontotemporal dementia (bvFTD), compared 56 healthy controls. Voxel-based morphometry was performed by using statistical parametric mapping. The frequency higher group ( P < 0.001) than controls but not bvFTD...
Semantic dementia (SD) is a neurodegenerative disease characterized by atrophy of anterior temporal regions and progressive loss semantic memory. SD patients often present with surface dyslexia, relatively selective impairment in reading low-frequency words exceptional or atypical spelling-to-sound correspondences. Exception are typically 'over-regularized' pronounced as they spelled (e.g. 'sew' 'sue'). This suggests that the absence sufficient item-specific knowledge, exception read relying...