A5020412206- Amyotrophic Lateral Sclerosis Research
- Parkinson's Disease Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Neurogenetic and Muscular Disorders Research
- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Neurobiology of Language and Bilingualism
- Neurological disorders and treatments
- Cerebral Palsy and Movement Disorders
- Advanced MRI Techniques and Applications
- Health, Environment, Cognitive Aging
- Genetic Neurodegenerative Diseases
- RNA regulation and disease
- Neurological diseases and metabolism
- Cerebrovascular and genetic disorders
- S100 Proteins and Annexins
- Neurological Disease Mechanisms and Treatments
- Prion Diseases and Protein Misfolding
- Language Development and Disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Neural dynamics and brain function
- Multiple Sclerosis Research Studies
- Acute Ischemic Stroke Management
- EEG and Brain-Computer Interfaces
Vita-Salute San Raffaele University
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2025
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2019-2025
IRCCS Ospedale San Raffaele
2021-2025
Neuroscience Institute
2014-2024
Cognitive Neuroimaging Lab
2021-2024
San Raffaele University of Rome
2015-2023
IRCCS Istituto Auxologico Italiano
2021
University of Campania "Luigi Vanvitelli"
2020
University of Turin
2020
To characterize in vivo signatures of pathological diagnosis a large cohort patients with primary progressive aphasia (PPA) variants defined by current diagnostic classification.Extensive clinical, cognitive, neuroimaging, and neuropathological data were collected from 69 sporadic PPA, divided into 29 semantic (svPPA), 25 nonfluent (nfvPPA), 11 logopenic (lvPPA), 4 mixed PPA. Patterns gray matter (GM) white (WM) atrophy at presentation assessed tested as predictors using support vector...
We have described cerebrospinal fluid (CSF) myeloid microvesicles (MVs) as a marker of microglia activation during neuroinflammation in Alzheimer disease (AD), and characterized their ability to produce toxic amyloid β1-42 (Aβ1-42 ) oligomers from aggregated or soluble substrate. The aim this study is investigate the association CSF MVs with neuroimaging, clinical, paraclinical data AD mild cognitive impairment (MCI).We collected 106 patients, 51 MCI 29 neurologically healthy controls....
Abstract Objective To assess the structural correlates of cognitive and behavioral impairment in motor neuron diseases (MND) using multimodal MRI. Methods One hundred one patients with sporadic MND (56 classic amyotrophic lateral sclerosis, 31 upper phenotype, 14 lower phenotype) 51 controls were enrolled. Patients classified into a pure syndrome (MND‐motor) cognitive/behavioral symptoms (MND‐plus). Cortical thickness measures diffusion tensor (DT) metrics white matter (WM) tracts assessed....
The ability to predict the pathology underlying different neurodegenerative syndromes is of critical importance owing advent molecule-specific therapies.To determine rates positron emission tomography (PET) amyloid positivity in main clinical variants primary progressive aphasia (PPA).This prospective clinical-pathologic case series was conducted at a tertiary research clinic specialized cognitive disorders. Patients were evaluated as part prospective, longitudinal study between January 2002...
<h3>Objective</h3> To investigate structural and functional neural organization in amyotrophic lateral sclerosis (ALS), primary (PLS), progressive muscular atrophy (PMA). <h3>Methods</h3> A total of 173 patients with sporadic ALS, 38 PLS, 28 PMA, 79 healthy controls were recruited from 3 Italian centers. Participants underwent clinical, neuropsychological, brain MRI evaluations. Using graph analysis connectomics, global lobar topologic network properties regional connectivity assessed. The...
This prospective study developed an MRI-based method for identification of individual motor neuron disease (MND) patients and test its accuracy at the patient level in independent sample compared with mimic disorders. 123 amyotrophic lateral sclerosis (ALS), 44 predominantly upper (PUMN), 20 ALS-mimic disorders, 78 healthy controls were studied. The diagnostic precentral cortical thickness diffusion tensor (DT) MRI metrics corticospinal callosal tracts assessed a training cohort externally...
To understand whether the clinical phenotype of nonfluent/agrammatic primary progressive aphasia (nfvPPA) could present differences depending on patient's native language.In this cross-sectional study, we analyzed connected speech samples in monolingual English (nfvPPA-E) and Italian speakers (nfvPPA-I) who were diagnosed with nfvPPA matched for age, sex, Mini-Mental State Examination scores. Patients also received a comprehensive neuropsychological battery. All patients 2 groups age-matched...
<h3>Background and Objectives</h3> A significant overlap between amyotrophic lateral sclerosis (ALS) behavioral variant of frontotemporal dementia (bvFTD) has been observed at clinical, genetic, pathologic levels. Within this continuum presentations, the presence mild cognitive or symptoms in patients with ALS consistently reported, although it is unclear whether to be considered a distinct phenotype rather natural evolution ALS. Here, we used mathematical modeling MRI connectomic data...
Multifactorial models integrating brain variables at multiple scales are warranted to investigate aging and its relationship with neurodegeneration. Our aim was evaluate how affects functional connectivity of pivotal regions the human connectome (i.e., hubs), which represent potential vulnerability 'stations' aging, whether such effects influence structural changes whole brain. We combined information vulnerability, studied through an innovative graph-analysis approach (stepwise...
The criteria for assessing upper motor neuron pathology in pure lower disease (LMND) still remain a major issue of debate with respect to the clinical classification as an amyotrophic lateral sclerosis (ALS) variant. study was designed investigate white matter damage by hypothesis-guided tract-of-interest-based approach patients LMND compared healthy controls and ´classical´ ALS order identify vivo brain structural changes according neuropathologically defined affectation pattern. Data were...
ABSTRACT Background White matter hyperintensities (WMHs) have a role in cognitive impairment normal brain aging, while the effect on Parkinson's disease (PD) progression is still controversial. Objective To investigate longitudinal evolution of micro‐ and macrostructural damage cerebral white (WM) its relationship with clinical picture PD. Methods A total 154 PD patients underwent clinical, cognitive, magnetic resonance imaging (MRI) assessment once year for up to 4 years. Sixty healthy...
Semantic behavioral variant frontotemporal dementia (sbvFTD) is a neurodegenerative condition presenting with specific and semantic derangements predominant atrophy of the right anterior temporal lobe (ATL). The objective was to evaluate clinical, neuropsychological, neuroimaging, genetic features an Italian sbvFTD cohort, defined according recently proposed guidelines, compared primary progressive aphasia (svPPA) FTD (bvFTD) patients.
Diagnosing the different variants of primary progressive aphasia (PPA) is challenging, but more accurate characterization can improve patient management and treatment outcomes. This study aimed to identify following: (1) which speech features, alone or combined with language assessment gray matter volumes (GMVs), best distinguish PPA (2) how connected evolves in PPA. prospective was conducted at IRCCS San Raffaele Hospital Milan, Italy, between 2010 2021. We included patients who underwent...