A5080720361- Neurological disorders and treatments
- Functional Brain Connectivity Studies
- Parkinson's Disease Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Genetic Neurodegenerative Diseases
- Amyotrophic Lateral Sclerosis Research
- Advanced MRI Techniques and Applications
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Health, Environment, Cognitive Aging
- Cerebral Palsy and Movement Disorders
- EEG and Brain-Computer Interfaces
- Botulinum Toxin and Related Neurological Disorders
- Balance, Gait, and Falls Prevention
- Trigeminal Neuralgia and Treatments
- Neurobiology of Language and Bilingualism
- Neurological diseases and metabolism
- Mental Health Research Topics
- Neural dynamics and brain function
- Neurogenetic and Muscular Disorders Research
- Ginkgo biloba and Cashew Applications
- Lysosomal Storage Disorders Research
- Neurosurgical Procedures and Complications
- Psychosomatic Disorders and Their Treatments
- Meningioma and schwannoma management
Vita-Salute San Raffaele University
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2025
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2020-2025
Cognitive Neuroimaging Lab
2021-2025
University of Genoa
2024
San Raffaele University of Rome
2016-2023
IRCCS Ospedale San Raffaele
2021-2023
Gordon Center for Medical Imaging
2019-2022
Harvard University
2019-2022
Massachusetts General Hospital
2019-2022
We built and validated a deep learning algorithm predicting the individual diagnosis of Alzheimer's disease (AD) mild cognitive impairment who will convert to AD (c-MCI) based on single cross-sectional brain structural MRI scan. Convolutional neural networks (CNNs) were applied 3D T1-weighted images from ADNI subjects recruited at our Institute (407 healthy controls [HC], 418 AD, 280 c-MCI, 533 stable MCI [s-MCI]). CNN performance was tested in distinguishing c-MCI s-MCI. High levels...
Abstract Objective To use a multimodal approach to assess brain structural pathways and resting state (RS) functional connectivity abnormalities in patients with Parkinson's disease freezing of gait (PD‐FoG). Methods T1‐weighted, diffusion tensor (DT) MRI RS (fMRI) were obtained from 22 PD‐FoG 35 controls on 3.0 T MR scanner. Patients underwent clinical, motor, neuropsychological evaluations. Gray matter (GM) volumes white (WM) damage assessed using voxel based morphometry tract‐based...
To investigate functional brain network architecture in early-onset Alzheimer disease (EOAD) and behavioral variant frontotemporal dementia (bvFTD).Thirty-eight patients with bvFTD, 37 EOAD, 32 age-matched healthy controls underwent 3D T1-weighted resting-state fMRI. Graph analysis connectomics assessed global local topologic properties, regional connectivity, intrahemispheric interhemispheric between-lobe connectivity.Despite similarly extensive cognitive impairment relative to controls,...
ABSTRACT Background Action observation training and motor imagery may improve learning in Parkinson's disease (PD). Objectives The objectives of this study were to assess mobility balance (performing dual tasks) brain functional reorganization following 6 weeks action associated with dual‐task gait/balance exercises PD patients postural instability gait disorders relative alone. Methods Twenty‐five PD–postural disorder randomized into 2 groups: the DUAL‐TASK+AOT‐MI group performed a 6‐week...
Purpose To investigate the structural brain connectome in patients with Parkinson disease (PD) and mild cognitive impairment (MCI) PD without MCI. Materials Methods This prospective study was approved by local ethics committees, written informed consent obtained from all subjects prior to enrollment. The individual of 170 (54 MCI, 116 MCI) 41 healthy control using deterministic diffusion-tensor tractography. A network-based statistic used assess connectivity differences among groups. Results...
Clinical manifestations and evolution are very heterogeneous among individuals with Parkinson's disease (PD). The aims of this study were to investigate the pattern progressive brain atrophy in PD according stage elucidate what extent cortical thinning subcortical related clinical motor non-motor evolution. 154 patients at different stages assessed over time using motor, structural MRI evaluations for a maximum 4 years. Cluster analysis defined subtypes. Cortical baseline relative 60 healthy...
Abstract Background The objectives of this study were to investigate progressive cortical thinning and volume loss in Parkinson's disease (PD) patients with different longitudinal patterns cognitive decline: stable normal cognition, mild impairment, conversion dementia. Methods We recruited 112 (37 20 36 19 dementia) 38 healthy controls. All underwent at least 2 visits within 4 years including clinical/cognitive assessments structural MRI (total visits, 393). Baseline thickness gray matter...
<h3>Objective</h3> To investigate structural and functional neural organization in amyotrophic lateral sclerosis (ALS), primary (PLS), progressive muscular atrophy (PMA). <h3>Methods</h3> A total of 173 patients with sporadic ALS, 38 PLS, 28 PMA, 79 healthy controls were recruited from 3 Italian centers. Participants underwent clinical, neuropsychological, brain MRI evaluations. Using graph analysis connectomics, global lobar topologic network properties regional connectivity assessed. The...
We evaluated the value of resting-state EEG source biomarkers to characterize mild cognitive impairment (MCI) subjects with an Alzheimer's disease (AD)-like cerebrospinal fluid (CSF) profile and track neurodegeneration throughout AD continuum. further applied a functional MRI (fMRI)-driven model reconstruction tested its advantage in terms diagnostic accuracy.Thirty-nine consecutive patients dementia (ADD), 86 amnestic MCI, 33 healthy enter study. All ADD subjects, 37 out MCI distinct group...
ABSTRACT Background Functional brain connectivity alterations may be detectable even before the occurrence of atrophy, indicating their potential as early markers pathological processes. Objective We aimed to determine whole‐brain network topologic organization functional connectome in a large cohort drug‐naïve Parkinson's disease (PD) patients using resting‐state magnetic resonance imaging and explore whether baseline changes predict clinical progression. Methods One hundred forty‐seven...
<h3>Background and Objectives</h3> A significant overlap between amyotrophic lateral sclerosis (ALS) behavioral variant of frontotemporal dementia (bvFTD) has been observed at clinical, genetic, pathologic levels. Within this continuum presentations, the presence mild cognitive or symptoms in patients with ALS consistently reported, although it is unclear whether to be considered a distinct phenotype rather natural evolution ALS. Here, we used mathematical modeling MRI connectomic data...
Abstract Parkinson’s disease (PD) patients can be classified in tremor-dominant (TD) and postural-instability-and-gait-disorder (PIGD) motor subtypes. PIGD represents a more aggressive form of the that TD have potentiality converting into. This study investigated functional alterations within cerebro-cerebellar system PD-TD PD-PIGD using stepwise connectivity (SFC) analysis identified neuroimaging features predict to conversion. Thirty-two PD-TD, 26 60 healthy controls performed...
Multifactorial models integrating brain variables at multiple scales are warranted to investigate aging and its relationship with neurodegeneration. Our aim was evaluate how affects functional connectivity of pivotal regions the human connectome (i.e., hubs), which represent potential vulnerability 'stations' aging, whether such effects influence structural changes whole brain. We combined information vulnerability, studied through an innovative graph-analysis approach (stepwise...
<h3>Background</h3> <i>TANK-binding kinase 1</i> (<i>TBK1</i>) gene has been recently identified as a causative of amyotrophic lateral sclerosis (ALS). <h3>Methods</h3> We sequenced the <i>TBK1</i> in cohort 154 Italian patients with ALS unclear genetic aetiology. subsequently assessed pathogenic potential novel variants using functional vitro studies: expression, targeting and activity were evaluated patient-derived fibroblasts cells transfected mutated-<i>TBK1</i> plasmids....
ABSTRACT Background White matter hyperintensities (WMHs) have a role in cognitive impairment normal brain aging, while the effect on Parkinson's disease (PD) progression is still controversial. Objective To investigate longitudinal evolution of micro‐ and macrostructural damage cerebral white (WM) its relationship with clinical picture PD. Methods A total 154 PD patients underwent clinical, cognitive, magnetic resonance imaging (MRI) assessment once year for up to 4 years. Sixty healthy...
Semantic behavioral variant frontotemporal dementia (sbvFTD) is a neurodegenerative condition presenting with specific and semantic derangements predominant atrophy of the right anterior temporal lobe (ATL). The objective was to evaluate clinical, neuropsychological, neuroimaging, genetic features an Italian sbvFTD cohort, defined according recently proposed guidelines, compared primary progressive aphasia (svPPA) FTD (bvFTD) patients.