A5069917604- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Functional Brain Connectivity Studies
- Cerebral Palsy and Movement Disorders
- Botulinum Toxin and Related Neurological Disorders
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Balance, Gait, and Falls Prevention
- Transcranial Magnetic Stimulation Studies
- Ginkgo biloba and Cashew Applications
- Spatial Neglect and Hemispheric Dysfunction
- Muscle activation and electromyography studies
- Lysosomal Storage Disorders Research
- Cardiac Health and Mental Health
- Stroke Rehabilitation and Recovery
- Cardiovascular Health and Risk Factors
- Psychosomatic Disorders and Their Treatments
- Blood Pressure and Hypertension Studies
- Diet and metabolism studies
- EEG and Brain-Computer Interfaces
- Hip and Femur Fractures
- Nuclear Receptors and Signaling
- Frailty in Older Adults
- Action Observation and Synchronization
University of Campania "Luigi Vanvitelli"
2022-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2023
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2019-2023
Vita-Salute San Raffaele University
2018-2022
Cognitive Neuroimaging Lab
2021
Neuroscience Institute
2020
San Raffaele University of Rome
2018
ABSTRACT Background Action observation training and motor imagery may improve learning in Parkinson's disease (PD). Objectives The objectives of this study were to assess mobility balance (performing dual tasks) brain functional reorganization following 6 weeks action associated with dual‐task gait/balance exercises PD patients postural instability gait disorders relative alone. Methods Twenty‐five PD–postural disorder randomized into 2 groups: the DUAL‐TASK+AOT‐MI group performed a 6‐week...
Clinical manifestations and evolution are very heterogeneous among individuals with Parkinson's disease (PD). The aims of this study were to investigate the pattern progressive brain atrophy in PD according stage elucidate what extent cortical thinning subcortical related clinical motor non-motor evolution. 154 patients at different stages assessed over time using motor, structural MRI evaluations for a maximum 4 years. Cluster analysis defined subtypes. Cortical baseline relative 60 healthy...
Hip fracture is the most common cause of hospitalization in frail geriatric subjects due to osteoporosis and recurrent falls. The clinical practice guidelines for rehabilitation after surgery patients with hip fractures recommend start treatment early. However, outbreak SARS-CoV-2 pandemic between December 2019 January 2020 forced lockdown. Thus, telerehabilitation seemed best solution remote assistance. In this scenario, aim our study assess effects clarify rearrange knowledge about its...
Emotional processes might influence freezing of gait (FoG) in Parkinson's disease (PD) patients. We assessed brain functional MRI (fMRI) activity during a "FoG-observation-task" PD-FoG patients relative to healthy controls. Twenty-four and 18 age- sex-matched controls performed clinical neuropsychological evaluations, fMRI experiments including: i) consisting watching patient experiencing FoG walking task (usually evoking FoG); ii) "gait-observation-task" subject performing similar tasks...
Abstract Previous studies suggested that brain regions subtending affective‐cognitive processes can be implicated in the pathophysiology of functional dystonia (FD). In this study, role network was explored two phenotypes FD: fixed (FixFD) and mobile (MobFD). We hypothesized each these would show peculiar connectivity (FC) alterations line with their divergent disease clinical expressions. Resting state fMRI (RS‐fMRI) obtained 40 FD patients (12 FixFD; 28 MobFD) 43 controls (14 young...
Abstract This study investigated longitudinal clinical, structural and functional brain alterations in Parkinson’s disease patients with freezing of gait (PD-FoG) those developing (PD-FoG-converters) not FoG (PD-non-converters) over two years. Moreover, this explored if any clinical and/or MRI metric predicts development. Thirty PD-FoG, 11 PD-FoG-converters PD-non-converters were followed for healthy controls included at baseline. Participants underwent visits. Cortical thickness, basal...
In this study, we aimed at investigating the possible association of urinary symptoms with whole-brain MRI resting-state functional connectivity (FC) alterations from distinct striatal subregions in a large cohort early PD patients.
May 9, 2019April 2019Free AccessClinical and fMRI Effects of Action Observation Motor Imagery Training on Dual-Task Performances in Parkinson’s Disease Patients With Postural Instability Gait Disorders (P5.6-010)Elisabetta Sarasso, Federica Agosta, Matteo Chiesi, Noemi Piramide, Elisa Canu, Ilaria Ravani, Sebastiano Galantucci, Andrea Tettamanti, Maria A. Volonté, Massimo FilippiAuthors Info & AffiliationsApril 2019 issue92 (15_supplement) Letters to the Editor
Abstract Background Glucocerebrosidase gene (GBA) mutations are the greatest genetic cause of Parkinson’s disease (PD). The aim this study was to monitor longitudinal course PD patients with GBA mutation (GBA‐positive) at diagnosis compared noncarriers (GBA‐negative) along a 5‐year follow‐up, evaluating changes in clinical and cognitive outcomes, cortical thickness, subcortical volumes. Method 10 GBA‐positive 20 GBA‐negative underwent clinical, neuropsychological brain MRI assessments entry...
Sunday, April 26April 14, 2020Free AccessBrain Functional Plasticity of the Limbic Circuit in Parkinson’s Disease Patients with Freezing Gait (3922)Elisabetta Sarasso, Federica Agosta, Noemi Piramide, Elisa Canu, Maria Antonietta Volonté, and Massimo FilippiAuthors Info & AffiliationsApril 2020 issue94 (15_supplement)https://doi.org/10.1212/WNL.94.15_supplement.3922 Letters to Editor