A5079630519- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Botulinum Toxin and Related Neurological Disorders
- Lysosomal Storage Disorders Research
- Trace Elements in Health
- Neurological diseases and metabolism
- Heavy Metal Exposure and Toxicity
- Advanced Neuroimaging Techniques and Applications
- Metabolism and Genetic Disorders
- Cellular transport and secretion
- Aluminum toxicity and tolerance in plants and animals
- Alzheimer's disease research and treatments
- Hereditary Neurological Disorders
- Glycogen Storage Diseases and Myoclonus
- Porphyrin Metabolism and Disorders
- Balance, Gait, and Falls Prevention
- Nuclear Receptors and Signaling
- Advanced MRI Techniques and Applications
- Epilepsy research and treatment
- Carbohydrate Chemistry and Synthesis
- Transcranial Magnetic Stimulation Studies
- Voice and Speech Disorders
- Muscle activation and electromyography studies
- Child Nutrition and Feeding Issues
University of Belgrade
2015-2025
Centar za Promociju Nauke
2012-2025
Univerzitetski Klinički Centar Srbije
2013-2024
John Wiley & Sons (United States)
2018-2020
University College London
2019
Status dystonicus (SD) is a rare, life-threatening disorder characterized by acute worsening of generalized dystonia.This study was conducted to characterize the pathogenesis, clinical course, and prognosis SD. We reviewed records six centers analyzed them together with all cases previously reported in literature.Eighty-nine episodes occurring 68 patients were studied. The majority males (64.7%), <15 years age (58.8%), had secondary dystonia as underlying condition (37.8%). mainly tonic...
ABSTRACT Background The neural basis of task specificity in dystonia is still poorly understood. This study investigated gray and white matter (WM) brain alterations patients with task‐specific (TSD) non‐task‐specific (NTSD). Methods Thirty‐six TSD (spasmodic dysphonia, writer's cramp), 61 NTSD (blepharospasm, cervical dystonia), 83 healthy controls underwent 3D T1‐weighted diffusion tensor magnetic resonance imaging (MRI). Whole cortical thickness voxel‐based morphometry; volumes basal...
Background and purpose To screen for glucocerebrosidase ( GBA ) mutations in a Serbian Parkinson's disease (PD) population. Methods Glucocerebrosidase exons 8–11 harbouring the most common were sequenced 360 patients with PD 348 controls from Serbia. Haplotype analysis was performed N370S mutation compared German Ashkenazi Jewish carriers. Results significantly more frequent (21/360; 5.8%) vs. (5/348; 1.4%; OR = 4.25; CI, 1.58–11.40; P 0.0041). Two carried homozygous or compound heterozygous...
Background and purpose: To investigate survival rates, prognostic factors, causes of death in Wilson disease (WD). Methods: In the years 1980–2007, a cohort 142 patients with WD was prospectively registered (54 presented neurologic symptoms, 49 hepatic 33 had mixed form, data were missing for six patients). The duration follow-up alive 11.1 ± 8.8 years. Results: After initiation treatment (d-penicillamine zinc salts), 79% stable or improved course disease. Despite early diagnosis appropriate...
The gait disturbances in Parkinson's disease (PD) patients occur occasionally and intermittently, appearing a random, inexplicable manner. These include festinations, shuffling, complete freezing of (FOG). Alternation walking pattern decreases the quality life may result falls. In order to recognize during PD patients, we recorded kinematics with wireless inertial measurement system designed an algorithm for automatic recognition classification patterns. combines perceptron neural network...
ABSTRACT Glucocerebrosidase gene mutations represent a genetic risk factor for the development of Parkinson's disease. This study investigated brain alterations in disease patients carrying heterozygous glucocerebrosidase using structural and diffusion tensor magnetic resonance imaging. Among 360 screened mutations, 19 mutation carriers (5.3%) were identified. Of these, 15 underwent neuropsychological evaluation imaging scan. Sixteen age‐ sex‐matched healthy controls 14 idiopathic without...
Abstract Health‐related quality of life (HRQoL) in Wilson's disease (WD) has not been extensively studied. Therefore, the purpose this cross‐sectional study was to identify clinical and demographic factors influencing HRQoL 60 treated, clinically stable patients with WD using a generic questionnaire, Medical Outcomes Study Short‐Form 36‐Item Health Survey (SF‐36). The level disability grading multisystemic manifestations were assessed by Global Assessment Scale for (GAS WD). Mini Mental...
Wilson's disease (WD) is an autosomal-recessive disorder which characterized with a marked clinical heterogeneity. The gene responsible for WD located in 13q14.3 chromosome, contains 21 exons and codes copper specific transporting P-type adenosinetriphosphatase (ATPase) (ATP7B). Mutations ATP7B change biosynthetic role of ATPase cell leading to damaged billiary excretion its accumulation the liver, brain, cornea other tissues. Until now, it has been described more than 400 mutations...
ABSTRACT Background Mutations in GNAL (DYT25) have recently been established as the first confirmed cause of focal or segmental adult‐onset dystonia. Mutation carriers show craniocervical involvement; however, mutational and phenotypic spectrum remain to be further characterized, guidelines for diagnostic testing need established. Methods The authors used Sanger sequencing test changes coding splice‐site regions 236 Serbian patients suffering from isolated dystonia with involvement. Results...