A5069634240- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Restless Legs Syndrome Research
- Epilepsy research and treatment
- Transcranial Magnetic Stimulation Studies
- Genetic Neurodegenerative Diseases
- Botulinum Toxin and Related Neurological Disorders
- Neuroscience and Neural Engineering
- Diet and metabolism studies
- Advanced Neuroimaging Techniques and Applications
- Impact of Technology on Adolescents
- Advanced MRI Techniques and Applications
- Dysphagia Assessment and Management
- Neuroscience and Neuropharmacology Research
- Parkinson's Disease and Spinal Disorders
- EEG and Brain-Computer Interfaces
- Pharmacological Effects and Toxicity Studies
- Glycogen Storage Diseases and Myoclonus
- Stroke Rehabilitation and Recovery
- Eating Disorders and Behaviors
- Neurological and metabolic disorders
- Autism Spectrum Disorder Research
- Obsessive-Compulsive Spectrum Disorders
- Balance, Gait, and Falls Prevention
- Migraine and Headache Studies
University of Pecs
2016-2025
University of Szeged
2024
Semmelweis University
2024
University of Debrecen
2023
Saints Cyril and Methodius University of Skopje
2022
Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș
2022
MTA-SZTE Research Group on Artificial Intelligence
2016-2021
Hungarian Academy of Sciences
2021
Resonance Research (United States)
2021
University of Tübingen
2021
The efficacy of deep brain stimulation the anterior nucleus thalamus (ANT DBS) in patients with drug-resistant epilepsy (DRE) was demonstrated double-blind Stimulation Anterior Nucleus Thalamus for Epilepsy randomized controlled trial. Medtronic Registry (MORE) aims to understand safety and longer-term effectiveness ANT DBS therapy routine clinical practice.
Abstract Based on several open‐label and case studies, repetitive transcranial magnetic stimulation (rTMS) seems to have an antidepressive effect patients with Parkinson's disease (PD). However, this hypothesis requires further confirmation. We conducted a randomized, double‐blind placebo‐controlled study evaluate the of rTMS over left dorsolateral prefrontal cortex (DLPFC) depression various motor nonmotor features PD. Twenty‐two PD mild or moderate depressive episodes were assigned into...
Abstract The origin of the high rate depression in idiopathic Parkinson's disease (PD) is unknown. We applied voxel‐based morphometry (VBM), as a sensitive tool detection gray matter MR density alterations, to find differences depressed and nondepressed PD patients. Patients with were classified into (DPD) (NDPD) groups based on Montgomery‐Åsberg Depression Rating Scale (MADRS). Subsequently, group comparisons performed between (n = 23), 27) normal healthy controls (NC, n 16). There was no...
Status dystonicus (SD) is a rare, life-threatening disorder characterized by acute worsening of generalized dystonia.This study was conducted to characterize the pathogenesis, clinical course, and prognosis SD. We reviewed records six centers analyzed them together with all cases previously reported in literature.Eighty-nine episodes occurring 68 patients were studied. The majority males (64.7%), <15 years age (58.8%), had secondary dystonia as underlying condition (37.8%). mainly tonic...
<b><i>Background:</i></b> Minimal clinically important difference (MCID) is the smallest change in an outcome, which a patient identifies as meaningful. Although 2 most frequently applied Parkinson's disease (PD) “quality of life” questionnaires (the PDQ-39 and PDQ-8) provide encouragingly similar results, their MCID thresholds appear to be vastly different. Our aim was calculate estimates for both PDQ-8 Summary Indices (PDQ-39-SI PDQ-8-SI) by utilization anchor-...
The Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) is a newly developed tool to assess disease (PD). Changes in scores on the scale over course of PD, including increasing duration and Hoehn Yahr (HY) stages, have not been described. objectives this study were analyze MDS-UPDRS Parts I through IV their differences based HY stage large cohort patients with PD. For cross-sectional study, demographic data collected, stage. Subscores analyzed using 1-way analyses...
Abstract Background : The minimal clinically important difference is the smallest change of scores meaningful to patients. Objectives We aimed calculate these threshold values in association with International Parkinson and Movement Disorder Society UPDRS (MDS‐UPDRS) Parts I II evaluate feasibility composite score Part (MDS‐UPDRS I+II) as an outcome. Methods Nine hundred eighty‐five paired investigations 365 patients were reviewed, implementing three different techniques simultaneously....
A recent evidence-based guideline demonstrated that bilateral repetitive transcranial magnetic stimulation (rTMS) over the motor cortex (M1) can improve symptoms of Parkinson's disease (PD). We conducted a randomized, double-blind, placebo-controlled study to evaluate impact M1 rTMS on depression in PD.Forty-six patients with PD and mild-to-moderate were randomly assigned active (n = 23) sham rTMS. Two group did not complete protocol because reasons unrelated study. High-frequency was...
Background . Female Parkinson’s disease (PD) patients seem to experience not only more severe motor complications and postural instability but also pronounced depression, anxiety, pain, sleep disturbances. Objective The aim of the present study was evaluate role sex as a possible independent predictor HRQoL in PD. Methods In this cross-sectional study, 621 consecutive treated at University Pécs were enrolled. Severity PD symptoms assessed by MDS-UPDRS, UDysRS, Non-Motor Symptoms Scale,...
Levodopa-carbidopa intestinal gel (LCIG) improves motor and non-motor symptoms in patients with advanced Parkinson's disease (aPD).To present the final 36-month efficacy safety results from DUOGLOBE (DUOdopa/Duopa Patients Advanced Disease - a GLobal OBservational Study Evaluating Long-Term Effectiveness; NCT02611713).DUOGLOBE was an international, prospective, long-term, real-world, observational study of aPD initiating LCIG routine clinical care. The primary endpoint change...
One of the possible pathomechanisms sudden death in epilepsy (SUDEP) is a postictal dysregulation autonomic nervous system. We performed heart rate variability (HRV) analysis periictal state to analyze whether cardiac disturbance exists after an epileptic seizure.We included 31 video-EEG-ECG recordings patients with who had consecutively undergone pre-surgical evaluation. Nine generalized tonic-clonic (GTCS), 15 complex partial, and seven simple motor seizures were included. HRV was...
The aim of this longitudinal study was to investigate changes migraine-related brain white matter hyperintensities 3 years after an initial study. Baseline quantitative magnetic resonance imaging (MRI) studies migraine patients with hemispheric performed in 2009 demonstrated signs tissue damage within the hyperintensities. appeared most frequently deep frontal lobe a similar average hyperintensity size all lobes. Since patient group repeated attacks were only known risk factors for...
Introduction . Among the nonmotor features of Parkinson’s disease (PD), cognitive impairment is one most troublesome problems. New diagnostic criteria for mild and major neurocognitive disorder (NCD) in PD were established by Diagnostic Statistical Manual Mental Disorders 5th edition (DSM-5). The aim our study was to establish accuracy widely used screening tests NCD PD. Methods Within scope we evaluated sensitivity specificity different neuropsychological (Addenbrooke’s Cognitive...
Abstract A common brain-related feature of addictions is the altered function higher-order brain networks. Growing evidence suggests that Internet-related are also associated with breakdown functional Taking into consideration limited number studies used in previous Internet addiction (IA), our aim was to investigate correlates IA default mode network (DMN) and inhibitory control (ICN). To observe these relationships, task-related fMRI responses verbal Stroop non-verbal Stroop-like tasks...
Aim: A Delphi expert consensus panel proposed that fulfilling ≥1 of the '5-2-1 criteria' (≥five-times daily oral levodopa use, ≥two hours with 'Off' symptoms or ≥one hour troublesome dyskinesia) suggests advanced Parkinson's disease (PD). Patients & methods: DUOdopa/Duopa in Advanced PD – a GLobal OBservational Study Evaluating Long-Term Effectiveness (DUOGLOBE) is single-arm, postmarketing, observational, long-term effectiveness study levodopa–carbidopa intestinal gel (LCIG) for PD....
ABSTRACT Background Levodopa‐carbidopa intestinal gel (LCIG) is administered directly to the small intestine of patients with advanced Parkinson's disease (APD) help maintain stable plasma levodopa levels. Objective The objective this study was investigate effect LCIG in reducing polypharmacy for treatment APD. Methods COmedication Study assessing Mono‐ and cOmbination therapy levodopa‐carbidopa inteStinal (COSMOS) a large, real‐world, multinational observational investigating comedication...
Levodopa-carbidopa intestinal gel (LCIG) is an established treatment for improving motor and some non-motor symptoms (NMS) in patients with advanced Parkinson's disease (PD). Prospective long-term data routine clinical practice are limited.Assess LCIG effectiveness safety PD after 12 months during real-world practice.Duodopa/Duopa disease-a global observational study evaluating (DUOGLOBE) (NCT02611713) ongoing, prospective, multinational, of LCIG-naïve treated as part practice; 3 years...