A5004752606- Parkinson's Disease Mechanisms and Treatments
- Amyotrophic Lateral Sclerosis Research
- RNA Research and Splicing
- Adenosine and Purinergic Signaling
- Neurological disorders and treatments
- Endoplasmic Reticulum Stress and Disease
- Obsessive-Compulsive Spectrum Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Dysphagia Assessment and Management
- Forensic Toxicology and Drug Analysis
- Hormonal and reproductive studies
- Cancer Mechanisms and Therapy
- Restless Legs Syndrome Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Heavy Metal Exposure and Toxicity
- RNA regulation and disease
- Balance, Gait, and Falls Prevention
- Neurogenetic and Muscular Disorders Research
- Ion channel regulation and function
- Folate and B Vitamins Research
- Neuroscience and Neuropharmacology Research
- Glycogen Storage Diseases and Myoclonus
- Neurological diseases and metabolism
- Lysosomal Storage Disorders Research
- Genetic Neurodegenerative Diseases
North Estonia Medical Centre
2017-2025
Grenoble Institute of Neurosciences
2024
Université Grenoble Alpes
2024
Centre Hospitalier Universitaire de Grenoble
2024
University of Tartu
2010-2020
Tartu University Hospital
2015
The objective of this study was to investigate factors affecting health-related quality life (HRQoL) among Estonian persons with Parkinson's disease (PD). 268 PD were evaluated using: the Movement Disorder Society Unified Disease Rating Scale (MDS-UPDRS); Hoehn and Yahr scale (HY); Schwab England Activities Daily Living (SE-ADL); Beck Depression Inventory (BDI); Mini Mental State Examination (MMSE); Questionnaire (PDQ-39). Additional questions on clinical socio-demographic variables asked...
The Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) is a newly developed tool to assess disease (PD). Changes in scores on the scale over course of PD, including increasing duration and Hoehn Yahr (HY) stages, have not been described. objectives this study were analyze MDS-UPDRS Parts I through IV their differences based HY stage large cohort patients with PD. For cross-sectional study, demographic data collected, stage. Subscores analyzed using 1-way analyses...
Blood-based biomarkers for motor neuron disease are needed better diagnosis, progression prediction, and clinical trial monitoring. We used whole blood-derived total RNA performed transcriptome analysis to compare the gene expression profiles in (motor neurone disease) MND patients control subjects. compared 42 aged sex-matched healthy controls described profile characteristic MND. In addition formal differential analysis, we functional annotation of genomics data identified molecular...
Introduction . The purpose of this study was to demonstrate the frequency and severity nonmotor symptoms their correlations with a wide range demographic clinical factors in large cohort patients Parkinson’s disease (PD). Methods 268 PD were assessed using validated Movement Disorders Society’s Unified Disease Rating Scale (MDS-UPDRS), Beck Depression Inventory (BDI), Questionnaire (PDQ-39), Hoehn Yahr scale (HY), Schwab England Activities Daily Living (SE-ADL) Scale, Minimental State...
Wolfram syndrome, caused by mutations in the wolframin (Wfs1) gene, is characterised juvenile-onset diabetes mellitus, progressive optic atrophy, insipidus and deafness. Diabetes tend to start earlier boys. This study investigated sex differences longitudinal changes blood glucose concentration (BGC) wolframin-deficient mice (Wfs1KO) compared their plasma proinsulin insulin levels with those of wild-type (wt) mice. Non-fasting BGC was measured weekly 42 (21 males) from both groups at nine...
Blood-based biomarkers for motor neuron disease are needed better diagnosis, progression prediction, and clinical trial monitoring. We used whole blood-derived total RNA performed transcriptome analysis to compare the gene expression profiles in (motor neurone disease) MND patients control subjects. compared 42 aged sex-matched healthy controls described profile characteristic MND. In addition formal differential analysis, we functional annotation of genomics data identified molecular...
Abstract An irreversible extrapyramidal syndrome occurs in man after intravenous abuse of “homemade” methcathinone (ephedrone, Mcat) that is contaminated with manganese (Mn) and accompanied by altered basal ganglia function. Both Mcat Mn can cause alterations nigrostriatal function but it remains unknown whether the effects ‘homemade’ drug seen are due to or a combination both. To determine how toxicity occurs, we have investigated 4-week intraperitoneal administration (30 mg/kg t.i.d) (100...
Objective: To examine the genetic variability of Estonian Parkinson´s disease (PD) patients using an ongoing epidemiological study in combination with a analysis.Methods: This was community-based screening 189 PD and 158 age sex matched controls screened for potential mutations 9 genes nextgeneration sequencing multiplex ligation-dependent probe amplification method.Different clinimetric scales questionnaires were used to assess clinical characteristics severity disease.Results: The overall...
The impact of subthalamic nucleus (STN) deep brain stimulation (DBS) on neuropsychiatric fluctuations in Parkinson´s disease (PD) remains unclear. Neuropsychiatric Fluctuations Scale (NFS) can help to fill this gap, directly measuring between the OFF- and ON-medication conditions. NFS provides NFS-plus (hyperdopaminergic) NFS-minus (hypodopaminergic) sub-scores. Based these, global scores express overall magnitude symptoms both states. total fluctuation score (TFS) represents difference ON-...
Tureotoksiline perioodiline paraluus on vaga haruldane hupokaleemilise paraluusi variant, mille ravi erineb perioodilise ravist ning millele tuleks seega jarsku tekkinud lihasnorkuse ja hupokaleemia korral kindlasti moelda. Kilpnaarmehormoone peaks sellistel patsientidel kontrollima ka siis, kui tureotoksikoosi nahtusid hospitaliseerimisel ei esine. Kuigi tureotoksiline usna healoomuline seisund, tohi sellesse kergekaeliselt suhtuda – kaasneda voivad eluohtlikud sudamerutmihaired...