A5056589943- Parkinson's Disease Mechanisms and Treatments
- Forensic Toxicology and Drug Analysis
- Heavy Metal Exposure and Toxicity
- Genetic Neurodegenerative Diseases
- Neuroethics, Human Enhancement, Biomedical Innovations
- Neuroscience and Neuropharmacology Research
- Neurological disorders and treatments
- Attention Deficit Hyperactivity Disorder
- Psychedelics and Drug Studies
- Alzheimer's disease research and treatments
- Lysosomal Storage Disorders Research
- Thyroid Disorders and Treatments
- Acute Ischemic Stroke Management
- Amino Acid Enzymes and Metabolism
- Plant-based Medicinal Research
- interferon and immune responses
- Migraine and Headache Studies
- Dementia and Cognitive Impairment Research
- Electrochemical sensors and biosensors
- Nitric Oxide and Endothelin Effects
- Botulinum Toxin and Related Neurological Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Cancer, Hypoxia, and Metabolism
- Neurological diseases and metabolism
University of Tartu
2007-2023
North Estonia Medical Centre
2015-2020
Background – Parkinsonian syndrome related to intravenous use of a ‘designer’ psychostimulant, derived from pseudoephedrine using potassium permanganate as the oxidant, has been observed in drug addicts Estonia. Objective To describe symptomatology four young patients, history administration and chemical analysis batch. Methods Mental motor function quality life were scored ephedrone was analyzed electrospray mass spectrometry. Manganese content final synthetic mixture Inductively Coupled...
During recent years, a syndrome of hypokinesia, dysarthria, dystonia, and postural impairment, related to intravenous use “designer” psychostimulant derived from pseudoephedrine using potassium permanganate as the oxidant, has been observed in drug addicts several countries Eastern Europe with some cases also Western countries. A levodopa unresponsive Parkinsonian occurs within few months abusing homemade mixture containing ephedrone (methcathinone) manganese. The development this...
Methcathinone abuse is a new cause of manganism. The psychostimulant prepared from pseudoephedrine using potassium permanganate as an oxidant. We describe the clinical, biological, neuroimaging characteristics and follow-up results in large Estonian cohort intravenous methcathinone users.During 2006-2012 we studied 38 abusers with mean age 33 years. Subjects were rated by Unified Parkinson's Disease Rating Scale (UPDRS), Hoehn Yahr (HY), Schwab England (SE) rating scales. Twenty-four cases...
Sikk K, Taba P, Haldre S, Bergquist J, Nyholm D, Askmark H, Danfors T, Sörensen Thurfjell L, Raininko R, Eriksson Flink Färnstrand C, Aquilonius S-M. Clinical, neuroimaging and neurophysiological features in addicts with manganese-ephedrone exposure. Acta Neurol Scand: 2010: 121: 237–243.© 2009 The Authors Journal compilation © Blackwell Munksgaard. Objective – To identify biomarkers supporting the clinical diagnosis of manganism patients several years after exposure to manganese (Mn)....
Methcathinone (ephedrone) is relatively easily accessible for abuse. Its users develop an extrapyramidal syndrome and it not known if this caused by methcathinone itself, side-ingredients (manganese), or both. In the present study we aimed to clarify molecular mechanisms underlying condition. We analyzed whole genome gene expression patterns of peripheral blood from 20 matched controls. Gene profile data was Bayesian modelling functional annotation. order verify genechip results performed...
Objective: To examine the genetic variability of Estonian Parkinson´s disease (PD) patients using an ongoing epidemiological study in combination with a analysis.Methods: This was community-based screening 189 PD and 158 age sex matched controls screened for potential mutations 9 genes nextgeneration sequencing multiplex ligation-dependent probe amplification method.Different clinimetric scales questionnaires were used to assess clinical characteristics severity disease.Results: The overall...
Ulevaates on kirjeldatud toksilist parkinsonistlikku sundroomi patsientidel, kes sustivad Sudafedist (pseudoefedriinist) valmistatud lahust, mis lisaks psuhhostimulant efedroonile (metkatinoon) sisaldab korvalproduktina suures hulgas mangaani. Peamisteks sumptomiteks tasakaalu-, konnaku- ja konehaired, jasemete dustooniad ning bradukineesia. Toksilise ekstrapuramidaalse kliiniline pilt sarnaneb manganismiga, mida varem mangaani kroonilise inhalatsiooni tagajarjel toostustoolistel. Efedrooni...
Artiklis on kirjeldatud kongenitaalse nagemishaire ja kasvupeetusega 6aastase poisi haigusjuhtu, kellel diagnoositi septo-optilise dusplaasia sundroom (SOD). Meie teada see esimene haigusjuhu kirjeldus Eestis. Poisil esineb haigusele iseloomulik nagemisnarvide -diskide arengudefekt, mis pohjustab taielikku pimedust, ning isoleeritud kasvuhormooni puudulikkusest tingitud kasvupeetus kulgvatsakesi eraldava vaheseina – septum pellucidum’i puudumine. Lisaks antud luhike ulevaade sundroomi...