A5049440797- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Botulinum Toxin and Related Neurological Disorders
- RNA regulation and disease
- Genetics and Neurodevelopmental Disorders
- Cellular transport and secretion
- Neurological diseases and metabolism
- Dysphagia Assessment and Management
- Genetic Neurodegenerative Diseases
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Lysosomal Storage Disorders Research
- Nerve injury and regeneration
- Skin and Cellular Biology Research
- Biochemical Analysis and Sensing Techniques
- Health Systems, Economic Evaluations, Quality of Life
- Pluripotent Stem Cells Research
- Sensory Analysis and Statistical Methods
- Amyotrophic Lateral Sclerosis Research
- Balance, Gait, and Falls Prevention
- Olfactory and Sensory Function Studies
- Neurology and Historical Studies
- Restless Legs Syndrome Research
- Hereditary Neurological Disorders
- melanin and skin pigmentation
- Salivary Gland Disorders and Functions
Tartu University Hospital
2015-2023
University of Tartu
2014-2023
The objective of this study was to investigate factors affecting health-related quality life (HRQoL) among Estonian persons with Parkinson's disease (PD). 268 PD were evaluated using: the Movement Disorder Society Unified Disease Rating Scale (MDS-UPDRS); Hoehn and Yahr scale (HY); Schwab England Activities Daily Living (SE-ADL); Beck Depression Inventory (BDI); Mini Mental State Examination (MMSE); Questionnaire (PDQ-39). Additional questions on clinical socio-demographic variables asked...
The Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) is a newly developed tool to assess disease (PD). Changes in scores on the scale over course of PD, including increasing duration and Hoehn Yahr (HY) stages, have not been described. objectives this study were analyze MDS-UPDRS Parts I through IV their differences based HY stage large cohort patients with PD. For cross-sectional study, demographic data collected, stage. Subscores analyzed using 1-way analyses...
Parkinson's Disease is a progressive neurodegenerative disease, characterized by symptoms of motor impairment, resulting from the loss dopaminergic neurons in midbrain, however non-neuronal are also common. Although great advances have been made pathogenic understanding nervous system, little known about molecular alterations occurring other organ systems. In addition, higher rate melanoma and non-melanoma skin cancer has observed population, indicating crosstalk between these diseases.To...
Transcriptomics in Parkinson’s disease offers insights into the pathogenesis of but obtaining brain tissue has limitations. In order to bypass this issue, we profile and compare differentially expressed genes enriched pathways (KEGG) two peripheral tissues (blood skin) 12 patients healthy controls using RNA-sequencing technique validation with RT-qPCR. Furthermore, our results previous post mortem blood robust rank aggregation method. The show no overlapping or vs. skin sample sets (25 1068...
Dystonia is a debilitating hyperkinetic movement disorder, which can be transmitted as monogenic trait. Here, we describe homozygous frameshift, nonsense, and missense variants in TSPOAP1, encodes the active-zone RIM-binding protein 1 (RIMBP1), genetic cause of autosomal recessive dystonia 7 subjects from 3 unrelated families. Subjects carrying loss-of-function presented with juvenile-onset progressive generalized dystonia, associated intellectual disability cerebellar atrophy. Conversely,...
Introduction . The purpose of this study was to demonstrate the frequency and severity nonmotor symptoms their correlations with a wide range demographic clinical factors in large cohort patients Parkinson’s disease (PD). Methods 268 PD were assessed using validated Movement Disorders Society’s Unified Disease Rating Scale (MDS-UPDRS), Beck Depression Inventory (BDI), Questionnaire (PDQ-39), Hoehn Yahr scale (HY), Schwab England Activities Daily Living (SE-ADL) Scale, Minimental State...
Mesencephalic astrocyte-derived neurotrophic factor (MANF) and cerebral dopamine (CDNF) promote the survival of midbrain neurons in animal models Parkinson's disease (PD). However, little is known about endogenous concentrations MANF CDNF human PD patients, their relation to pathogenesis. Our main objective was study whether circulating differ between patients controls, if they correlate with clinical parameters. Levels were studied for first time.MANF levels measured from serum samples 34...
Patients with Parkinson's disease (PD) are compromised by poor oral condition due to oropharyngeal bradykinesia, dysphagia, and the side effects of treatment. Intrasalivary gland injections Botulinum neurotoxin type A (BNT-A) have been known treat sialorrhea effectively in these patients. However, decreased amount saliva reduces self-cleaning ability that deteriorates hygiene increases dental caries. The aim this study was determine changes microflora patients PD treated for means...
Abstract Objectives Levodopa is the most effective therapy for treating Parkinson's disease ( PD ); however, side effects such as dyskinesias and motor fluctuations may occur after some years of its usage. The aims this study were to assess frequency factors associated with complications among patients on levodopa treatment. Methods In a cross‐sectional carried out in 2010–2013, clinical data treatment details collected. Logistic regression expressed by odd ratios OR ) 95% confidence...
Abstract Repetitive elements (RE) constitute the majority of human genome and have a range functions both structural regulatory on genomic function gene expression. RE overexpression has been observed in several neurodegenerative diseases, consistent with observation aberrant expression posing mutagenic threat. Despite reports that associate PD no study comprehensively analysed role these disease. This presents first genome-wide analysis to date. Analysis RNA-sequencing data 12 patients...
Objectives A previous epidemiological study of Parkinson's disease (PD) in the county Tartu, Estonia, found an adjusted prevalence rate 152/100 000 persons. We aimed to determine PD almost 20 years later, as well evaluate any dynamic changes frequency compared first study. Methods cross-sectional, community-based was conducted over 2010-2016 Estonia. Multiple case-finding sources, including information from neurologists, family doctors, local Society, nursing institutions, and database...
We report the changed levels of serum amyloid alpha, an immunologically active protein, in Parkinson's disease (PD) patients' peripheral tissues. have previously shown that Saa-1 and -2 (serum alpha-1,-2, genes) were among top downregulated genes PD skin, using whole-genome RNA sequencing. In current study, we characterized gene protein expression profiles skin blood samples from patients with confirmed diagnosis age/sex matched controls. qRT-PCR analysis demonstrated downregulation...
<b><i>Background:</i></b> There is lack of data on the incidence Parkinson’s disease (PD) based repeat studies. Mortality rates PD in Estonia have never been studied before. <b><i>Objectives:</i></b> To estimate and mortality Estonia, to compare current with those prior epidemiological study Estonia, examine reported causes death population. <b><i>Methods:</i></b> Eligible subjects were identified from multiple...
Substantia nigra hyperechogenicity is a promising biomarker for Parkinson disease (PD). has previously been established as useful diagnostic criterion in several European and Asian patient cohorts. However, cutoff values substantia remain unknown most populations. This study validated the accuracy of large cohort patients with PD Estonia.The included 300 from Estonia, representing 10% national population, 200 healthy control participants. To define optimal value cohort, data single...
Background: Little information is available on the official postgraduate and subspecialty training programs in movement disorders (MD) Europe North Africa. Objective: To survey accessible MD clinical these regions. Methods: We designed a different medical fields, at specialized levels. assessed characteristics of participants facilities for care their respective countries. examined whether there are structured, or even accredited postgraduate, neurology, neurosurgery, internal medicine,...
Objective: To examine the genetic variability of Estonian Parkinson´s disease (PD) patients using an ongoing epidemiological study in combination with a analysis.Methods: This was community-based screening 189 PD and 158 age sex matched controls screened for potential mutations 9 genes nextgeneration sequencing multiplex ligation-dependent probe amplification method.Different clinimetric scales questionnaires were used to assess clinical characteristics severity disease.Results: The overall...
ABSTRACT Dystonia is a debilitating hyperkinetic movement disorder, frequently transmitted as monogenic trait. Here, we describe homozygous frameshift, nonsense and missense variants in TSPOAP1 , encoding the active zone RIM-binding protein 1 (RIMBP1), novel genetic cause of autosomal recessive dystonia seven subjects from three unrelated families. Subjects carrying loss-of-function presented with juvenile- onset progressive generalized dystonia, associated intellectual disability cerebellar...