A5072970464- Obsessive-Compulsive Spectrum Disorders
- Parkinson's Disease Mechanisms and Treatments
- RNA regulation and disease
- Attention Deficit Hyperactivity Disorder
- Neuroscience and Music Perception
- Sexuality, Behavior, and Technology
- Child Nutrition and Feeding Issues
- Neurotransmitter Receptor Influence on Behavior
- Nuclear Receptors and Signaling
- Cutaneous Melanoma Detection and Management
- Alzheimer's disease research and treatments
- Sexual function and dysfunction studies
- melanin and skin pigmentation
- RNA Research and Splicing
- Neural and Behavioral Psychology Studies
- Infant Health and Development
- Lysosomal Storage Disorders Research
- Autism Spectrum Disorder Research
- Psychosomatic Disorders and Their Treatments
- Skin and Cellular Biology Research
- Botulinum Toxin and Related Neurological Disorders
- Folate and B Vitamins Research
- Mosquito-borne diseases and control
- Body Image and Dysmorphia Studies
- Viral Infections and Vectors
Charité - Universitätsmedizin Berlin
2019-2024
Universitätsmedizin Göttingen
2022-2024
Humboldt-Universität zu Berlin
2021
Freie Universität Berlin
2021
University of Tartu
2017-2020
Parkinson's Disease is a progressive neurodegenerative disease, characterized by symptoms of motor impairment, resulting from the loss dopaminergic neurons in midbrain, however non-neuronal are also common. Although great advances have been made pathogenic understanding nervous system, little known about molecular alterations occurring other organ systems. In addition, higher rate melanoma and non-melanoma skin cancer has observed population, indicating crosstalk between these diseases.To...
Transcriptomics in Parkinson’s disease offers insights into the pathogenesis of but obtaining brain tissue has limitations. In order to bypass this issue, we profile and compare differentially expressed genes enriched pathways (KEGG) two peripheral tissues (blood skin) 12 patients healthy controls using RNA-sequencing technique validation with RT-qPCR. Furthermore, our results previous post mortem blood robust rank aggregation method. The show no overlapping or vs. skin sample sets (25 1068...
West Nile Virus (WNV) infections are increasingly detected in birds and horses central Europe, with the first mosquito-borne autochthonous human infection Germany 2019. Human typically asymptomatic, occasional severe neurological disease. Because of a low number cases awareness regarding potential is WNV diagnostic testing not routine. We tested cerebrospinal fluid (CSF) samples from unsolved encephalitis meningitis Berlin 2019 to 2020, describe WNV-encephalitis case 33-year-old kidney...
Abstract Repetitive elements (RE) constitute the majority of human genome and have a range functions both structural regulatory on genomic function gene expression. RE overexpression has been observed in several neurodegenerative diseases, consistent with observation aberrant expression posing mutagenic threat. Despite reports that associate PD no study comprehensively analysed role these disease. This presents first genome-wide analysis to date. Analysis RNA-sequencing data 12 patients...
We report the changed levels of serum amyloid alpha, an immunologically active protein, in Parkinson's disease (PD) patients' peripheral tissues. have previously shown that Saa-1 and -2 (serum alpha-1,-2, genes) were among top downregulated genes PD skin, using whole-genome RNA sequencing. In current study, we characterized gene protein expression profiles skin blood samples from patients with confirmed diagnosis age/sex matched controls. qRT-PCR analysis demonstrated downregulation...
<strong>Background:</strong> Tic disorders belong to the broad spectrum of pediatric and adult movement disorders. The wide variability in clinical presentations, applied assessment tools, treatments are poorly understood. <strong>Objectives: </strong>To map practices knowledge base disorder clinicians concerning features, pathophysiology, treatment approaches tic <strong>Methods:</strong> A 33-item survey was developed by Disorders Tourette syndrome Study Group members Movement Disorder...
Early research suggested that compulsive sexual behavior (CSB) and paraphilic interests (PI) are more prevalent in adults with primary tic disorders compared to the general population. However, recent data on this topic remain scarce. We conducted an anonymous online survey capturing CSB PI adult patients disorders. also explored role of antipsychotic medication impact neuropsychiatric comorbidities like attention-deficit hyperactivity disorder depression. In total, 62 participants (26...
Tics describe a wide range of sudden and repetitive behaviors. Their multifaceted clinical features may resemble other explosive behaviors, including episodes aggression toward others (allo-aggression) reported by subjects without tics. Here, we document 3 exemplary cases that help disentangle allo-aggressive behaviors from tics.We report who presented with an array complex most notably allo-aggression (eg, kicking, hitting, slapping biting others, or pushing someone off bike), which were...
Abstract Background It has been proposed that tics and premonitory urges in primary tic disorders (PTD), like Tourette syndrome, are a manifestation of sensorimotor noise. However, patients with show no obvious movement imprecision everyday life. One reason could be have strategies to compensate for noise disrupts performance (ie, is task‐relevant). Objectives Our goal was unmask effects elevated on the variability voluntary movements PTD. Methods We tested 30 adult PTD (23 male) matched...