Suzan Brown
- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- EEG and Brain-Computer Interfaces
- Neurological disorders and treatments
- Ion channel regulation and function
- Functional Brain Connectivity Studies
Western University
1985-2018
University Hospital
1986
The efficacy of deep brain stimulation the anterior nucleus thalamus (ANT DBS) in patients with drug-resistant epilepsy (DRE) was demonstrated double-blind Stimulation Anterior Nucleus Thalamus for Epilepsy randomized controlled trial. Medtronic Registry (MORE) aims to understand safety and longer-term effectiveness ANT DBS therapy routine clinical practice.
Purpose: Lacosamide selectively enhances slow inactivation of voltage-gated sodium channels to achieve seizure reduction. We studied the effect intravenous lacosamide given as one three single doses on EEG and electrocardiogram, well its tolerability in patients with drug-resistant epilepsy. Methods: This Canadian, investigator-initiated, multicenter, double-blind study recruited refractory focal epilepsy admitted a monitoring unit. Participants received loading dose 100, 200, or 400 mg over...