A5087408581- Neurological disorders and treatments
- EEG and Brain-Computer Interfaces
- Vagus Nerve Stimulation Research
- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
- Epilepsy research and treatment
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Photochromic and Fluorescence Chemistry
- Neuroscience of respiration and sleep
- Adenosine and Purinergic Signaling
- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- Heart Rate Variability and Autonomic Control
- Neurosurgical Procedures and Complications
- Nicotinic Acetylcholine Receptors Study
- Autoimmune Neurological Disorders and Treatments
- Ultrasound and Hyperthermia Applications
- Botulinum Toxin and Related Neurological Disorders
- Memory and Neural Mechanisms
- Ion channel regulation and function
- Drug Transport and Resistance Mechanisms
- Gout, Hyperuricemia, Uric Acid
- Myasthenia Gravis and Thymoma
- Cytomegalovirus and herpesvirus research
Ghent University
2015-2025
Ghent University Hospital
2013-2024
Eindhoven University of Technology
2022-2024
Tampere University Hospital
2023
Hospital de Santa Maria
2023
Kempenhaeghe
2023
Tampere University
2023
University of Amsterdam
2016
Universitair Ziekenhuis Brussel
2015
The efficacy of deep brain stimulation the anterior nucleus thalamus (ANT DBS) in patients with drug-resistant epilepsy (DRE) was demonstrated double-blind Stimulation Anterior Nucleus Thalamus for Epilepsy randomized controlled trial. Medtronic Registry (MORE) aims to understand safety and longer-term effectiveness ANT DBS therapy routine clinical practice.
In this study, we present long-term results from patients with medial temporal lobe (MTL) epilepsy treated deep brain stimulation (DBS). Since 2001, 11 (8M) refractory MTL underwent DBS. When unilateral DBS failed to decrease seizures by > 90%, a switch bilateral was proposed. After mean follow-up of 8.5 years (range: 67-120 months), 6/11 had ≥ 90% seizure frequency reduction 3/6 seizure-free for 3 years; three 40%-70% and two < 30% reduction. 3/5 switching further improved outcome. Uni- or...
The intrahippocampal kainic acid (IHKA) mouse model is an extensively used in vivo to investigate the pathophysiology of mesial temporal lobe epilepsy (mTLE) and develop novel therapies for drug-resistant epilepsy. It characterized by profound hippocampal sclerosis spontaneously occurring seizures with a major role injected damaged hippocampus, but little known about excitability specific subregions. purpose this study was electrophysiologically characterize subregions chronic phase induced...
See Lenck-Santini (doi:10.1093/awx205) for a scientific commentary on this article. Epileptic seizures represent altered neuronal network dynamics, but the temporal evolution and cellular substrates of activity patterns associated with spontaneous are not fully understood. We used simultaneous recordings from multiple neurons in hippocampus neocortex rats chronic lobe epilepsy to demonstrate that subsets cells discharge highly stereotypical sequential pattern during ictal events, these were...
The locus coeruleus (LC)-noradrenaline (NA) system plays a crucial role in modulating neuronal excitability and plasticity. In epilepsy, the LC-NA an important regulating seizure thresholds severity, with elevated NA release mediating seizure-suppressing effects of vagus nerve stimulation (VNS). We investigated whether chemogenetic LC activation is able to increase hippocampal affect electrophysiology anesthetized rats. 22 male Sprague-Dawley rats were injected viral vector AAV9-hSyn-NE2m...
Up to 30 % of epilepsy patients suffer from drug-resistant (DRE). The search for innovative therapies is therefore important close the existing treatment gap in these patients. adenosinergic system possesses potent anticonvulsive effects, mainly through adenosine A1 receptor (A1R). However, clinical application A1R agonists hindered by severe systemic side effects. To achieve local modulation A1Rs, we employed a photopharmacological approach using caged version agonist...
Summary Objective One third of epilepsy patients do not become seizure‐free using conventional medication. Therefore, there is a need for alternative treatments. Preclinical research designer receptors exclusively activated by drugs (DREADDs) has demonstrated initial success in suppressing epileptic activity. Here, we evaluated whether long‐term chemogenetic seizure suppression could be obtained the intraperitoneal kainic acid rat model temporal lobe epilepsy, when DREADDs were selectively...
BackgroundTranscranial direct current stimulation (tDCS) is used to modulate neuronal activity, but the exact mechanism of action (MOA) unclear. This study investigates tDCS-induced modulation corticospinal excitability and underlying MOA. By anesthetizing scalp before applying tDCS by stimulating cheeks, we investigated whether peripheral and/or cranial nerves contributes effects on excitability.Materials MethodsIn a randomized cross-over study, four experimental conditions with anodal were...
Various neurostimulation modalities have emerged in the field of epilepsy. Despite fact that delivery an electrical current to hyperexcitable epileptic brain might, at first, seem contradictory, has become established therapeutic option with a promising efficacy and adverse effects profile. In "responsive" strategy is interfere as early possible accumulation seizure activity prematurely abort or even prevent upcoming seizure. The design technology required for responsive stimulation more...
BackgroundRecent experiments in rats have demonstrated significant effects of VNS on hippocampal excitability but were partially attributed to hypothermia, induced by the applied parameters.ObjectiveTo allow meaningful preclinical research mechanisms and translation rodent results clinical trials, we aimed identify non-hypothermia inducing parameters that significantly affect excitability.MethodsVNS was administered cycles 30 s including either 0.1, 0.16, 0.25, 0.5, 1.5, 3 or 7 ON time...
Vagus nerve stimulation (VNS) is a widely used neuromodulation technique that currently or being investigated as therapy for wide array of human diseases such epilepsy, depression, Alzheimer’s disease, tinnitus, inflammatory diseases, pain, heart failure and many others. Here, we report pronounced decrease in brain core temperature during VNS freely moving rats. Two hours rapid cycle (7s on/18s off) decreased by around [Formula: see text]C, while standard (30[Formula: text]s on/300[Formula:...
Abstract Objective Deep brain stimulation (DBS) is an increasingly applied treatment for various neuropsychiatric disorders including drug‐resistant epilepsy, and it may be optimized by rationalizing the protocol based on increased knowledge of its mechanism action. We evaluated effects minutes to hours hippocampal DBS evoked potentials (EPs) local field (LFPs) in freely moving male rats further investigate some previously proposed mechanisms Methods Hippocampal high‐frequency (130 Hz) was...
We report the design, synthesis, and validation of novel compound photocaged N6-cyclopentyladenosine (cCPA) to achieve precisely localized timed release parent adenosine A1 receptor agonist CPA using 405 nm light. Gi protein-coupled receptors (A1Rs) modulate neurotransmission via pre- post-synaptic routes. The dynamics CPA-mediated effect on neurotransmission, characterized by fast activation slow recovery, make it possible implement a closed-loop control paradigm. strength is monitored as...