A5017615853- Antimicrobial Peptides and Activities
- Bacterial biofilms and quorum sensing
- Inhalation and Respiratory Drug Delivery
- Analytical Chemistry and Chromatography
- Chemical Synthesis and Analysis
- Protein purification and stability
- Gut microbiota and health
- Pharmaceutical Economics and Policy
- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Biochemical and Structural Characterization
- Pharmaceutical Quality and Counterfeiting
- Oral microbiology and periodontitis research
- RNA Interference and Gene Delivery
- Herbal Medicine Research Studies
- Analytical Methods in Pharmaceuticals
- Probiotics and Fermented Foods
- Drug Transport and Resistance Mechanisms
- Microfluidic and Capillary Electrophoresis Applications
- Pharmaceutical studies and practices
- Clostridium difficile and Clostridium perfringens research
- SARS-CoV-2 and COVID-19 Research
- Biosensors and Analytical Detection
- Safe Handling of Antineoplastic Drugs
- Acoustic Wave Resonator Technologies
Ghent University
2016-2025
Ghent University Hospital
2011-2024
Recent research has provided fascinating indications and evidence that the host health is linked to its microbial inhabitants. Due development of high-throughput sequencing technologies, more data covering composition changes in different disease types are emerging. However, this information dispersed over a wide variety medical biomedical disciplines.Disbiome database which collects presents published microbiota-disease standardized way. The diseases classified using MedDRA classification...
Cell-penetrating peptides (CPPs) are a group of peptides, which have the ability to cross cell membrane bilayers. CPPs themselves can exert biological activity and be formed endogenously. Fragmentary studies demonstrate their enhance transport different cargoes across blood-brain barrier (BBB). However, comparative, quantitative data on BBB permeability currently lacking. Therefore, in vivo characteristics five chemically diverse CPPs, i.e. pVEC, SynB3, Tat 47-57, transportan 10 (TP10)...
Quorum-sensing (QS) peptides are biologically attractive molecules, with a wide diversity of structures and prone to modifications altering or presenting new functionalities. Therefore, the Quorumpeps database (http://quorumpeps.ugent.be) is developed give structured overview QS oligopeptides, describing their microbial origin (species), functionality (method, result receptor), peptide links chemical characteristics (3D-structure-derived physicochemical properties). The observed within this...
Blood-brain barrier peptides (BBPs) have a large range of biomedical applications since they can cross the blood-brain based on different mechanisms. As experimental methods for identification BBPs are laborious and expensive, computational approaches necessary to be developed predicting BBPs. In this work, we describe method, BBPpred (blood-brain prediction), that efficiently identify using logistic regression. We investigate wide variety features from amino acid sequence information, then...
The role of the human microbiome on cancer progression remains unclear. Therefore, in this study, we investigated influence some quorum sensing peptides, produced by diverse commensal or pathogenic bacteria, breast cell invasion and thus outcome. Based microscopy, transcriptome Chick Chorioallantoic Membrane (CAM) analyses, four peptides (PhrG from B. subtilis, CSP S. mitis EDF E. coli, together with its tripeptide analogue) were found to promote tumour angiogenesis, thereby potentially...
Background The presence of poor quality medicines in the market is a global threat on public health, especially developing countries. Therefore, we assessed two commonly used anthelminthic drugs [mebendazole (MEB) and albendazole (ALB)] one antiprotozoal drug [tinidazole (TNZ)] Ethiopia. Methods/Principal Findings A multilevel stratified random sampling, with as strata different levels supply chain system Ethiopia, geographic areas government/privately owned outlets, was to collect samples...
Background There is a worldwide upscale in mass drug administration (MDA) programs to control the morbidity caused by soil-transmitted helminths (STHs): Ascaris lumbricoides, Trichuris trichiura and hookworm. Although anthelminthic drugs which are used for MDA supplied two pharmaceutical companies through donation, there wide range of brands available on local markets efficacy against STHs quality remain poorly explored. In present study, we evaluated albendazole (Bendex Ovis) market...
Rising population density and global mobility are among the reasons why pathogens such as SARS-CoV-2, virus that causes COVID-19, spread so rapidly across globe. The policy response to pandemics will always have include accurate monitoring of spread, this provides one few alternatives total lockdown. However, COVID-19 diagnosis is currently performed almost exclusively by reverse transcription polymerase chain reaction (RT-PCR). Although efficient, automatable, acceptably cheap, reliance on...
Cell-penetrating peptides (CPPs) are a promising tool to overcome cell membrane barriers. They have already been successfully applied as carriers for several problematic cargoes, like e.g. plasmid DNA and (si)RNA, opening doors new therapeutics. Although hundreds of CPPs described in the literature, only few commercial applications currently available. Cellular uptake studies these suffer from inconsistencies used techniques other experimental conditions, leading uncertainties about their...
Bacteria communicate with each other by the use of signaling molecules, a process called ‘quorum sensing’. One group quorum sensing molecules includes oligopeptides, which are mainly produced Gram-positive bacteria. Recently, these peptides were found to biologically influence mammalian cells, promoting i.a. metastasis cancer cells. Moreover, it was that bacteria can different central nervous system related disorders as well, e.g. anxiety, depression and autism. Research currently focuses on...
Due to the expanding and ageing world population, importance use of medicines is expected increase. However, this will lead a greater impact on ecosystem our health in long term. The concept sustainability rather slowly gaining traction currently still fragmented pharmaceutical field. A consortium researchers from five European universities therefore advocates global, systematic approach places emphasis already early stages drug development, i.e. discovery. According researchers, competent...
Up to 30 % of epilepsy patients suffer from drug-resistant (DRE). The search for innovative therapies is therefore important close the existing treatment gap in these patients. adenosinergic system possesses potent anticonvulsive effects, mainly through adenosine A1 receptor (A1R). However, clinical application A1R agonists hindered by severe systemic side effects. To achieve local modulation A1Rs, we employed a photopharmacological approach using caged version agonist...