A5023067663- Vagus Nerve Stimulation Research
- Glioma Diagnosis and Treatment
- EEG and Brain-Computer Interfaces
- Cystic Fibrosis Research Advances
- Medical Imaging Techniques and Applications
- Antimicrobial Peptides and Activities
- Neuroscience and Neural Engineering
- Salivary Gland Disorders and Functions
- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Nicotinic Acetylcholine Receptors Study
- Neurosurgical Procedures and Complications
- Voice and Speech Disorders
- Advanced Radiotherapy Techniques
- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- RNA regulation and disease
- Cancer Treatment and Pharmacology
- Advanced Neuroimaging Techniques and Applications
- Venous Thromboembolism Diagnosis and Management
- Advanced Chemical Sensor Technologies
- Neurological disorders and treatments
- Dysphagia Assessment and Management
- Olfactory and Sensory Function Studies
- COVID-19 Clinical Research Studies
Ghent University
2015-2022
Ghent University Hospital
2019-2020
UCLouvain
2015
In patients treated with vagus nerve stimulation (VNS) for drug resistant epilepsy (DRE), up to a third of will eventually not respond the therapy. As VNS therapy requires surgery device implantation, prediction response prior is desirable. It hypothesized that neurophysiological investigations related mechanisms action may help differentiate responders from non-responders initiation therapy.In prospective series DRE patients, polysomnography, heart rate variability (HRV) and cognitive event...
Vagus nerve stimulation (VNS) therapy is associated with laryngeal muscle activation and induces voice modifications, well-known side effects of the resulting from co-activation recurrent nerve. In this study, we describe non-invasive transcutaneous recording motor evoked potentials (LMEPs), which could serve as a biomarker effective individual titration in patients drug-resistant epilepsy. We recruited epileptic treated for at least 6 months VNS. Trains 600-1200 VNS pulses were delivered...
Cystic fibrosis (CF) is a fatal genetic disease associated with widespread exocrine gland dysfunction. Studies have suggested activating effects of resveratrol, naturally-occurring polyphenol compound antioxidant and anti-inflammatory properties, on CF transmembrane conductance regulator (CFTR) protein function. We assayed, in F508del-CFTR homozygous wild-type mice, the effect resveratrol salivary secretion basal conditions, response to inhibition by atropine (basal β-adrenergic-dependent...
BackgroundRecent experiments in rats have demonstrated significant effects of VNS on hippocampal excitability but were partially attributed to hypothermia, induced by the applied parameters.ObjectiveTo allow meaningful preclinical research mechanisms and translation rodent results clinical trials, we aimed identify non-hypothermia inducing parameters that significantly affect excitability.MethodsVNS was administered cycles 30 s including either 0.1, 0.16, 0.25, 0.5, 1.5, 3 or 7 ON time...
Seizures are common in patients with high-grade gliomas (30–60%) and approximately 15–30% of glioblastoma (GB) develop drug-resistant epilepsy. Reliable animal models needed to adequate treatments for glioma-related Therefore, fifteen rats were inoculated F98 GB cells (GB group) four vehicle only (control the right entorhinal cortex. MRI was performed visualize tumor presence. A subset seven two control implanted recording electrodes determine occurrence epileptic seizures video-EEG over...
AIM. Vagus nerve stimulation (VNS) modulates hippocampal dentate gyrus (DG) electrophysiology and induces hypothermia in freely moving rats. This study evaluated whether (CA1) is similarly modulated to what extent this associated with VNS-induced hypothermia. METHODS. Six rats received a first 4h session of rapid cycling VNS (7s on/18s off), while CA1 evoked potentials, EEG core temperature were recorded. In second session, external heating was applied during the 3rd 4thh counteracting...
Magnetic resonance imaging (MRI) is frequently used for preclinical treatment monitoring in glioblastoma (GB). Discriminating between tumors and tumor-associated changes challenging on vivo MRI. In this study, we compared MRI scans with ex histology to estimate more precisely the abnormal mass Epileptic seizures are a common symptom GB. Therefore, recently developed GB-associated epilepsy model from our group aim of further characterizing making it useful dedicated research. Ten days after...
The "Journées Franco-Belges de Pharmacochimie" is a recognized annual meeting in organic and medicinal chemistry known for the quality of scientific exchange conviviality. Young researchers were encouraged to present their work share ideas with senior scientists. Abstracts plenary lectures, oral communications, posters presented during are collected this report.