A5039741592- Chemical Synthesis and Analysis
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Molecular spectroscopy and chirality
- Carbohydrate Chemistry and Synthesis
- Crystallography and molecular interactions
- Adenosine and Purinergic Signaling
- Axial and Atropisomeric Chirality Synthesis
- Receptor Mechanisms and Signaling
- RNA Interference and Gene Delivery
- Cancer Treatment and Pharmacology
- Chemical Synthesis and Reactions
- Synthesis and Biological Evaluation
- Neuropeptides and Animal Physiology
- Nicotinic Acetylcholine Receptors Study
- Supramolecular Self-Assembly in Materials
- Photoreceptor and optogenetics research
- Virus-based gene therapy research
- Lipid Membrane Structure and Behavior
- Synthetic Organic Chemistry Methods
- Oxidative Organic Chemistry Reactions
- Advanced biosensing and bioanalysis techniques
- Synthesis and Reactivity of Heterocycles
- Photochromic and Fluorescence Chemistry
- Pharmacological Receptor Mechanisms and Effects
Inserm
2015-2019
Centre de Recherche Jean Pierre Aubert
2015-2019
Université de Lille
2015-2019
Centre Hospitalier Universitaire de Lille
2017-2019
Centre National de la Recherche Scientifique
2005-2011
Sorbonne Université
2009-2011
École Normale Supérieure - PSL
2011
Institut de Chimie Moléculaire de Paris : organique, inorganique et biologique
2009
Institut Lavoisier de Versailles
2005-2009
Laboratoire des Biomolécules
2009
An induced axial chirality of the biphenyl core Bip (2',1':1,2;1'',2'':3,4-dibenzcyclohepta-1,3-diene-6-amino-6-carboxylic acid) residue in terminally protected dipeptides Boc-Bip-beta-Xaa*-OMe (beta-Xaa* = L-beta(3)-HAla, L-beta(3)-HVal, L-beta(3)-HLeu, L-beta(3)-HPro, trans-(1S,2S)-ACHC, trans-(1R,2R)-ACHC, trans-(1S,2S)-ACPC, trans-(1R,2R)-ACPC) resulted an circular dichroism, revealing usefulness method for a reliable and fast assignment absolute configuration chiral beta-amino acids....
An induced axial chirality in the biphenyl core of 2',1':1,2;1'',2'':3,4-dibenzcyclohepta-1,3-diene-6-amino-6-carboxylic acid (Bip) residue, a conformationally labile, atropoisomeric, C(alpha)-tetrasubstituted alpha-amino acid, was observed by CD and (1)H NMR spectroscopic techniques linear dipeptides Boc-Bip-Xaa*-OMe where Boc=tert-butoxycarbonyl, OMe=methoxy, Xaa*=D- and/or L-Ala, -Val, -Leu, -Phe, -(alphaMe)Val -(alphaMe)Leu. Chiral induction significantly lower isomeric Boc-Xaa*-Bip-OMe,...
The development of adenosine A2A receptor antagonists has received much interest in recent years for the treatment neurodegenerative diseases. Based on docking studies, a new series 2-arylbenzoxazoles been identified as potential A2AR antagonists. Structure-affinity relationship was investigated position 2, 5 and 6 benzoxazole heterocycle leading to compounds with micromolar affinity towards receptor. Compound F1, an 1 μm, presented good absorption, distribution, metabolism excretion...
Abstract A new set of β‐amino acids that carry various crown ether receptors on their side chains the general formula ( S )‐β 3 ‐HDOPA(crown ether) (HDOPA: homo‐3,4‐dihydroxyphenylalanine; (crown ether): [15]crown‐5 ([15‐C‐5]), [18]crown‐6 ([18‐C‐6]), [21]crown‐7 ([21‐C‐7]), 1,2‐Benzo‐[24]crown‐8 ([Benzo‐24‐C‐8]) and R )‐Binol‐[20]crown‐6 ([( )‐Binol‐20‐C‐6])) was prepared. Peptides are based these crowned combined with (1 ,2 ) ‐ ACHC (2‐aminocyclohexanecarboxylic acid), which is known to be...
The "Journées Franco-Belges de Pharmacochimie" is a recognized annual meeting in organic and medicinal chemistry known for the quality of scientific exchange conviviality. Young researchers were encouraged to present their work share ideas with senior scientists. Abstracts plenary lectures, oral communications, posters presented during are collected this report.