A5074688963- Vagus Nerve Stimulation Research
- Neuroscience and Neural Engineering
- EEG and Brain-Computer Interfaces
- Photoreceptor and optogenetics research
- Hearing Loss and Rehabilitation
- Photoacoustic and Ultrasonic Imaging
- Advanced Chemical Sensor Technologies
- Regulation of Appetite and Obesity
- Electrochemical Analysis and Applications
- Heart Rate Variability and Autonomic Control
- Sensor Technology and Measurement Systems
- Eating Disorders and Behaviors
- Neural dynamics and brain function
- Ear Surgery and Otitis Media
- Gastrointestinal motility and disorders
- Neurobiology and Insect Physiology Research
- Hearing, Cochlea, Tinnitus, Genetics
- Nicotinic Acetylcholine Receptors Study
- Neuroscience and Neuropharmacology Research
- Analytical Chemistry and Sensors
- Advanced Memory and Neural Computing
- Retinal Development and Disorders
- Tactile and Sensory Interactions
- Neurological disorders and treatments
Northwestern University
2024
Université Libre de Bruxelles
2019-2022
Objective.Finite element modelling has been widely used to understand the effect of stimulation on nerve fibres.Yet literature analysis spontaneous activity is much scarcer.In this study, we introduce a method based finite model, analyse with typical bipolar electrode recording setup, enabling identification spontaneously active fibres.We applied our vagus nerve, which plays key role in refractory epilepsy.Approach.We developed 3D model including dynamic action potential (AP) propagation,...
Vagus nerve stimulation (VNS) therapy is associated with laryngeal muscle activation and induces voice modifications, well-known side effects of the resulting from co-activation recurrent nerve. In this study, we describe non-invasive transcutaneous recording motor evoked potentials (LMEPs), which could serve as a biomarker effective individual titration in patients drug-resistant epilepsy. We recruited epileptic treated for at least 6 months VNS. Trains 600-1200 VNS pulses were delivered...
Objective.To design and implement a setup forex-vivooptical stimulation for exploring the effect of several key parameters (optical power pulse duration), activation features (threshold, spatial selectivity) recovery characteristics (repeated stimuli) in peripheral nerves.Approach.A nerve chamber allowing ex-vivo electrical optical was designed built. A 1470 nm light source chosen to stimulate nerve. photodiode module implemented synchronization channels.Main results. Compound neural action...
On-demand stimulation improves the efficacy of vagus nerve (VNS) in refractory epilepsy. The is main peripheral parasympathetic connection and seizures are known to exhibit autonomic symptoms. Therefore, we hypothesized that seizure detection possible through electroneurogram (VENG) recording. We developed a metric able measure abrupt changes amplitude frequency spontaneous action potentials. A classifier was trained using “leave-one-out” method on set 6 3 control recordings utilize VENG...
Objective.The vagus nerve is considered to play a key role in the circadian rhythm. Chronic continuous analysis of activity could contribute better understanding light-dark modulations. This paper presents spontaneous performed four rats.Approach.We analyzed electroneurogram (VENG) and electroencephalogram (EEG) over recording period 28 d. Spike heart rate estimation were derived from VENG, slow-wave was EEG. The presence repetitive patterns investigated with periodograms, cosinor fitting,...
Abstract The measurement of birefringence variations related to nerve activity is a promising label‐free technique for sensing compound neural action potentials (CNAPs). While widely applied in crustaceans, little known about its efficiency on mammal peripheral nerves. In this work, recordings detect CNAPs, and Stokes parameters measurements were performed rat lobster single‐trial detection crustaceans was achieved successfully, no optical signal detected rats, even after extensive filtering...
Infrared Neural Stimulation (INS) is a novel neuromodulation technique involving rapid temperature increase of the neuron membrane, resulting in action potential triggering. This paper describes an experimental setup developed to measure spatiotemporal gradients at surface ex vivo sciatic nerve. The also designed conduction velocity nervous fibers excited by INS, with aim determining type activated during optical stimulation. Two animal experiments successfully validated and provided...
Introduction Optical stimulation has been suggested for neural to improve cochlear implants. Light allows more spatially selective activation of neuron populations than electrical current, offering independent frequency bands along the spiral ganglion. These are available encode acoustic information with anticipated better resolution, improving implant user performance in noisy listening environments, tonal languages, and music perception. Methods implants (oCIs) can deliver light either...
Gastric electrical stimulation (GES) has been studied for decades as a promising treatment obesity. Stimulation pulses with fixed amplitude and pulse width are usually applied, but these have limitations regard to overcoming habituation GES inter-subject variation. This study aims analyze the efficacy of an adaptive protocol reducing food intake maintaining lean weight in dogs.Six beagle dogs were implanted remotely programmable gastric stimulator. An was designed increase energy...
<title>Abstract</title> Worldwide, thousands of patients with severe to profound hearing loss restore their cochlear implant devices. Newer developments in electrode design and manufacturing, as well a better understanding mechanics, allow for the conservation critical structures, which often translates into serviceable residual improve device performance. Monitoring insertion speed intraluminal pressure helps mitigate some these challenges. However, information becomes available after...
Introduction Worldwide, thousands of patients with severe to profound hearing loss restore their cochlear implant (CI) devices. Newer developments in electrode design and manufacturing a better understanding mechanics allow for conserving critical structures, often translating into serviceable residual improving device performance. Monitoring insertion speed intraluminal pressure helps mitigate some these challenges. However, the information becomes available after irreparable damage has...
Cochlear Implants (CIs) are considered one of the most successful neural prostheses. Today, more than 500,000 severely-to-profoundly deaf individuals have received a CI to restore some their hearing. However, performance individual users varies largely. While patients experience notable improvement in functional hearing, others receive little benefit from CIs. Some situations, such as noisy listening environments, tonal languages, and music perception, remain challenging for all users....