A5046528965- Neuroscience and Neural Engineering
- Vagus Nerve Stimulation Research
- EEG and Brain-Computer Interfaces
- Photoreceptor and optogenetics research
- Neurological disorders and treatments
- Neuroscience and Neuropharmacology Research
- Wireless Power Transfer Systems
- Advanced MRI Techniques and Applications
- Muscle activation and electromyography studies
- Pain Management and Treatment
- Advanced Battery Technologies Research
- Wireless Body Area Networks
- Heart Rate Variability and Autonomic Control
- Gastroesophageal reflux and treatments
- Electrochemical Analysis and Applications
- Sensor Technology and Measurement Systems
- Neurobiology and Insect Physiology Research
- Advanced Memory and Neural Computing
- Cardiac Arrhythmias and Treatments
- Laser Applications in Dentistry and Medicine
- Retinal Development and Disorders
- Analytical Chemistry and Sensors
- Advanced Chemical Sensor Technologies
- Congenital Heart Disease Studies
- Transcranial Magnetic Stimulation Studies
Synergia (United States)
2016
Despite the technological progress in robotics achieved last decades, prosthetic limbs still lack functionality, reliability, and comfort. Recently, an implanted neuromusculoskeletal interface built upon osseointegration was developed tested humans, namely Osseointegrated Human-Machine Gateway. Here, we present embedded system to exploit advantages of this technology. Our artificial limb controller allows for bioelectric signals acquisition, processing, decoding motor intent, control,...
Despite the proven efficacy of vagus nerve stimulation (VNS) in seizure control, its precise mechanism action remains unclear. VNS is known to impact cardiorespiratory system. In this study, we explored effects standard and breathing-synchronized on heart respiratory rates anesthetized epileptic rats, as well their susceptibility. Seizures were induced rats by intravenous pentylenetetrazol (PTZ) infusion. Three animal groups ( n = 4) subjected different types stimulation: Sham VNS, Standard...
Objective.Finite element modelling has been widely used to understand the effect of stimulation on nerve fibres.Yet literature analysis spontaneous activity is much scarcer.In this study, we introduce a method based finite model, analyse with typical bipolar electrode recording setup, enabling identification spontaneously active fibres.We applied our vagus nerve, which plays key role in refractory epilepsy.Approach.We developed 3D model including dynamic action potential (AP) propagation,...
This paper presents an implantable batteryless telemetric microsystem for EMG recording, based on a single 30 mm/sup 2/ high-voltage 2.5 /spl mu/m BiCMOS ASIC, which includes and two-channels recording circuits. It has been developed within the framework of European project, where this device is implanted in rabbits research studies related to control prosthesis through muscular biosignals. Power transferred with 10 MHz inductive link using efficient Class-E driver. Data transmitted...
Objective.To design and implement a setup forex-vivooptical stimulation for exploring the effect of several key parameters (optical power pulse duration), activation features (threshold, spatial selectivity) recovery characteristics (repeated stimuli) in peripheral nerves.Approach.A nerve chamber allowing ex-vivo electrical optical was designed built. A 1470 nm light source chosen to stimulate nerve. photodiode module implemented synchronization channels.Main results. Compound neural action...
Abstract A novel programmable implantable neurostimulation platform based on photonic power transfer has been developed for various clinical applications with the main focus of being safe to use MRI scanners. The wires usually conveying electrical current from neurostimulator electrodes are replaced by optical fibers. Photovoltaic cells at tip fibers convert laser light biphasic impulses together feedback signals 54% efficiency. Furthermore, a biocompatible, and ultra-flexible lead was...
On-demand stimulation improves the efficacy of vagus nerve (VNS) in refractory epilepsy. The is main peripheral parasympathetic connection and seizures are known to exhibit autonomic symptoms. Therefore, we hypothesized that seizure detection possible through electroneurogram (VENG) recording. We developed a metric able measure abrupt changes amplitude frequency spontaneous action potentials. A classifier was trained using “leave-one-out” method on set 6 3 control recordings utilize VENG...
The objective of the study was to record Laryngeal Motor Evoked Potentials (LMEPs) in Vagus Nerve Stimulation (VNS)-implanted patients suffering from Drug-Resistant Epilepsy (DRE). Based on these recordings, LMEPs characteristics were evaluated and compared between responders (R) non-responders (NR). Finally, possible under- or over-stimulation assessed based a physiological indicator fiber engagement. Mean dose–response curves R NR. A Support Vector Machine (SVM) model built both LMEP...
Objective.The vagus nerve is considered to play a key role in the circadian rhythm. Chronic continuous analysis of activity could contribute better understanding light-dark modulations. This paper presents spontaneous performed four rats.Approach.We analyzed electroneurogram (VENG) and electroencephalogram (EEG) over recording period 28 d. Spike heart rate estimation were derived from VENG, slow-wave was EEG. The presence repetitive patterns investigated with periodograms, cosinor fitting,...
Photonic stimulation is a new modality of nerve stimulation, which could overcome some the electrical limitations. In this paper, we present results photonic rodent sciatic with 1470 nm laser. Muscle activation was observed radiant exposure 0.084 J/cm<sup>2</sup>.
In the context of near-infrared neurostimulation, we report on an experimental hybrid electrode allowing for simultaneous photonic or electrical neurostimulation and recording evoked action potentials. The includes three contacts one optrode. optrode is opening in cuff through which tip optical fibre held close to epineurium. Two provide potential recording. remaining contact, together with a remote subcutaneous electrode, used electric stimulation allows periodical assessment viability...
Abstract The measurement of birefringence variations related to nerve activity is a promising label‐free technique for sensing compound neural action potentials (CNAPs). While widely applied in crustaceans, little known about its efficiency on mammal peripheral nerves. In this work, recordings detect CNAPs, and Stokes parameters measurements were performed rat lobster single‐trial detection crustaceans was achieved successfully, no optical signal detected rats, even after extensive filtering...
This work presents an automated analysis algorithm to detect action potentials (APs) in a nerve and quantify its activity. The is based on template matching. templates are automatically adapted individual AP shapes that vary depending the fibers from which originates, recording setup used. was validated by quantifying vagus activity recorded during vivo experiments rat model. MATLAB version of code available open access GitHub <sup xmlns:mml="http://www.w3.org/1998/Math/MathML"...
This work describes the fabrication of a lab-made cuff electrode intended for rat vagus nerve electroneurography. The is built around 50 µm platinum wires contacts in tripolar configuration, 4mm contact spacing. body made silicone rubber and four surgical threads. In vivo validation allowed to record respiration cardiac related activity from nerve. results show that our electrodes are suitable low-cost alternative preclinical studies.
Inductive powering of implantable medical devices involves numerous factors acting on the system efficiency and safety in adversarial ways. This paper lightens up their role identifies a procedure enabling design. The latter enables problem to be decoupled into four principal steps: frequency choice, magnetic link optimization, secondary circuit then finally primary designs. methodology has been tested for device requirering power 300mW implanted at distance 15 30mm from outside source. It...
Infrared Neural Stimulation (INS) is a novel neuromodulation technique involving rapid temperature increase of the neuron membrane, resulting in action potential triggering. This paper describes an experimental setup developed to measure spatiotemporal gradients at surface ex vivo sciatic nerve. The also designed conduction velocity nervous fibers excited by INS, with aim determining type activated during optical stimulation. Two animal experiments successfully validated and provided...
This work presents a setup for chronic monitoring of spontaneous epileptic seizures in rats under kainic acid. The system allows to record the vagus nerve electroneurogram at 40 kS/s and electroencephalogram 250 S/s using an USB-6212 multifunction I/O-device. includes video channel (20 fps) controlled by Raspberry Pi 4 Model B. A slipring rat move freely. Quick cage cleaning is possible through movable base. was tested on Wistar after status epilepticus induction, appears be robust reliable...