A5011145878- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Sleep and Wakefulness Research
- Neurological disorders and treatments
- Functional Brain Connectivity Studies
- Neuroscience and Neural Engineering
- Memory and Neural Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Fractal and DNA sequence analysis
- Photoreceptor and optogenetics research
- Transcranial Magnetic Stimulation Studies
- Complex Systems and Time Series Analysis
- Acute Ischemic Stroke Management
- Glioma Diagnosis and Treatment
- Time Series Analysis and Forecasting
- Meningioma and schwannoma management
- Cerebrovascular and Carotid Artery Diseases
- Point processes and geometric inequalities
- Botulinum Toxin and Related Neurological Disorders
- Pharmacological Effects and Toxicity Studies
- Restless Legs Syndrome Research
- Neural Networks and Applications
- Vascular Malformations Diagnosis and Treatment
Semmelweis University
2021-2025
National Institute of Menthal Health, Neurology and Neurosurgery - Nyírő Gyula Hospital
2024
Országos Idegsebészeti Tudományos Intézet
2014-2023
Pázmány Péter Catholic University
2007-2023
National Institute of Mental Health
2021-2023
Tampere University Hospital
2023
Hospital de Santa Maria
2023
Kempenhaeghe
2023
Tampere University
2023
Neuroscience Institute
2022
Ripples are high-frequency oscillation bursts in the mammalian hippocampus mainly present during Non-REM sleep. In rodents they occur association with sharp waves and grouped by cortical slow such that, parallel sleep spindles, ripple activity is suppressed hyperpolarized down-state enhanced depolarized up-state. The temporal coupling between oscillations, spindles ripples has been suggested to serve a hippocampo-neocortical dialogue underlying memory consolidation Here, we examined whether...
The electroencephalogram (EEG) is a mainstay of clinical neurology and tightly correlated with brain function, but the specific currents generating human EEG elements remain poorly specified because lack microphysiological recordings. largest event in healthy EEGs K-complex (KC), which occurs slow-wave sleep. Here, we show that KCs are generated widespread cortical areas by outward dendritic middle upper layers, accompanied decreased broadband power neuronal firing, demonstrate steep decline...
The alpha rhythm is the longest-studied brain oscillation and has been theorized to play a key role in cognition. Still, its physiology poorly understood. In this study, we used microelectrodes macroelectrodes surgical epilepsy patients measure intracortical thalamic generators of during quiet wakefulness. We first found that both visual somatosensory cortex propagates from higher-order lower-order areas. posterior cortex, anterosuperior areas toward occipital pole, whereas associative...
Brain electrical activity is largely composed of oscillations at characteristic frequencies. These rhythms are hierarchically organized and thought to perform important pathological physiological functions. The slow wave a fundamental cortical rhythm that emerges in deep non-rapid eye movement sleep. In animals, the modulates delta, theta, spindle, alpha, beta, gamma ripple oscillations, thus orchestrating brain While can enhance epileptic manifestations, it also underlie essential...
The efficacy of deep brain stimulation the anterior nucleus thalamus (ANT DBS) in patients with drug-resistant epilepsy (DRE) was demonstrated double-blind Stimulation Anterior Nucleus Thalamus for Epilepsy randomized controlled trial. Medtronic Registry (MORE) aims to understand safety and longer-term effectiveness ANT DBS therapy routine clinical practice.
Endocannabinoid signaling is a key regulator of synaptic neurotransmission throughout the brain. Compelling evidence shows that its perturbation leads to development epileptic seizures, thus indicating endocannabinoids play an intrinsic protective role in suppressing pathologic neuronal excitability. To elucidate whether long-term reorganization endocannabinoid occurs patients, we performed comparative expression profiling along with quantitative electron microscopic analysis control...
Abstract Sleep‐associated memory consolidation is thought to rely on coordinated information transfer between the hippocampus and neocortex brought about during slow wave sleep (SWS) by distinct local field potential oscillations. Specifically, findings in animals have led concept that ripples originating from combine with spindles provide a fine‐tuned temporal frame for persistent of memory‐related neocortex. The present study focused characterizing relationship parahippocampal ripple...
Calretinin is expressed mainly in interneurons that specialize to innervate either principal cell dendrites or other the human hippocampus. Calretinin-containing cells were shown be vulnerable animal models of ischaemia and epilepsy. In hippocampus, controversial data published regarding their sensitivity Therefore we aimed reveal fate this type epileptic hippocampi. Surgically removed hippocampi patients with drug-resistant temporal lobe (n = 44) examined compared control 8) samples...
The role of cortical connectivity in brain function and pathology is increasingly being recognized. While vivo magnetic resonance imaging studies have provided important insights into anatomical functional connectivity, these methodologies are limited their ability to detect electrophysiological activity the causal relationships that underlie effective connectivity. Here, we describe results cortico-cortical evoked potential (CCEP) mapping using single pulse electrical stimulation 25...
The neocortex is composed of six anatomically and physiologically specialized layers. It has been proposed that integration activity across cortical areas mediated by associative connections terminating in superficial layers, slow rhythms. However, the means through which neocortical anatomy physiology interact to coordinate neural remains obscure. Using laminar microelectrode arrays 19 human participants, we found most EEG below 10-Hz (delta/theta) generated layers during both wakefulness...
Abstract Sleep spindles are major oscillatory components of Non‐Rapid Eye Movement (NREM) sleep, reflecting hyperpolarization‐rebound sequences thalamocortical neurons. Reports suggest a link between sleep and several forms high‐frequency oscillations which considered as expressions pathological off‐line neural plasticity in the central nervous system. Here we investigated relationship thalamic ripples anterior mediodorsal nuclei (ANT MD) epilepsy patients. Whole‐night LFP from ANT MD were...
Abstract Hippocampal rhythmic slow activity (RSA) is a well‐known electrophysiological feature of exploratory behavior, spatial cognition, and rapid eye movement (REM) sleep in several mammalian species. Recently, RSA humans during navigation was reported, but systematic data regarding human REM are lacking. Using mesio‐temporal corticography with foramen ovale electrodes epileptic patients, we report the presence 1.5–3‐Hz synchronous hippocampal oscillation seemingly specific to sleep. This...
The dentate gyrus, the cornu ammonis 2 region and subiculum of human hippocampal formation are resistant to cell loss associated with temporal lobe epilepsy. subiculum, but not generates interictal-like activity in tissue slices from epileptic patients. In this study, we asked whether a similar population is generated examined electrophysiological neuroanatomical characteristics neurons that may be involved. Hippocampal were prepared postoperative derived Field potentials multi-unit recorded...
Summary The endocannabinoid system plays a central role in retrograde synaptic communication, and controls both glutamatergic γ‐aminobutyric acid (GABA)ergic transmission via type 1 cannabinoid (CB1) receptor. Both sclerotic human hippocampi the chronic phase of pilocarpine‐induced epilepsy mice with sclerosis, CB1‐receptor–positive interneuron somata were preserved dentate gyrus CA1 area, density CB1‐immunostained fibers increased considerably molecular layer. This suggests that, although...
Hyperexcitability and hypersynchrony of neuronal networks are thought to be linked the generation epileptic activity in both humans animal models. Here we show that human postoperative neocortical tissue is able generate two different types synchronies vitro. Epileptiform bursts occurred only slices derived from patients were hypersynchronous events characterized by high levels excitability. Spontaneous population emerged non-epileptic tissue, with a significantly lower degree excitability...
Sleep spindles are a cardinal feature in human NREM sleep and may be important for memory consolidation. We studied the intracortical organization of men women by recording spontaneous from different cortical layers using linear microelectrode arrays. Two patterns spindle generation were identified visual inspection, confirmed with factor analysis. Spindles (10–16 Hz) largest most common upper middle channels, limited involvement deep channels. Many observed only or but approximately half...
The surgical procedure for severe, drug-resistant, unilateral hemispheric epilepsy is challenging. Over the last decades landscape disconnection procedures changed from anatomical hemispherectomy to functional hemispherotomy with a reduction of complications and stable good seizure outcome. Here, task force European surgeons prepared, on behalf EANS Section Functional Neurosurgery, consensus statement different aspects procedure. To determine history, indication, timing, techniques, current...
Brain tumors are frequently diagnosed diseases in which etiology and progression largely depend on mutations genetic factors. Additionally, recent reports document that the microbiome may influence tumor growth, microenvironment, response to therapy. Our goal was examine extent bacterial composition—microbiota—and fungal composition—mycobiota—characteristic of its microenvironment correlate with composition gut blood microbiota mycobiota five randomly selected brain patients. The tumor,...
A large proportion of hippocampal afferents and efferents are relayed through the subiculum. It is also thought to be a key structure in generation maintenance epileptic activity; rhythmic interictal-like discharges were recorded previous studies subicular slices excised from temporal lobe epilepsy patients. In order investigate if how subiculum involved vivo, lateral electrical activity under anesthesia 11 drug-resistant patients undergoing lobectomy. Based on laminar field potential...
Abstract Knowledge about the activity of single neurons is essential in understanding mechanisms synchrony generation, and particularly interesting if related to pathological conditions. The generation interictal spikes—the hypersynchronous events between seizures—is linked hyperexcitability bursting behaviour animal models. To explore its cellular humans we investigated clustered a human vitro model generating both physiological epileptiform synchronous events. We show that non-epileptic...