A5086460918- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Neuroscience and Neural Engineering
- Barrier Structure and Function Studies
- Alzheimer's disease research and treatments
- Click Chemistry and Applications
- Photoreceptor and optogenetics research
- Memory and Neural Mechanisms
- Chemical Synthesis and Analysis
- Luminescence and Fluorescent Materials
- Epilepsy research and treatment
- Sleep and Wakefulness Research
- Computational Drug Discovery Methods
- Healthcare Systems and Public Health
- Neurological Disease Mechanisms and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Drug Transport and Resistance Mechanisms
- Advanced Fluorescence Microscopy Techniques
- Nicotinic Acetylcholine Receptors Study
- Biochemical and Structural Characterization
- Metabolomics and Mass Spectrometry Studies
- Advanced biosensing and bioanalysis techniques
- Conducting polymers and applications
- Molecular Sensors and Ion Detection
- Advanced Memory and Neural Computing
Institute of Cognitive Neuroscience and Psychology
2018-2024
HUN-REN Research Centre for Natural Sciences
2020-2023
Semmelweis University
2020-2023
Hungarian Research Network
2021-2022
Szent János Kórház
2015-2021
Hungarian Academy of Sciences
2018-2019
Decreased beta-amyloid clearance in Alzheimer's disease and increased blood-brain barrier permeability aged subjects have been reported several articles. However, morphological functional characterization of its membrane transporter activity not described physiological aging yet. The aim our study was to explore the structural changes brain microvessels possible alterations P-glycoprotein at with aging. Our approach included MR imaging for anatomical orientation middle rats,...
The use of SU-8 material in the production neural sensors has grown recently. Despite its widespread application, a detailed systematic quantitative analysis concerning biocompatibility central nervous system is lacking. In this immunohistochemical study, we quantified neuronal preservation and severity astrogliosis around devices implanted neocortex rats, after 2 months survival. We found that density neurons significantly decreased up to distance 20 μm from implant, with an averaged...
Abstract Knowledge about the activity of single neurons is essential in understanding mechanisms synchrony generation, and particularly interesting if related to pathological conditions. The generation interictal spikes—the hypersynchronous events between seizures—is linked hyperexcitability bursting behaviour animal models. To explore its cellular humans we investigated clustered a human vitro model generating both physiological epileptiform synchronous events. We show that non-epileptic...
Intrinsically disordered proteins (IDPs) play important roles in disease pathologies; however, their lack of defined stable 3D structures make traditional drug design strategies typically less effective against these targets. Based on promising results targeted covalent inhibitors (TCIs) challenging targets, we have developed a strategy targeting IDPs. As model system chose tau, an endogenous IDP the central nervous that is associated with severe neurodegenerative diseases via its...
A novel family of julolidine-containing fluorescent rhodols equipped with a wide variety substituents was synthesized in versatile two-step process. The prepared compounds were fully characterized and exhibited excellent fluorescence properties for microscopy imaging. best candidate conjugated to the therapeutic antibody trastuzumab through copper-free strain-promoted azide-alkyne click reaction. rhodol-labeled successfully applied vitro confocal two-photon imaging Her2+ cells.
Epilepsy is a prevalent neurological condition, with underlying neuronal mechanisms involving hyperexcitability and hypersynchrony. Imbalance between excitatory inhibitory circuits, as well histological reorganization are relatively well-documented in animal models or even the human hippocampus, but less known about neocortical epileptic activity. Our knowledge changes signaling especially scarce, compared to that cell population. This study investigated firing properties of single neurons...
Key points Initiation of pathological synchronous events such as epileptic spikes and seizures is linked to the hyperexcitability neuronal network in both humans animals. In present study, we show that epileptiform interictal‐like emerged human neocortical slices by blocking GABA A receptors, following disappearance spontaneously occurring population activity. Large variability temporally spatially simple complex was generated tissue from patients, whereas only appeared samples non‐epileptic...
The first representatives of fluorescent boro-β-carbolines were applied for labeling trastuzumab. antibody fluorophore conjugate was confirmed as a useful tool and imaging tumour cells in confocal two-photon microscopy.
An asymmetric cyanine-type fluorescent dye was designed and synthesized via a versatile, multi-step process, aiming to conjugate with an Her2+ receptor specific antibody by azide-alkyne click reaction. The aromaticity the excitation relaxation energetics of fluorophore were characterized computational methods. exhibited excellent fluorescence properties for confocal microscopy, offering efficient applicability in vitro imaging due its merits such as high molar absorption coefficient (36 816...
Abstract Infrared (IR) neuromodulation holds an increasing potential in brain research, which is fueled by novel neuroengineering approaches facilitating the exploration of biophysical mechanism microscale. The group lays down fundamentals spatially controlled optical manipulation inherently temperature‐sensitive neuronal populations. concept and vivo validation a multifunctional, stimulation microdevice presented, expands capabilities conventional optrodes coupling IR light through...
Inhibitory neurons innervating the perisomatic region of cortical excitatory principal cells are known to control emergence several physiological and pathological synchronous events, including epileptic interictal spikes. In humans, little is about their role in synchrony generation, although changes epilepsy have been thoroughly investigated. This paper demonstraits how parvalbumin (PV)- type 1 cannabinoid receptor (CB1R)-positive interneurons innervate pyramidal cell bodies, population...