A5100405560- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Parkinson's Disease Mechanisms and Treatments
- Cardiovascular Health and Disease Prevention
- Cancer Mechanisms and Therapy
- Cancer, Lipids, and Metabolism
- Neurological disorders and treatments
- Liver Disease and Transplantation
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Blood Pressure and Hypertension Studies
- Lung Cancer Treatments and Mutations
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Lung Cancer Diagnosis and Treatment
- Cardiovascular Disease and Adiposity
- Multiple Myeloma Research and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Function and Risk Factors
- Phytochemicals and Antioxidant Activities
- Organ Transplantation Techniques and Outcomes
- X-ray Diffraction in Crystallography
- Pregnancy and preeclampsia studies
- Neurological Disease Mechanisms and Treatments
- Crystallization and Solubility Studies
Peking University
2015-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2024
First Affiliated Hospital of Xiamen University
2024
Peking University First Hospital
2015-2024
China Medical University
2013-2024
AbbVie (United States)
2016-2024
Collaborative Innovation Center of Chemistry for Energy Materials
2024
Fudan University
2022-2024
Hubei University of Medicine
2024
Shaanxi Provincial People's Hospital
2024
Foslevodopa/foscarbidopa, a soluble formulation of levodopa/carbidopa (LD/CD) prodrugs for the treatment Parkinson's disease (PD), is administered as 24-hour/day continuous subcutaneous infusion (CSCI) with single site. The efficacy and safety foslevodopa/foscarbidopa versus oral immediate-release LD/CD was previously demonstrated in patients PD 12-week, randomized, double-blind, phase 3 trial (NCT04380142). We report results separate 52-week, open-label, registrational (NCT03781167) that...
As Parkinson's disease (PD) advances, management is challenged by an increasingly variable and inconsistent response to oral dopaminergic therapy, requiring special considerations the provider. Continuous 24 h/day subcutaneous infusion of foslevodopa/foscarbidopa (LDp/CDp) provides steady stimulation that can reduce symptom fluctuation. Our aim review initiation, optimization, maintenance LDp/CDp identify possible challenges, share potential mitigations. Review available clinical trial data...
Reduced risk and severity of stroke in adult females is thought to depend on normal endogenous levels estrogen, a well-known neuroprotectant immunomodulator. In male mice, experimental induces immunosuppression the peripheral immune system, characterized by reduction spleen size cell numbers decreased cytokine chemokine expression. However, stroke-induced has not been evaluated female mice. To test hypothesis that estradiol (E2) deficiency exacerbates after focal females, we effect middle...
In the present article, a flavonoid was separated and purified from celery leaf through ethanol extraction, column chromatography crystallization. The product identified as apiin by LC/ESI-MS, its antioxidant activities were evaluated in vitro, including 1,1-diphenl-2-picrylhyrazyl free radical (DPPH˙), superoxide (O2−˙) hydroxyl (OH˙) scavenging assays. IC50 values 68.0 μg ml−1 DPPH assay, 0.39 mg O2−˙ assay 48.0 OH˙ assay. investigated vivo with use of mice models. All data measured...
This study aimed to investigate the association of noninvasive central aortic blood pressure with kidney function decline in a Chinese community-based population normal at baseline. A total 3153 participants from an atherosclerosis cohort were included our analysis. The primary outcome was renal defined as drop estimated glomerular filtration rate (eGFR) category accompanied by ≥25% eGFR baseline; or sustained >5 mL/min per 1.73 m(2)/y. secondary outcomes rapid (a >3 m(2)/y) and new...
Previous studies established a possible link among hyperhomocysteinemia (HHcy), dyslipidemia, and atherosclerosis. However, there was limited epidemic data concerning the relation between HHcy lipid profiles, especially in community-based Chinese populations. This study aim to investigate association of plasma homocysteine (Hcy) level with profiles population without lipid-lowering treatment. A total 4660 subjects from cohort Shijingshan district Beijing were included analysis. Plasma Hcy,...
Atom transfer radical addition and Heck-type reaction between alkenes ethyl iododifluoroacetate by using organophosphine compounds as catalysts have been developed. The proceeds under mild conditions with excellent functional group tolerance high chemo- regioselectivities. Mechanistic study indicates that the might be initiated via noncovalent interactions an catalyst a carbon–iodine bond.
Levodopa-carbidopa intestinal gel (LCIG) improves motor and non-motor symptoms in patients with advanced Parkinson's disease (aPD).To present the final 36-month efficacy safety results from DUOGLOBE (DUOdopa/Duopa Patients Advanced Disease - a GLobal OBservational Study Evaluating Long-Term Effectiveness; NCT02611713).DUOGLOBE was an international, prospective, long-term, real-world, observational study of aPD initiating LCIG routine clinical care. The primary endpoint change...
Abstract Background Atherogenic index of plasma (AIP) has been reported as a critical predictor on the risks and clinical outcomes cardiovascular diseases (CVDs), we aimed to explore potential predictive value cumulative AIP major adverse cardiac events (MACE), stroke, myocardial infarction (MI) mortality. Methods A large-scale community-based prospective cohort was established from December 2011 April 2012 followed up in May July 2014. The endpoint were obtained before 31, 2021. calculated...
Abstract Background Foslevodopa/foscarbidopa is a subcutaneous infusion of levodopa/carbidopa prodrugs. Objectives Assess correlations between sleep and efficacy from interim data phase 3 trial foslevodopa/foscarbidopa (NCT03781167). Methods Pearson (Parkinson's Disease Sleep Scale‐2 [PDSS‐2]) quality life (QoL; Parkinson's Questionnaire‐39), motor experiences daily living (m‐EDL; Movement Disorder Society‐Unified Scale Part II), “Off”/“On” times were calculated for baseline week 26...
Sepsis-induced acute kidney injury (AKI) represents a major cause of mortality in intensive care units. Sivelestat, selective inhibitor neutrophil elastase (NE), can attenuate sepsis-related lung injury. However, whether sivelestat preserve function during sepsis remains unclear. In this study, we thus examined the effects on AKI. Cecal ligation and puncture (CLP) was performed to induce multiple bacterial infection male Sprague-Dawley rats, subsequently, 50 or 100 mg/kg were administered by...
Abstract This retrospective cohort study aimed to evaluate the prognostic value of alpha-fetoprotein (AFP) response in advanced-stage hepatocellular carcinoma (HCC) patients treated with sorafenib combined transarterial chemoembolization. From May 2008 July 2012, 118 HCC baseline AFP levels >20 ng/ml combination therapy were enrolled. A receiver operating characteristic curve was used generate a cutoff point for changes predicting survival. The defined as an decrease rate [ΔAFP(%)]...
Alpha-lipoic acid (ALA) reportedly has protective effects against sepsis, which is a leading cause of mortality worldwide and associated with multiple organ dysfunction. The present study aimed to investigate further the possible action mechanisms ALA. Male Sprague-Dawley rats were subjected cecal ligation puncture (CLP) in order establish sepsis model. received an oral gavage 200 mg/kg ALA or saline immediately after surgery. heart rate (HR), left ventricular systolic pressure (LVSP),...
<b><i>Objective:</i></b> We aimed to investigate the relationships of body mass index (BMI), waist circumference (WC), and obesity defined using a combination both indexes, with incidence hypertension in Chinese community-based population. <b><i>Methods:</i></b> A total 1,927 participants (57.2 ± 8.9 years old) normal blood pressure at baseline were recruited from Shijingshan community Beijing. Incident was as ≥140/90 mm Hg, self-reported...
Abstract Immunological tolerance is critical for maintaining gut homeostasis. An imbalance between interleukin-17 (IL-17)-producing T helper 17 (T H 17) cells and regulatory reg cells) involved in ulcerative colitis (UC) pathogenesis. Dendritic (DCs) are able to induce cell differentiation. Paeoniflorin (PF) a monoterpene glucoside that commonly used treatment of autoimmune disease. However, the immunological mechanism PF involvement UC unclear. The present study aimed explore whether can...