A5055400677- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Cerebrovascular and Carotid Artery Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Peripheral Artery Disease Management
- Heart Rate Variability and Autonomic Control
- Retinal Imaging and Analysis
- Nutritional Studies and Diet
- Atherosclerosis and Cardiovascular Diseases
- Chronic Kidney Disease and Diabetes
- Retinal and Optic Conditions
- Inflammatory mediators and NSAID effects
- Folate and B Vitamins Research
- Galectins and Cancer Biology
- Heart rate and cardiovascular health
- Inflammatory Biomarkers in Disease Prognosis
- Cardiovascular Health and Risk Factors
- Glaucoma and retinal disorders
- Antiplatelet Therapy and Cardiovascular Diseases
- Peptidase Inhibition and Analysis
- Lipoproteins and Cardiovascular Health
- Liver Disease Diagnosis and Treatment
- Diabetes Treatment and Management
- Diabetes and associated disorders
- Atrial Fibrillation Management and Outcomes
Peking University First Hospital
2016-2025
Peking University
2016-2025
Creative Commons
2017
Noonan syndrome with multiple lentigines (NSML) is a rare autosomal dominant disorder, primarily caused by variants in the PTPN11 gene. Characterized lentigines, hypertelorism, short stature, and hearing loss, its common cardiac manifestations include pulmonary stenosis, hypertrophic cardiomyopathy (HCM), atrial septal defect, left-sided heart lesions. We report 58-year-old female diagnosed NSML presenting bilateral ventricular chamber enlargement fibrillation, which are uncommon phenotypes of NSML.
ABSTRACT To investigate whether retinal arterial narrowing is associated with incident carotid plaque in the general population. Individuals without 2014 who developed new‐onset 2018 were selected as cases ( n = 156) for atherosclerosis group and matched age sex a ratio of 1:1 control group. The effects baseline central arteriolar equivalent (CRAE), venular (CRVE), arteriovenous (AVR) on risk evaluated multivariable conditional logistic regression models. Subgroup analyses performed. mean...
As a surrogate of arterial stiffness, the brachial-ankle pulse wave velocity (baPWV) is good predictor incident cardiovascular disease. Remnant cholesterol (RC) proven independent risk factor for However, relationship between RC and baPWV unknown. The present study was performed to explore this relationship.Cross-sectional study.This involved 8,028 participants community-based atherosclerosis cohort from China. Community residents aged ≥40 years were enrolled by responding detailed research...
Abstract Accumulated evidence has shown that carotid‐femoral and brachial‐ankle PWV well predict cardiovascular events but it is still unclear if the predictability same or not. In this cross‐sectional study based on a community atherosclerosis cohort in Beijing, China, total of 5282 participants without previous coronary heart disease stroke were enrolled from China. The 10‐year atherosclerotic (ASCVD) risk calculated by China‐PAR model, < 5%, 5%–10% > 10% defined as low,...
Abstract Carotid‐femoral pulse wave velocity (cfPWV) and brachial‐ankle (baPWV) act as two most frequently applied indicators to evaluate arterial stiffness. Limited studies have systematically compared the relationships between cfPWV/baPWV increased carotid intima‐media thickness (cIMT). This study aimed investigate associations of PWV indices with cIMT in a Chinese community‐based population. A total 6026 participants from an atherosclerosis cohort were included our analysis. Increased was...
Remnant lipoprotein cholesterol (RC) is an independent risk factor for cardiovascular disease (CVD). However, the relationships of remnant and other conventional lipid parameters with new-onset carotid plaque are not fully understood in Chinese community-based population.A total 872 plaque-free participants (51.39 ± 4.96 years old) no history CVD were included this study. The plasma concentrations RC calculated by subtracting low-density (LDL-C) high-density (HDL-C) from (TC). Multivariate...
Hyperhomocysteinemia is an independent risk factor for cardio- and cerebrovascular diseases. However, the relationship between plasma homocysteine (Hcy) concentration peripheral arterial disease (PAD) has not been completely characterized. The aim of present study was to determine Hcy new-onset PAD assess effects combinations traditional cardiovascular factors.We conducted a prospective community-based cohort 3119 Chinese participants who did have at baseline, with median follow-up period...
To develop a highly efficient and fully automated method that measures retinal vessel caliber using digital photographs evaluate the association between hypertension.
Central blood pressure level is not always consistent with peripheral level, and especially their joint effect on incident hypertension well established. A total of 1607 non-hypertensive subjects from an atherosclerosis cohort in Beijing, China were included. systolic (cSBP) was obtained using Omron HEM-9000AI machine (pSBP) measured HEM-7117 electronic sphygmomanometer, separately. Hypertension defined as BP ≥ 140/90 mmHg or self-reported taking any antihypertension drugs at the follow-up...
Purpose: This study aimed to determine the relationship between metabolic syndrome (MetS) and rapid estimated glomerular filtration rate (eGFR) decline in a Chinese community-based population. Patients methods: A total of 3108 participants were recruited December 2011 July 2014 from an observational cohort designed for atherosclerotic diseases Beijing, China. The outcome was eGFR decline. Subgroup interaction analyses performed with respect number covariates. Results: Over median follow-up...
Abstract Purpose Arterial stiffness is important in the development of albuminuria. The brachial–ankle pulse wave velocity (baPWV) acts as an indicator arterial and may be associated with cardiovascular disease morbidity mortality. urine albumin-to-creatinine ratio (UACR) a metric used to diagnose albuminuria has also been shown disease. Here, we aim elucidate relationship between baPWV UACR Chinese community. Methods A community-based cohort 3669 subjects was selected for analysis. BaPWV...
Abstract Pulse wave velocity (PWV) is the most widely used measurement of arterial stiffness in clinical practice. This study aimed to evaluate and compare relationships between carotid‐femoral pulse (cfPWV) brachial‐ankle PWV (baPWV) presence carotid plaque. was designed cross‐sectionally included 6027 participants from a community‐based cohort Beijing. Logistic regression analyses were performed associations cfPWV baPWV with The mean (SD) 8.55 ± 1.83 16.79 3.36, respectively. prevalence...
Brachial-ankle pulse wave velocity (baPWV) was proven to be a prognostic indicator of cardiovascular events. However, the modifying effect blood pressure (BP) on longitudinal association between baPWV and new-onset hypertension is not well established. This study included 1849 non-hypertensive Chinese subjects from Shougang cohort during December 2011 July 2014. BaPWV obtained using an Omron Colin BP-203RPE III device. Multivariate logistic regression models were used evaluate associations...
Objective: To observe the association of carotid artery plaque with all-cause mortality and cardiovascular events. Methods: A total 7 017 participants who completed sonography examination between 2010 2011 were selected from stroke elderly prospective cohort Kailuan study. The received health 2006 2007, 2011. All divided into group (3 285 cases) without 732 according to or plaque.The events compared 2 groups. Multivariate Cox regression analysis was used identify Results: (1) There 4 297...
Background and Purpose DT‐678 is a novel antiplatelet prodrug, capable of releasing the active metabolite clopidogrel (AM) upon exposure to glutathione. In this study, we investigated factors responsible for high on‐treatment platelet reactivity (HTPR) in acute coronary syndrome (ACS) patients evaluated capacity overcome HTPR. Experimental Approach A total 300 consecutive ACS naive P2Y 12 receptor inhibitors were recruited genotyped CYP2C19 alleles. Blood samples drawn before after...
ABSTRACT Spot central and peripheral blood pressure are predictors for future hypertension, but the associations between or systolic (SBP) changes new‐onset hypertension unclear. Annual in SBP over a mean interval of 2.36 years were calculated 815 Chinese community residents without cardiovascular disease at first two visits, with formula: ([2 nd SBP−1 st SBP]/1 SBP) × 100%/time (years). The independent joint these third visit assessed multivariable logistic regression models. During...
Abstract Background Studies on the association between retinal vascular diameter and tortuosity risk of new-onset cardiovascular disease (CVD) are controversial. The predictive value parameters, measured through artificial intelligence (AI), for incident CVD in community population, remains to be explored. Objectives Our study aims investigate parameters (diameter tortuosity) AI, Chinese community-based population. Methods We conducted a prospective cohort subjects from Beijing China who...
Objectives To determine the relationship between depressive symptoms and progression of carotid intima–media thickness (cIMT) in a Beijing community-based population. Design Prospective cohort study 2014 2018. Setting Dwellers without cardiovascular disease, hypertension or diabetes from community. Participants 3849 Chinese community-dwelling individuals who underwent baseline screening for were invited to participate follow-up visit Among them, 2124 participants completed ultrasound...
Cardiovascular risk and related medical burden due to influenza in patients with chronic disease were higher than those of healthy subjects. As a result, vaccination is recommended as strategy for secondary prevention cardiovascular by major organizations, but the prevalence these population still low. Whether vaccine can prevent events such myocardial infarction death controversial based on current evidences from observational studies case-control studies, which may result study...