A5088102509- Migraine and Headache Studies
- Agriculture and Biological Studies
- Agricultural Productivity and Crop Improvement
- Neurological Disorders and Treatments
- Seed and Plant Biochemistry
- Trigeminal Neuralgia and Treatments
- Sympathectomy and Hyperhidrosis Treatments
- Magnetic and Electromagnetic Effects
- Agriculture, Plant Science, Crop Management
- Agricultural Development and Policies
- Olfactory and Sensory Function Studies
- Neuroscience of respiration and sleep
- Medical and Biological Sciences
- Parkinson's Disease Mechanisms and Treatments
- Peripheral Neuropathies and Disorders
- Botulinum Toxin and Related Neurological Disorders
- Wheat and Barley Genetics and Pathology
- Food Industry and Aquatic Biology
- Biochemical effects in animals
- Neurological disorders and treatments
- Fusion and Plasma Physics Studies
- Soil and Environmental Studies
- Human Health and Disease
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Parathyroid Disorders and Treatments
First Pavlov State Medical University of St. Petersburg
2016-2025
Orel State Agrarian University
2016-2023
ITMO University
2016-2017
EVRAZ (Canada)
2014
Institute of Pharmacology
2011
Foslevodopa/foscarbidopa, a soluble formulation of levodopa/carbidopa (LD/CD) prodrugs for the treatment Parkinson's disease (PD), is administered as 24-hour/day continuous subcutaneous infusion (CSCI) with single site. The efficacy and safety foslevodopa/foscarbidopa versus oral immediate-release LD/CD was previously demonstrated in patients PD 12-week, randomized, double-blind, phase 3 trial (NCT04380142). We report results separate 52-week, open-label, registrational (NCT03781167) that...
The Russian experts’ guidelines on evaluation and treatment of medication-overuse headache are based evidence-based medicine, the latest revision International Classification Headache Disorders. Basic information about epidemiology, risk factors, pathophysiological mechanisms, evaluation, most effective pharmacological drug non-pharmacological approaches to managing patients with presented.
Migraine is one of the most common types headache, which can lead to a significant decrease in quality life. Researchers identify migraine with aura, without and chronic that substantially reduces ability patients work frequently concurrent mental disorders drug-induced headache. The complications include status migrainosus, persistent aura infarction, migrainous infarction (stroke), aura-induced seizure. diagnosis based on complaints, past medical history, objective examination data,...
Migraine is a chronic neurological disorder that associated with considerable disadaptive effect on patients. Despite the development of pharmacotherapy strategies for migraine, only one third patients are satisfied their overall treatment. Many migraine turn to complementary and alternative medicine (CAM), which not usually considered part conventional always evidence-based. In practise, however, they often used improve effectiveness standard therapy or provide addition, in CAM methods,...
Chronic imflammatory demyelinating polyneuropathy (CIPD) is a heterogenous group of disimmune polyneuropathies, characterised by progressive or relapsing-remitting disease course, with electrophysiologically and pathomorphologically detected peripheral nerve demyelination. Immunotherapy considered reasonable in CIDP. CIDP associated antibodies against nodo-paranodal proteins, namely, NF155, CNTN1, Contactin protein has been described amongst the rare atypical subtypes. The detection proteins...
Objective. To present the recommendations of expert council Russian Society for Study Pain on “Dorsumio” drug in treatment chronic nonspecific back pain (CNBP). Key points. Currently, CNBP is leading disease associated with disability worldwide. Patients often experience concomitant depressive and anxiety symptoms complicating course therapy, as well worsening quality life working capacity. Various problems care include not only impact pathogenesis pain, but also depression, anxiety,...
On November 08, 2024 in Moscow, under the auspices of Russian Society for Study Pain (RSSP), a Council Experts was held, during which leading specialists field neurology, who have high level expertise treatment back pain, discussed modern approaches to therapy discogenic lumbosacral radiculopathy (DLSR). The actualized pathogenetic mechanisms disease onset and progression; pathogenesis, are currently still insufficiently affected by pharmacotherapeutic intervention. Conservative DLSR is...
On December 24, 2022, in Moscow an interdisciplinary Council of Headache Experts, held under the auspice interregional public organization “Russian Society for Study Headache”, discussed key problems effective treatment a migraine attack and possibilities specific drug Kaporiza® (rizatriptan). Despite development strategies relief attacks effectiveness triptans as first-line therapy, choice accordance with individual clinical profile patient is difficult due to existence drugs various forms...
The autonomous cardiovascular control can contribute to progression of migraine. However, current data on reactivity in migraine, especially severe forms, are essentially contradictory. main aim this study was compare the regulation circulation patients with episodic and chronic migraine healthy subjects. Seventy three (mean age 35 ± 10) including (51 patients, 4–14 headache days/months) (22 ≥15 days/month) along age-match (71 voluntaries) were examined. autonomic examined tilt-table test, a...
These recommendations on the diagnosis and treatment of migraine were elaborated by Russian headache experts in accordance with evidence-based practice. Together latest classification, diagnostic principles criteria different clinical sub-forms consensus contains basic data epidemiology, pathophysiological mechanisms, differential most effective evidence based approaches to pharmacological non-pharmacological management patients.Представленные рекомендации по диагностике и лечению мигрени...
This consensus reviewed the main current issues of clinical application and integration into everyday practice a new targeted preventive therapy for migraine using monoclonal antibodies (mAbs) to calcitonin gene related peptide (CGRP) ligand or receptor. These recommendations are based on scientific studies an analysis results several years use. The purpose is assist practitioners in prescribing effective prophylactic treatment anti-CGRP mAbs improve care patients with various forms disease.
The non-invasive biomarkers of migraine can help to develop the personalized medication this disorder. In testing antimigraine drugs capsaicin-induced skin redness with activated TRPV1 receptors in sensory neurons associated release mediator CGRP has already been widely used.Fourteen patients (mean age 34.6 ± 10.2 years) and 14 healthy volunteers 29.9 9.7 participated experiment. A new arrangement imaging photoplethysmography recently developed by us was used here discover novel sensitive...
Depression is one of the most common medical causes disability and mortality in patients all ages. Depressive disorders are practice physicians a variety specialties, including psychiatrists, neurologists, physicians. This paper provides summary review literature on modern ideas about epidemiology, classification, clinical picture depression. Current approaches to diagnosis treatment depressive neurological psychiatric discussed. Modern pharmacotherapeutic strategies for depression various...
The resolution of the expert council is devoted to discussing aspects use ipidacrine for treatment mononeuropathies, polyneuropathies and radiculopathies various etiologies. Specialists prepared recommendations ipidacrine's application in treating peripheral nervous system disorders.
Migraine is the second leading cause of maladjustment, and burden migraine determined by its impact on work ability, social activity family relationships. Objective: to identify patterns behavior Russian patients with migraine, factors affecting their quality life, level awareness disease based a semantic analysis messages in Web 2.0. Patients methods. The study results processing (automated natural language texts, taking into account meaning) anonymized from 6566 unique authors (patients...
Представлен обзор сведений литературы и клиническое наблюдение с не Val30Met-транстиретиновой амилоидной кардиомиопатией. Обсуждены алгоритмы диагностики врачебной тактике на современном этапе.
Relevance. The absence of a registered vaccine against G145R escape mutant determines the need to develop drug for prophylaxis infectious hepatitis caused by B virus. aim study was evaluate safety and reactogenicity new recombinant Bubo®-Unigep yeast in healthy volunteers. Materials & Methods. To confirm trivalent vaccine, an open, single- center, nonrandomized clinical trial conducted male volunteers at base «Uromed» (Smolensk) according protocol developed contract research organization...