A5078153847- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Cerebral Palsy and Movement Disorders
- Autoimmune Neurological Disorders and Treatments
- Stroke Rehabilitation and Recovery
- Autism Spectrum Disorder Research
- Neurological and metabolic disorders
- Telemedicine and Telehealth Implementation
- Biomedical Ethics and Regulation
- Genetics and Neurodevelopmental Disorders
- Botulinum Toxin and Related Neurological Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Lysosomal Storage Disorders Research
- Vascular Malformations Diagnosis and Treatment
- Ethics in Clinical Research
- Neurosurgical Procedures and Complications
- Neuroscience and Neural Engineering
- Healthcare Systems and Technology
- Intracerebral and Subarachnoid Hemorrhage Research
- Radiology practices and education
- Neuroscience and Neuropharmacology Research
- Balance, Gait, and Falls Prevention
- Metal-Organic Frameworks: Synthesis and Applications
- Amyotrophic Lateral Sclerosis Research
University of Illinois Chicago
2025
Rush University Medical Center
2020-2024
American Physical Therapy Association
2024
Rush University
2019-2023
International Neuromodulation Society
2019
University of California, San Francisco
2017-2018
Northwestern University
2007-2017
Glenbrook Hospital
2012
Objective This study was undertaken to compare the rate of change in cognition between glucocerebrosidase ( GBA ) mutation carriers and noncarriers with without subthalamic nucleus deep brain stimulation (STN‐DBS) Parkinson disease. Methods Clinical genetic data from 12 datasets were examined. Global assessed using Mattis Dementia Rating Scale (MDRS). Subjects examined for mutations categorized as or DBS +DBS+, +DBS‐), ‐DBS+, ‐DBS‐). subcategorized according severity (risk variant, mild,...
Estimates of the spectrum and frequency pathogenic variants in Parkinson's disease (PD) different populations are currently limited biased. Furthermore, although therapeutic modification several genetic targets has reached clinical trial stage, a major obstacle conducting these trials is that PD patients largely unaware their status and, therefore, cannot be recruited. Expanding number investigated PD-related genes including related to disorders with overlapping features large,...
Despite evidence for the benefits of exercise in Parkinson's disease (PD), many patients remain sedentary undefined reasons.To compare habits, perceptions about exercise, and barriers to 'low' (<3 h/week) 'high' (≥3 exercisers with PD.A 48-item survey was administered PD at an outpatient academic center. Chi-squared tests were used percentage differences between low- high-exercisers two-sided a significant level 0.05.243 surveys collected over three months; 28 excluded due incomplete data,...
Telemedicine is rapidly becoming a major vehicle of delivering neurologic care to patients who have limited access subspecialists and exaggerated travel hardship. However, neurology residents receive little no training in telemedicine outpatient clinics.We piloted, our knowledge, the first formalized, experiential teleneurology curriculum. Neurology their third fourth postgraduate years (PGY3 PGY4) at University California San Francisco completed an interactive lecture 4 weeks clinics...
Advanced diffusion imaging which accounts for complex tissue properties, such as crossing fibers and extracellular fluid, may detect longitudinal changes in widespread pathology atypical Parkinsonian syndromes. We implemented fixel-based analysis, Neurite Orientation Density Imaging (NODDI), free-water Parkinson's disease (PD), multiple system atrophy (MSAp), progressive supranuclear palsy (PSP), controls longitudinally over one year. Further, we used these three advanced techniques to...
Abstract Background To date, no medication has slowed the progression of Parkinson’s disease (PD). Preclinical, epidemiological, and experimental data on humans all support many benefits endurance exercise among persons with PD. The key question is whether there a definitive additional benefit exercising at high intensity, in terms slowing progression, beyond well-documented training treadmill for fitness, gait, functional mobility. This study will determine efficacy high-intensity as...
Abstract The formation of coordination polymers by the reaction [bis(catechol)salen]Mn III with several di‐ and trivalent metal ions is reported. These are insoluble in a wide range organic solvents water but can be dissolved upon addition excess pyrocatechol. They function as enantioselective heterogeneous epoxidation catalysts exhibit catalytic activity comparable to that homogeneous[bis(catechol)salen]Mn building block alone when used for 2,2‐dimethyl‐2 H ‐chromene. After catalysis,...
Falls in a person with Parkinson disease (PwP) are frequent, consequential, and only partially prevented by current therapeutic options. Notably, most falls PwPs occur the home or its immediate surroundings; however, our strategies for fall prevention clinic-centered. The primary objective of this nonrandomized pilot trial was to investigate feasibility preliminary efficacy novel implementation home-based PD telerehabilitation (tele-physical/occupational therapy) focusing on risk reduction...
Abstract Objective Mutations in the glucocerebrosidase ( GBA1 ) gene and subthalamic nucleus deep brain stimulation (STN‐DBS) are independently associated with cognitive dysfunction persons Parkinson's disease (PwP). We hypothesized that PwP both mutations STN‐DBS at greater risk of than only or STN‐DBS, neither. In this study, we determined pattern based on mutation status treatment. Methods who carriers without DBS +DBS+, +DBS−), noncarriers −DBS+, −DBS−) were included. Using NIH Toolbox,...
A 30-year-old previously healthy, right-handed woman was admitted to an outside hospital for new-onset seizures preceded by a flu-like prodrome week. After admission, she noted have frequent events consisting of sudden blank stare with associated hand fumbling, lip smacking, and
Despite data supporting the rapid adoption of telehealth in delivery clinical care North America, implementation visits research studies has faced critical barriers. These challenges include: (1) variations state licensure requirements for telehealth; (2) disparities access to among disadvantaged populations; (3) lack consistency individual Investigational Review Boards (IRBs). Each barrier prevents systematic conversion protocols include visits. The Parkinson's Foundation and members...
Falls are inherent to Parkinson's disease (PD) progression, and risk assessment is mandatory for optimal long term management. To determine if the telehealth application of two observer-based, objective measures fall-risk in PD-Five-Times-Sit-To-Stand (FTSTS) 360° Rapid-Turns-Test (RTT)-is feasible safe. Following in-clinic training, 15 people with Hoehn Yahr Stage 2 (n = 8) 3 7) PD, median MoCA score 25 (range 14-29), subjective freezing-of-gait 13), participated four televisits care...
Deep brain stimulation (DBS) is an effective and standard-of-care therapy for Parkinson's Disease other movement disorders when symptoms are inadequately controlled with conventional medications. It requires expert care patient selection, surgical targeting, titration. Despite the known benefits, racial/ethnic disparities in access have been reported. Technological advancements smartphone-enabled devices may influence racial disparities. Real-world evidence investigations can shed further...
Introduction: Up to 27% of individuals undergoing subthalamic nucleus deep brain stimulation (STN-DBS) have a genetic form Parkinson's disease (PD). G lucocerebrosidase ( GBA ) mutation carriers, compared sporadic PD, present with more aggressive disease, less asymmetry, and fare worse on cognitive outcomes STN-DBS. Evaluating STN intra-operative local field potentials provide the opportunity assess compare symmetry between non- carriers PD; thus, providing insight into genotype physiology,...
In the correct context, GAD65 antibody-associated neurologic disease should be included in differential diagnosis for parkinsonism, even hemiparkinsonism, especially setting of an acute-to-subacute presentation and emergence more prototypic features such as appendicular truncal muscle stiffness cerebellar ataxia. Prompt recognition condition is critical because early immunotherapy may confer a better prognosis.
Members of vulnerable populations are underrepresented in Parkinson's disease (PD) research. A complex web research barriers perpetuates this gap. Community-based methods one approach to addressing issue. The present PD study was designed examine the effectiveness community-based interventions overcome and increase participation among groups (URGs).