A5018402675- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Cerebral Palsy and Movement Disorders
- Balance, Gait, and Falls Prevention
- Advanced Neuroimaging Techniques and Applications
- Botulinum Toxin and Related Neurological Disorders
- Neurological diseases and metabolism
- Parkinson's Disease and Spinal Disorders
- Neurological and metabolic disorders
- Dysphagia Assessment and Management
- Stroke Rehabilitation and Recovery
- Attention Deficit Hyperactivity Disorder
- Cerebral Venous Sinus Thrombosis
- Autoimmune Neurological Disorders and Treatments
- Ophthalmology and Eye Disorders
- Transcranial Magnetic Stimulation Studies
- Alzheimer's disease research and treatments
- EEG and Brain-Computer Interfaces
- Amyotrophic Lateral Sclerosis Research
- Nuclear Receptors and Signaling
- Optical Imaging and Spectroscopy Techniques
- Advanced MRI Techniques and Applications
- Glycogen Storage Diseases and Myoclonus
- Assistive Technology in Communication and Mobility
- Ginkgo biloba and Cashew Applications
Oregon Health & Science University
2016-2025
Portland VA Medical Center
2023
VA Portland Health Care System
2015-2023
John Wiley & Sons (United States)
2023
Veterans Health Administration
2023
Medical University of South Carolina
2017-2022
Progressive supranuclear palsy (PSP) is a neurodegenerative disease without approved therapies, and therapeutics are often tried off-label in the hope of slowing progression. Results from these experiences seldom shared, which limits evidence-based knowledge to guide future treatment decisions.
Axial postural abnormalities are common and disabling motor complications of Parkinson's disease (PD) parkinsonism. They consist abnormal trunk or neck postures in the upright position, often interfering with daily life activities.1-5 A high number patients PD may develop one more axial abnormalities, which begin as minor forms, almost universal persons parkinsonism (eg, flexed posture lower limbs), progress to severe forms such camptocormia, antecollis, Pisa syndrome over 20% patients,1...
Abstract Background To date, no medication has slowed the progression of Parkinson’s disease (PD). Preclinical, epidemiological, and experimental data on humans all support many benefits endurance exercise among persons with PD. The key question is whether there a definitive additional benefit exercising at high intensity, in terms slowing progression, beyond well-documented training treadmill for fitness, gait, functional mobility. This study will determine efficacy high-intensity as...
There is emerging research detailing the relationship between balance/gait/falls and cognition. Imaging studies also suggest a link structural functional changes in frontal lobe (a region commonly associated with cognitive function) mobility. People Parkinson's disease have important function that may impact rehabilitation efficacy. Our underlying hypothesis connections basal ganglia brainstem posture/locomotor centers are responsible for postural deficits people play role The purpose of...
Falls in people with parkinsonism are likely related to both motor and cognitive impairments. In addition idiopathic Parkinson's disease (PD), some older adults have lower body (a frontal gait disorder), characterized by impaired extremity balance as well cognition, but without tremor or rigidity. Neuroimaging during virtual suggests that interhemispheric, prefrontal cortex communication may be involved locomotion, contributions of neuroanatomy connecting these regions objective measures...
Abstract Background The reliability of the Progressive Supranuclear Palsy Rating Scale (PSPRS) using teleneurology has not been assessed. Objectives To test whether removing items inadequately assessed by video would impact measurement PSP severity and progression. Methods We performed secondary analyses two data sets: phase 2/3 trial Davunetide in a large single‐center cohort. examined modifications PSPRS: (1) neck rigidity, limb postural stability (25 items; mPSPRS‐25) (2) also three...
Introduction Progressive supranuclear palsy (PSP) is characterized by early postural instability and backward falls. The mechanisms underlying in PSP are not understood. aim of this study was to test the hypothesis that a result dysfunction perception verticality. Methods We gathered posturography data on 12 subjects with compare idiopathic Parkinson's Disease (PD) healthy subjects. Objective tests impairment included: dynamic sensory gravity surface oscillations, responses perturbations,...
Freezing of gait (FoG) is a debilitating feature Parkinson's disease and other parkinsonian disorders. This case demonstrates variant freezing in non-parkinsonian patient with lesion the anterior corpus callosum. The improved increased upper extremity sensory input, suggesting that compensatory circuits for use somatosensory inputs from arms to postural locomotor centers were intact.
Introduction: Amantadine anecdotally improves gait in progressive supranuclear palsy (PSP) but definitive data is lacking. We investigated associations between amantadine usage, gait, cognition, and activities of daily living 310 subjects with PSP using from the davunetide trial. Method: compared baseline demographics, Rating Scale (PSPRS), Repeat Battery for Assessment Neuropsychological Status (RBANS), Schwab England Activities Daily Living (SEADL) scores taking vs. not chi-square tests...
Gerstmann-Straussler-Scheinker disease (GSS), an autosomal dominant prion disorder, usually presents as a slowly progressive cerebellar ataxia followed by later cognitive decline. We present member of the GSS Indiana Kindred with supranuclear palsy, less common feature in GSS.A 42-year-old man presented 12 months gait and balance difficulty. Exam was notable for eye movement abnormalities. Genetic testing revealed F198S variant protein (PRNP) gene, pathological associated his family,...
Many studies have examined aspects of balance in progressive supranuclear palsy (PSP), but guidance on the feasibility standardized objective assessments and scales PSP is lacking. Balance tests commonly used Parkinson's disease often cannot be easily administered or translated to PSP. Here we briefly review methodology prior PSP; then focus by presenting our experience with assessment PSP-Richardson syndrome PSP-parkinsonism during a crossover rTMS intervention trial. We highlight lessons...
We report a case of progressive supranuclear palsy-like phenotype with rapidly dementia and prominent language executive dysfunction. Pathological examination revealed no midbrain or white matter tauopathy, but rather chronic meningoencephalitis other mixed pathology. The cerebrospinal fluid (CSF) in this showed novel antibody against central nervous system renal tissue.
To evaluate the longitudinal performance of Montreal Cognitive Assessment (MoCA) as a measure cognitive outcomes in progressive supranuclear palsy (PSP).
Background The Montreal Cognitive assessment (MoCA) is a well-validated global cognitive screening instrument. Its validity in progressive supranuclear palsy (PSP) has not been assessed. Objectives To evaluate the MoCA as an outcome measure PSP clinical trials. Methods data from 162 participants placebo arm of Biogen PASSPORT study (NCT03068468) were analyzed using linear mixed-effects modeling (LMM) and repeated measures correlation. Results There was significant decline score over time...