Mehri Salari
A5078016071- Multiple Sclerosis Research Studies
- Parkinson's Disease Mechanisms and Treatments
- Peripheral Neuropathies and Disorders
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Neurological disorders and treatments
- Autoimmune Neurological Disorders and Treatments
- Glycogen Storage Diseases and Myoclonus
- Neurological diseases and metabolism
- Neurological and metabolic disorders
- RNA regulation and disease
- Infectious Encephalopathies and Encephalitis
- Genetic Neurodegenerative Diseases
- Botulinum Toxin and Related Neurological Disorders
- Immunotherapy and Immune Responses
- Systemic Lupus Erythematosus Research
- Epilepsy research and treatment
- Polyomavirus and related diseases
- Trace Elements in Health
- Neurogenetic and Muscular Disorders Research
- CRISPR and Genetic Engineering
- Pharmacological Effects and Toxicity Studies
- Retinal and Optic Conditions
- Autism Spectrum Disorder Research
- Ocular Diseases and Behçet’s Syndrome
Shahid Beheshti University of Medical Sciences
2018-2025
Shahid Beheshti University
2018-2024
Hemophilia Center of Iran
2024
University of Technology
2023
Isfahan University of Medical Sciences
2012-2023
Alzahra University
2018-2023
John Wiley & Sons (United States)
2023
Yasuj University of Medical Sciences
2022
Sahlgrenska University Hospital
2018
The University of Western Australia
2018
COVID-19 is speculated to increase the likelihood of relapsing-remitting multiple sclerosis (RRMS) exacerbation.To investigate association between contraction and incidence acute MS attacks in RRMS patients six months post-infection.This retrospective cohort study compares risk relapse with (n=56) without (n=69). Incidence was recorded for six-month following COVID-19. exacerbation compared (the independent control group) same prior pandemic.A lower rate observed that contracted than who did...
The Global Parkinson's Genetics Program (GP2) will genotype over 150,000 participants from around the world, and integrate genetic clinical data for use in large-scale analyses to dramatically expand our understanding of architecture PD. This report details workflow cohort integration into complex arm GP2, together with outline monogenic hub a companion paper, provides generalizable blueprint establishing large scale collaborative research consortia.
Abstract Genetic testing for persons with Parkinson's disease is becoming increasingly common. Significant gains have been made regarding genetic methods, and more readily available in clinical, research, direct‐to‐consumer settings. Although the potential utility of clinical expanding, there are currently no proven gene‐targeted therapies, but trials underway. Furthermore, practices vary widely, as do knowledge attitudes relevant stakeholders. The specter mandates financial, ethical,...
With the progress of COVID-19 vaccination programs worldwide, some new adverse events associated with available vaccines may unfold, especially in subpopulations, representatives whom were not included phase I, II, and III clinical trials these vaccines, such as patients autoimmune diseases, including multiple sclerosis (MS). A 34-year-old woman presented severe right hemiplegia ataxia. She was diagnosed relapsing-remitting MS (RRMS) 13 years ago treated rituximab (an anti-CD20 monoclonal...
Axial postural abnormalities are common and disabling motor complications of Parkinson's disease (PD) parkinsonism. They consist abnormal trunk or neck postures in the upright position, often interfering with daily life activities.1-5 A high number patients PD may develop one more axial abnormalities, which begin as minor forms, almost universal persons parkinsonism (eg, flexed posture lower limbs), progress to severe forms such camptocormia, antecollis, Pisa syndrome over 20% patients,1...
Abstract Using deep learning has demonstrated significant potential in making informed decisions based on clinical evidence. In this study, we deal with optimizing medication and quantitatively present the role of predicting dosage for patients Parkinson's disease (PD). The proposed method is recurrent neural networks (RNNs) tries to predict five critical types PD, including levodopa, dopamine agonists, monoamine oxidase-B inhibitors, catechol-O-methyltransferase amantadine. Recurrent have...
Headaches are more prevalent in patients with multiple sclerosis compared the general population. However, headaches still considered a rare symptom of sclerosis, especially when they appear as an initial symptom. The occurrence headache radiologically isolated syndrome (RIS) is uncommon, and it can significantly increase likelihood developing sclerosis. We report case 36-year-old Iranian woman experiencing severe unilateral without other symptoms. Despite normal physical laboratory exams,...
Abstract LRRK2 -PD represents the most common form of autosomal dominant Parkinson’s disease. We identified p.L1795F variant in three families and six additional unrelated cases using genetic data from over 50,000 individuals. Carriers with available genotyping shared a haplotype. The clinical presentation resembles other forms. Combined published functional evidence showing strongly enhanced kinase activity, we provide that is pathogenic.
Our goal was to identify the gene(s) associated with an early-onset form of Parkinson disease (PD) and molecular defects this mutation.We combined whole-exome sequencing functional genomics genes PD. We used fluorescence microscopy, cell, mitochondrial biology measurements resulting from identified mutation.Here, we report association a homozygous variant in CHCHD2, encoding coiled-coil-helix-coiled-coil-helix domain containing protein 2, unknown function, PD 26-year-old Caucasian woman. The...
There have been no specific guidelines regarding which genes should be tested in the clinical setting for Parkinson's disease (PD) or parkinsonism. We evaluated types of genetic testing offered PD as first step our gene curation.
Abstract Background There is growing clinical and research utilization of genetic testing in Parkinson's disease (PD), including direct‐to‐consumer testing. Objectives The aim to determine the international landscape PD inform future worldwide recommendations. Methods A web‐based survey assessing current practices, concerns, barriers counseling was administered International Parkinson Movement Disorders Society membership. Results Common hurdles across sites included cost access testing,...
Abstract MicroRNAs (miRNAs) have been reported to contribute the pathophysiology of Parkinson’s disease (PD), an age related-neurodegenerative disorder. The aim present study was compare expression profiles a new set candidate miRNAs related aging and cellular senescence in peripheral blood mononuclear cells (PBMCs) obtained from PD patients with healthy controls then early advanced stages their clarify whether correlated severity. We also proposed consensus-based strategy interpret data...
Abstract PGC‐1α/FNDC5/BDNF has found to be a critical pathway in neurodegeneration. MicroRNAs (miR(NA)s) are non‐coding regulatory RNAs whose dysregulation been observed multiple neurological disorders, and miRNA‐mediated gene deregulation plays decisive role PD. Here, candidate miRNA was chosen based on the literature survey silico studies. Chronic acute models of PD were created using MPP+‐treated SH‐SY5Y cells. Twenty patients 20 healthy volunteers recruited. RT‐qPCR performed assess...