Xiaopu Zhou
A5021156794- Alzheimer's disease research and treatments
- Bioinformatics and Genomic Networks
- Genetic Associations and Epidemiology
- IL-33, ST2, and ILC Pathways
- Machine Learning in Bioinformatics
- Eosinophilic Esophagitis
- Metabolomics and Mass Spectrometry Studies
- Mitochondrial Function and Pathology
- Parkinson's Disease Mechanisms and Treatments
- CRISPR and Genetic Engineering
- Neuroscience and Neuropharmacology Research
- Dementia and Cognitive Impairment Research
- Autism Spectrum Disorder Research
- Genomics and Rare Diseases
- Genomics and Phylogenetic Studies
- Genetics and Neurodevelopmental Disorders
- Neurological diseases and metabolism
- Health, Environment, Cognitive Aging
- S100 Proteins and Annexins
- MicroRNA in disease regulation
- RNA and protein synthesis mechanisms
- Supercapacitor Materials and Fabrication
- Pharmaceutical Practices and Patient Outcomes
- RNA Research and Splicing
- Retinal Development and Disorders
University of Hong Kong
2015-2024
Hong Kong University of Science and Technology
2015-2024
HKUST Shenzhen Research Institute
2020-2024
SickKids Foundation
2024
Hospital for Sick Children
2024
Hong Kong Science and Technology Parks Corporation
2020-2023
Life University
2015
Tianjin Normal University
2013-2014
Significance Dysfunction of the innate immune system is involved in pathogenesis Alzheimer’s disease (AD); however, pathophysiological mechanisms underlying these dysfunctions are unclear. Here we report that stimulation IL-33/ST2 signaling rescues memory deficits and reduces accumulation β-amyloid APP/PS1 mice exhibit select pathologies associated with AD. Although impaired early progression AD, IL-33 injection contextual mice. skews microglia toward an alternative activation state enhanced...
Blood proteins are emerging as candidate biomarkers for Alzheimer's disease (AD). We systematically profiled the plasma proteome to identify novel AD blood and develop a high-performance, blood-based test AD.
Abstract Alzheimer’s disease (AD) is a leading cause of mortality in the elderly. While coding change APOE -ε4 key risk factor for late-onset AD and has been believed to be only locus, it does not fully explain effect conferred by locus. Here, we report identification causal variants PVRL2 APOC1 regions proximity define common haplotypes independent change. These are associated with changes AD-related endophenotypes including cognitive performance, altered expression its nearby genes human...
Alzheimer’s disease (AD) is a leading cause of mortality among the elderly. We performed whole-genome sequencing study AD in Chinese population. In addition to variants identified or around APOE locus (sentinel variant rs73052335, P = 1.44 × 10 −14 ), two common variants, GCH1 (rs72713460, 4.36 −5 ) and KCNJ15 (rs928771, 3.60 −6 were further verified for their possible risk effects three small non-Asian cohorts. Genotype–phenotype analysis showed that rs928771 affects onset age AD, with...
Abstract Background The polygenic nature of Alzheimer’s disease (AD) suggests that multiple variants jointly contribute to susceptibility. As an individual’s genetic are constant throughout life, evaluating the combined effects disease-associated risks enables reliable AD risk prediction. Because complexity genomic data, current statistical analyses cannot comprehensively capture AD, resulting in unsatisfactory However, deep learning methods, which nonlinearity within high-dimensional may...
The Global Parkinson's Genetics Program (GP2) will genotype over 150,000 participants from around the world, and integrate genetic clinical data for use in large-scale analyses to dramatically expand our understanding of architecture PD. This report details workflow cohort integration into complex arm GP2, together with outline monogenic hub a companion paper, provides generalizable blueprint establishing large scale collaborative research consortia.
Blood protein biomarkers demonstrate potential for Alzheimer's disease (AD) diagnosis. Limited studies examine the molecular changes in AD blood cells.
Changes in the levels of circulating proteins are associated with Alzheimer's disease (AD), whereas their pathogenic roles AD unclear. Here, we identified soluble ST2 (sST2), a decoy receptor interleukin-33-ST2 signaling, as new disease-causing factor AD. Increased sST2 level is more severe pathological changes female individuals Genome-wide association analysis and CRISPR-Cas9 genome editing rs1921622 , genetic variant an enhancer element IL1RL1, which downregulates gene protein sST2....
Abstract LRRK2 -PD represents the most common form of autosomal dominant Parkinson’s disease. We identified p.L1795F variant in three families and six additional unrelated cases using genetic data from over 50,000 individuals. Carriers with available genotyping shared a haplotype. The clinical presentation resembles other forms. Combined published functional evidence showing strongly enhanced kinase activity, we provide that is pathogenic.
The proper growth and arborization of dendrites in response to sensory experience are essential for neural connectivity information processing the brain. Although neuronal activity is important sculpting dendrite morphology, underlying molecular mechanisms not well understood. Here, we report that cyclin-dependent kinase 5 (Cdk5)-mediated transcriptional regulation a key mechanism controls activity-dependent development cultured rat neurons. During membrane depolarization, Cdk5 accumulates...
Biochemical, pathogenic, and human genetic data confirm that GSAP (γ-secretase activating protein), a selective γ-secretase modulatory protein, plays important roles in Alzheimer's disease (AD) Down's syndrome. However, the molecular mechanism(s) underlying GSAP-dependent pathogenesis remains largely elusive. Here, through unbiased proteomics single-nuclei RNAseq, we identified regulates multiple biological pathways, including protein phosphorylation, trafficking, lipid metabolism,...
Genetic studies reveal that single-nucleotide polymorphisms (SNPs) of SPI1 are associated with Alzheimer's disease (AD), while their effects in the Chinese population remain unclear.We aimed to examine AD-association SNPs and investigate underlying mechanisms these modulating AD risk.We conducted a genetic analysis three (i.e., rs1057233, rs3740688, rs78245530) cohort (n = 333 patients AD, n 721 normal controls). We also probed public European-descent cohorts gene expression datasets...
Abstract Recent multi‐omics analyses paved the way for a comprehensive understanding of pathological processes. However, only few studies have explored Alzheimer’s disease (AD) despite possibility biological subtypes within these patients. For this study, unsupervised classification four datasets (genetics, miRNA transcriptomics, proteomics, and blood‐based biomarkers) using Multi‐Omics Factor Analysis+ (MOFA+), along with systems‐biological approaches following various downstream are...
Introduction Dozens of Alzheimer's disease (AD)-associated loci have been identified in European-descent populations, but their effects not thoroughly investigated the Hong Kong Chinese population. Methods TaqMan array genotyping was performed for known AD-associated variants a cohort. Regression analysis conducted to study associations with traits and biomarkers. Lasso regression applied establish polygenic risk score (PRS) model AD prediction. Results SORL1 is associated Meta-analysis...
Abstract INTRODUCTION The SORL1 locus exhibits protective effects against Alzheimer's disease (AD) across ancestries, yet systematic studies in diverse populations are sparse. METHODS Logistic regression identified AD‐associated haplotypes East Asian ( N = 5249) and European 8588) populations. Association analysis between traits or plasma biomarkers was conducted. of non‐synonymous mutations were assessed cell‐based systems. RESULTS Protective variants/haplotypes the Haplotype Hap_A showed a...
Porous silicon carbonitride (SiCN) ceramics were pyrolyzed from poly(silylcarbondiimide) derivatives, followed by etching with different concentrations of HF aqueous solution (5, 10, 15 and 20 wt%). The morphologies, structures electrochemical performances the HF-etched SiCN materials investigated. results indicated that surface composites became rough porous. SiCN-10-HF, one four samples, showed excellent properties as an anode for lithium ion batteries. Charge–discharge measurements...
During development, scaffold proteins serve as important platforms for orchestrating signaling complexes to transduce extracellular stimuli into intracellular responses that regulate dendritic spine morphology and function. Axin ("axis inhibitor") is a key protein in canonical Wnt interacts with specific synaptic proteins. However, the cellular functions of these protein–protein interactions regulation are unclear. Here, we report enriched fractions, colocalizes postsynaptic marker PSD-95...
Alzheimer's disease is an irreversible neurodegenerative disorder for which we have limited knowledge of the mechanisms underlying its pathogenesis, especially molecular events that trigger deterioration neuronal functions in early stage. Protein phosphorylation and dephosphorylation are highly dynamic reversible post-translational modifications control protein signaling hence functions, aberrations implicated various diseases including disease. We conducted a quantitative phosphoproteomic...
Self-supervised pre-training methods have brought remarkable breakthroughs in the understanding of text, image, and speech. Recent developments genomics has also adopted these for genome understanding. However, they focus only on haploid sequences, which hinders their applicability towards genetic variations, known as single nucleotide polymorphisms (SNPs), is crucial genome-wide association study. In this paper, we introduce SNP2Vec, a scalable self-supervised approach SNP. We apply SNP2Vec...
Abstract Recent advances in genetic sequencing have enabled comprehensive analyses of human diseases, resulting the identification numerous risk factors for heritable disorders including Alzheimer’s disease (AD). Such enable AD prediction well before onset, which is critical early interventions. However, current analytical approaches limited ability to accurately estimate effects variants owing epistatic effects, been overlooked most previous studies, unsatisfactory prediction. Herein, we...