A5023136222- Autophagy in Disease and Therapy
- Metabolism, Diabetes, and Cancer
- Cell Adhesion Molecules Research
- Ubiquitin and proteasome pathways
- Growth Hormone and Insulin-like Growth Factors
- Cancer, Hypoxia, and Metabolism
- PI3K/AKT/mTOR signaling in cancer
- Fibroblast Growth Factor Research
- Epigenetics and DNA Methylation
- Bioinformatics and Genomic Networks
- Adenosine and Purinergic Signaling
- Cancer Cells and Metastasis
- Protein Tyrosine Phosphatases
- Cellular transport and secretion
- Cellular Mechanics and Interactions
- Alzheimer's disease research and treatments
- Cytokine Signaling Pathways and Interactions
- Genetic Associations and Epidemiology
- Cancer-related gene regulation
- HER2/EGFR in Cancer Research
- Hedgehog Signaling Pathway Studies
- Molecular Biology Techniques and Applications
- Endoplasmic Reticulum Stress and Disease
- Mitochondrial Function and Pathology
- Prostate Cancer Treatment and Research
University of Massachusetts Chan Medical School
2015-2024
San Francisco VA Medical Center
2024
University of California, San Francisco
2024
University of Pennsylvania
1976-2022
Institute of Molecular and Cell Biology
2018
Elucid Bioimaging
2017
European Commission
2017
Philadelphia University
2017
Massachusetts Academy of Math and Science
2011-2015
Institute of Molecular Medicine
2014
In comparison to the internalization pathways of endocytosis, recycling are less understood. Even defined is process regulated recycling, as few examples exist and their underlying mechanisms remain be clarified. this study, we examine endocytic integrin β1, a that has been suggested play an important role during cell motility by mediating redistribution integrins migrating front. External stimulation regulates itinerary mainly at internal compartment likely subset endosomes. This...
We define a novel mechanism by which integrins regulate growth factor expression and the survival of carcinoma cells. Specifically, we demonstrate that α6β4 integrin enhances vascular endothelial (VEGF) translation in breast The involves ability this to stimulate phosphorylation inactivation 4E-binding protein (4E-BP1), translational repressor inhibits function eukaryotic initiation 4E (eIF-4E). regulation 4E-BP1 derives from activate PI-3K–Akt pathway and, consequently, rapamycin-sensitive...
Objective: The objective of this study was to determine whether certain biomarkers toxicity and/or a past diagnosis liver or thyroid disease were associated with serum perfluorooctanoate concentrations (PFOA) in community longstanding environmental exposure PFOA. Methods: Serum (PFOA), hematologic and biochemical biomarkers, questionnaire administered 371 residents selected by stratified random sampling lottery among volunteers. Median PFOA 354 ng/mL (interquartile range, 181–571 ng/mL)....
The Insulin Receptor Substrate (IRS) proteins are cytoplasmic adaptor that function as essential signaling intermediates downstream of activated cell surface receptors, many which have been implicated in cancer. IRS do not contain any intrinsic kinase activity, but rather serve scaffolds to organize complexes and initiate intracellular pathways. As common multiple receptors can influence tumor progression, the positioned play a pivotal role regulating response cells different...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDescription of two procedures which avoid the use extreme pH conditions for resolution components isolated from chromatins prepared pig cerebellar and pituitary nucleiLeslie M. J. Shaw Ru-Chi-Chow HuangCite this: Biochemistry 1970, 9, 23, 4530–4542Publication Date (Print):November 1, 1970Publication History Published online1 May 2002Published inissue 1 November...
Although the α6β1 integrin has been implicated in function of breast and other cancer stem cells (CSCs), little is known about its regulation relationship to mechanisms involved genesis CSCs. We report that a CD44high/CD24low population, enriched for CSCs, comprised distinct epithelial mesenchymal populations differ expression two α6 cytoplasmic domain splice variants: α6A α6B. α6Bβ1 defines population necessary CSC function, cannot be executed by integrins. The generation tightly controlled...
Adenosine triphosphate (ATP) synthase β, the catalytic subunit of mitochondrial complex V, synthesizes ATP. We show that ATP β is deacetylated by a human nicotinamide adenine dinucleotide (NAD+)–dependent protein deacetylase, sirtuin 3, and its Drosophila melanogaster homologue, dSirt2. dsirt2 mutant flies displayed increased acetylation specific Lys residues in decreased V activity. Overexpression dSirt2 Substitution 259 480 with Arg mimicking deacetylation, activity, whereas substitution...
Dysregulation of sphingomyelin and ceramide metabolism have been implicated in Alzheimer's disease. Genome-wide transcriptome-wide association studies identified various genes genetic variants lipid that are associated with However, the molecular mechanisms disruption remain to be determined. We focus on sphingolipid pathway carry out multi-omics analyses identify central peripheral metabolic changes patients, correlating them imaging features. Our approach is based (a) 2114 human...
AbstractExpression of the α6β4 integrin increases invasive potential carcinoma cells by a mechanism that involves activation phosphoinositide 3-OH kinase (PI3K). In present study, we investigated signaling pathway which activates PI3K. Neither α6 nor β4 cytoplasmic domain contains consensus binding motif for PI3K, pYMXM, indicating additional proteins are likely to be involved in this lipid integrin. We identified insulin receptor substrate 1 (IRS-1) and IRS-2 as intermediates PI3K IRS-1...
Appetite stimulation by cannabinoids is highly variable. Four within-subject design studies explored the effects of age, gender, satiety status, route drug administration, and dose on intake. One study involved a single oral administration active (15 mg males, 10 females) or placebo to an age gender stratified sample 57 healthy, adult light marijuana users. Eleven subjects received doses oral, sublingual, inhaled routes in second study. In third study, ingested fasted fed states. A 2.5 was...
Runx1 is a transcription factor essential for definitive hematopoiesis, and genetic abnormalities in cause leukemia. functionally promiscuous acts as either an oncogene or tumor suppressor gene certain epithelial cancers. Recent evidence suggests that important breast cancer, however, its role remains ambiguous. Here, we addressed whether has specific pathological during cancer progression show oncogenic function. We observed elevated expression subset of human Furthermore, throughout the...
Polygenic effects have been proposed to account for some disease phenotypes; these are calculated as a polygenic risk score (PRS). This is correlated with Alzheimer's (AD)-related phenotypes, such biomarker abnormalities and brain atrophy, associated conversion from mild cognitive impairment (MCI) AD. However, the AD PRS has examined mainly in Europeans, owing differences genetic structure lifestyle, it unclear whether same relationships between AD-related phenotypes exist non-European...
The insulin receptor substrate (IRS) proteins are adaptor molecules that integrate signals generated by receptors implicated in human breast cancer.We investigated the specific contribution of IRS-2 to mammary tumor progression using transgenic mice express polyoma virus middle T antigen (PyV-MT) gland and IRS-2-null (IRS-2 ؊/؊ ) mice.PyV-MT-induced initiation growth were similar wild-type (WT) mice.However, latency incidence metastasis significantly decreased absence expression.The is...