A5052182874- Metabolomics and Mass Spectrometry Studies
- Diet and metabolism studies
- Bioinformatics and Genomic Networks
- Dermatology and Skin Diseases
- Alzheimer's disease research and treatments
- Mitochondrial Function and Pathology
- Tryptophan and brain disorders
- COVID-19 Clinical Research Studies
- Modular Robots and Swarm Intelligence
- Gene expression and cancer classification
- Psoriasis: Treatment and Pathogenesis
- Microbial Metabolic Engineering and Bioproduction
- Adipose Tissue and Metabolism
- Micro and Nano Robotics
- Sepsis Diagnosis and Treatment
- Asthma and respiratory diseases
- Gut microbiota and health
- Metabolism and Genetic Disorders
- Neuroblastoma Research and Treatments
- Long-Term Effects of COVID-19
- Respiratory Support and Mechanisms
- Allergic Rhinitis and Sensitization
- Cell Image Analysis Techniques
- Nutrition, Genetics, and Disease
- RNA modifications and cancer
Cornell University
2020-2025
Weill Cornell Medicine
2020-2025
Columbia University
2019-2024
Lander Institute
2021-2023
Helmholtz Zentrum München
2016-2022
Institute for Biomedicine
2022
Technical University of Munich
2016-2020
University of Chicago
2020
University of Southern Denmark
2014-2017
German Center for Lung Research
2017
Importance Metabolomics reflect the net effect of genetic and environmental influences thus provide a comprehensive approach to evaluating pathogenesis complex diseases, such as depression. Objective To identify metabolic signatures major depressive disorder (MDD), elucidate direction associations using mendelian randomization, evaluate interplay human gut microbiome metabolome in development MDD. Design, Setting Participants This cohort study used data from participants UK Biobank (n = 500...
Abstract As spaceflight becomes more common with commercial crews, blood-based measures of crew health can guide both astronaut biomedicine and countermeasures. By profiling plasma proteins, metabolites, extracellular vesicles/particles (EVPs) from the SpaceX Inspiration4 crew, we generated “spaceflight secretome profiles,” which showed significant differences in coagulation, oxidative stress, brain-enriched proteins. While >93% differentially abundant proteins (DAPs) vesicles metabolites...
Alzheimer's disease (AD) is a major neurodegenerative disorder with significant environmental factors, including diet and lifestyle, influencing its onset progression. Although previous studies have suggested that certain diets may reduce the incidence of AD, underlying mechanisms remain unclear. In this post-hoc analysis randomized crossover study 20 elderly adults, we investigated effects modified Mediterranean ketogenic (MMKD) on plasma lipidome in context AD biomarkers, analyzing 784...
Dysregulation of sphingomyelin and ceramide metabolism have been implicated in Alzheimer's disease. Genome-wide transcriptome-wide association studies identified various genes genetic variants lipid that are associated with However, the molecular mechanisms disruption remain to be determined. We focus on sphingolipid pathway carry out multi-omics analyses identify central peripheral metabolic changes patients, correlating them imaging features. Our approach is based (a) 2114 human...
Alzheimer's disease (AD) is accompanied by metabolic alterations both in the periphery and central nervous system. However, so far, a global view of AD-associated changes brain has been missing.
Increasing evidence suggests that metabolic impairments contribute to early Alzheimer's disease (AD) mechanisms and subsequent dementia. Signals in pathways conserved across species can facilitate translation.
Abstract Background Acute respiratory distress syndrome (ARDS), a life-threatening condition during critical illness, is common complication of COVID-19. It can originate from various disease etiologies, including severe infections, major injury, or inhalation irritants. ARDS poses substantial clinical challenges due to lack etiology-specific therapies, multisystem involvement, and heterogeneous, poor patient outcomes. A molecular comparison groups holds the potential reveal distinct...
Alzheimer's disease (AD) is influenced by a variety of modifiable risk factors, including person's dietary habits. While the ketogenic diet (KD) holds promise in reducing metabolic risks and potentially affecting AD progression, only few studies have explored KD's impact, especially on blood cerebrospinal fluid (CSF). Our study involved participants at for AD, either cognitively normal or with mild cognitive impairment. The consumed both modified Mediterranean Ketogenic Diet (MMKD) American...
Over the last decade network enrichment analysis has become popular in computational systems biology to elucidate aberrant modules. Traditionally, these approaches focus on combining gene expression data with protein-protein interaction (PPI) networks. Nowadays, so-called omics technologies allow for inclusion of many more sets, e.g. protein phosphorylation or epigenetic modifications. This creates a need methods that can combine various sources obtain systems-level view biological We...
Summary Selecting the most promising treatment strategy for breast cancer crucially depends on determining correct subtype. In recent years, gene expression profiling has been investigated as an alternative to histochemical methods. Since databases like TCGA provide easy and unrestricted access data hundreds of patients, challenge is extract a minimal optimal set genes with good prognostic properties from large bulk making moderate contribution classification. Several studies have...
Abstract Nonsense‐mediated RNA decay ( NMD ) is an ‐based quality control mechanism that eliminates transcripts bearing premature translation termination codons PTC ). Approximately, one‐third of all inherited disorders and some forms cancer are caused by nonsense or frame shift mutations introduce s, can modulate the clinical phenotype these diseases. 5‐azacytidine analogue naturally occurring pyrimidine nucleoside cytidine, which approved for treatment myelodysplastic syndrome myeloid...
The tumor microenvironment is composed of many immune cell subpopulations and an important factor in the malignant progression neoplasms, particularly breast cancer (BC). However, cytokine networks that coordinate various regulatory events within BC interstitium remain largely uncharacterized. Moreover, data obtained regarding origin secretions, levels secretion associated with development, possible clinical relevance cytokines controversial. Therefore, we profiled 27 78 interstitial fluid...
Gene expression profiles have been extensively discussed as an aid to guide the therapy by predicting disease outcome for patients suffering from complex diseases, such cancer. However, prediction models built upon single-gene (SG) features show poor stability and performance on independent datasets. Attempts mitigate these drawbacks led development of network-based approaches that integrate pathway information produce meta-gene (MG) features. Also, MG only dealt with two-class problem good...
BackgroundA standardized human model to study early pathogenic events in patients with psoriasis is missing. Activation of Toll-like receptor 7/8 by means topical application imiquimod the most commonly used mouse psoriasis.ObjectiveWe sought investigate potential a patch test resemble psoriasis.MethodsImiquimod (Aldara 5% cream; 3M Pharmaceuticals, St Paul, Minn) was applied twice week backs volunteers (n = 18), and development skin lesions monitored over period 4 weeks. Consecutive biopsy...
Abstract De novo pathway enrichment is a powerful approach to discover previously uncharacterized molecular mechanisms in addition already known pathways. To achieve this, condition-specific functional modules are extracted from large interaction networks. Here, we give an overview of the state art and present first framework for assessing performance existing methods. We identified 19 tools selected seven representative candidates comparative analysis with more than 12,000 runs, spanning...
Abstract The number of pregnancies complicated by gestational diabetes (GDM) is increasing worldwide. To identify novel characteristics GDM, we studied miRNA profiles maternal and fetal whole blood cells (WBCs) from GDM normal glucose tolerant (NGT) pregnant women matched for body mass index age. After adjustment weight gain pregnancy week, identified 29 mature micro-RNAs (miRNAs) up-regulated in one which, i.e., miRNA-340, was validated qPCR. mRNA protein expression PAIP1, a miRNA-340...
Background Acute respiratory distress syndrome (ARDS), a life-threatening condition characterized by hypoxemia and poor lung compliance, is associated with high mortality. ARDS induced COVID-19 has similar clinical presentations pathological manifestations as non-COVID-19 ARDS. However, more protracted inflammatory failure compared to traditional Therefore, comprehensive molecular comparison of different etiologies groups may pave the way for specific interventions. Methods findings In this...
Abstract This article presents maplet, an open-source R package for the creation of highly customizable, fully reproducible statistical pipelines metabolomics data analysis. It builds on SummarizedExperiment structure to create a centralized pipeline framework storing data, analysis steps, results and visualizations. maplet’s key design feature is its modularity, which offers several advantages, such as ensuring code quality through maintenance individual functions promoting collaborative...
Abstract BACKGROUND Metabolic dysregulation is a hallmark of neurodegenerative diseases, including Alzheimer's disease (AD) and progressive supranuclear palsy (PSP). Although metabolic common link between these two tauopathies, comprehensive brain comparison the diseases has not yet been performed. METHODS We analyzed 342 postmortem samples from Mayo Clinic Brain Bank examined 658 metabolites in cerebellar cortex temporal tauopathies. RESULTS Our findings indicate that both display oxidative...
The coronavirus disease-19 (COVID-19) pandemic has ravaged global healthcare with previously unseen levels of morbidity and mortality. In this study, we performed large-scale integrative multi-omics analyses serum obtained from COVID-19 patients the goal uncovering novel pathogenic complexities disease identifying molecular signatures that predict clinical outcomes. We assembled a network protein-metabolite interactions through targeted metabolomic proteomic profiling in 330 compared to 97...
Abstract Experimental models shows that bioenergetic homeostasis changes with increasing age based on apolipoprotein E ( APOE ) gene. However, such link dementia remains unclear in population. We used H 1 -NMR metabolome blood from 118,021 random-selected participants UK Biobank (n=118,021 individuals), and identified 56 metabolites associated the risk of dementia. In without developing during follow-up, 82% (46/56) are also reaction time, shares metabolite signatures total brain volume....
Neuroblastoma is the most common extra-cranial solid tumor of early childhood. Standard therapies are not effective in case poor prognosis and chemotherapy resistance. To improve drug therapy, it imperative to discover new targets that play a substantial role tumorigenesis neuroblastoma. The mitotic machinery an attractive target for therapeutic interventions inhibitors can be developed entry, spindle apparatus, activation checkpoint, exit. We present elaborate analysis pipeline determine...
Abstract Computational approaches for automatic analysis of image‐based high‐throughput and high‐content screens are gaining increased importance to cope with the large amounts data generated by automated microscopy systems. Typically, image is used extract phenotypic information once all images a screen have been acquired. However, also in earlier stages large‐scale experiments important, particular, support accelerate tedious time‐consuming optimization experimental conditions technical...