A5038367542- Metabolomics and Mass Spectrometry Studies
- Diet and metabolism studies
- Cancer, Lipids, and Metabolism
- Adipose Tissue and Metabolism
- Fatty Acid Research and Health
- Lipoproteins and Cardiovascular Health
- Liver Disease Diagnosis and Treatment
- Birth, Development, and Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cholesterol and Lipid Metabolism
- Advanced Proteomics Techniques and Applications
- Lipid metabolism and biosynthesis
- Genetic Associations and Epidemiology
- Barrier Structure and Function Studies
- Alzheimer's disease research and treatments
- Sphingolipid Metabolism and Signaling
- Neurological Disease Mechanisms and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Hormonal and reproductive studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Nutritional Studies and Diet
- Lipid metabolism and disorders
- Biochemical effects in animals
- Atrial Fibrillation Management and Outcomes
Baker Heart and Diabetes Institute
2018-2025
The University of Melbourne
2021-2025
La Trobe University
2023-2024
Curtin University
2012-2021
Innovation Research Center
2012-2021
Campo Arqueologico de Mertola
2019
Nutrition 21 (United States)
2019
Functional loss of blood–brain barrier (BBB) is suggested to be pivotal pathogenesis and pathology vascular-based neurodegenerative disorders such as Alzheimer’s disease. We recently reported in wild-type mice maintained on standard diets, progressive deterioration capillary function with aging concomitant heightened neuroinflammation. However, the used this study were relatively young (12 months age) potential mechanisms for integrity not investigated per se. The current therefore extended...
Myocardial infarction (MI) is a leading cause of mortality and morbidity worldwide new treatment strategies are highly sought-after. Paradoxically, reperfusion the ischemic myocardium, as achieved with early percutaneous intervention, results in substantial damage to heart (ischemia/reperfusion injury) caused by cell death due aggravated inflammatory oxidative stress responses. Chronic therapy vitamin E not effective reducing cardiovascular event rate, presumably through failing reduce...
Diabetic insulin resistance and pro-diabetic diet are reported to increase dementia risk through unknown mechanisms. Emerging evidence suggests that the integrity of blood-brain barrier (BBB) is central onset progression neurodegeneration cognitive impairment. Therefore, current study investigated effect diets on dysfunction in association BBB its putative In C57BL/6J mice chronically ingested with a enriched fat fructose (HFF), Morris water maze test indicated no significant decline after 4...
BACKGROUND. Plasma lipidomic measures may enable improved prediction of cardiovascular outcomes in secondary prevention. The aim this study is to determine the association plasma measurements with events and assess their potential predict such events.
Obesity and related metabolic diseases show clear sex-related differences. The growing burden of these calls for better understanding the age- consequences. High-throughput lipidomic analyses population-based cohorts offer an opportunity to identify disease-risk–associated biomarkers improve our lipid metabolism biology at a population level. Here, we comprehensively examined relationship between classes/subclasses molecular species with age, sex, body mass index (BMI). Furthermore,...
Abstract Changes to lipid metabolism are tightly associated with the onset and pathology of Alzheimer’s disease (AD). Lipids complex molecules comprising many isomeric isobaric species, necessitating detailed analysis enable interpretation biological significance. Our expanded targeted lipidomics platform (569 species across 32 classes) allows for separation characterisation. In this study we examined peripheral samples two cohorts (AIBL, n = 1112 ADNI, 800). We able identify concordant...
Obesity is a risk factor for type 2 diabetes and cardiovascular disease. However, substantial proportion of patients with these conditions have seemingly normal body mass index (BMI). Conversely, not all obese individuals present metabolic disorders giving rise to the concept "metabolically healthy obese". We use lipidomic-based models BMI calculate score (mBMI) as measure dysregulation associated obesity. Using difference between mBMI (mBMIΔ), we identify similar but differing in their...
Alzheimer's disease (AD) is a major neurodegenerative disorder with significant environmental factors, including diet and lifestyle, influencing its onset progression. Although previous studies have suggested that certain diets may reduce the incidence of AD, underlying mechanisms remain unclear. In this post-hoc analysis randomized crossover study 20 elderly adults, we investigated effects modified Mediterranean ketogenic (MMKD) on plasma lipidome in context AD biomarkers, analyzing 784...
Exercise-induced heart growth provides protection against cardiovascular disease, whereas disease-induced leads to failure. These distinct forms of are associated with different molecular profiles (e.g., mRNAs, non-coding RNAs, and proteins), targeting differentially regulated genes has therapeutic potential for The effects exercise on the cardiac circulating lipidomes in comparison disease unclear. Lipidomic profiling was performed hearts plasma mice subjected swim endurance training or a...
Adipose-tissue-resident macrophages (ATMs) maintain metabolic homeostasis but also contribute to obesity-induced adipose tissue inflammation and dysfunction. Central these contrasting effects of ATMs on is the interaction with fatty acids. Fatty acid levels are increased within in various pathological physiological conditions, appear initiate inflammatory responses only upon particular macrophage subsets obese tissue. The molecular basis underlying divergent outcomes likely due phenotypic...
Autism omics research has historically been reductionist and diagnosis centric, with little attention paid to common co-occurring conditions (for example, sleep feeding disorders) the complex interplay between molecular profiles neurodevelopment, genetics, environmental factors health. Here we explored plasma lipidome (783 lipid species) in 765 children (485 diagnosed autism spectrum disorder (ASD)) within Australian Biobank. We identified lipids associated ASD (n = 8), disturbances 20)...
Accurate risk stratification is vital for primary prevention of cardiovascular disease (CVD). However, traditional tools such as the Framingham Risk Score (FRS) may underperform within diverse intermediate-risk group, which includes individuals requiring distinct management strategies. This study aimed to develop a lipidomic-enhanced score (LRS), specifically targeting prediction and reclassification intermediate benchmarked against FRS. The LRS was developed via machine learning workflow...
Abstract Background Emerging evidence suggests that disturbances in the blood–brain barrier (BBB) may be pivotal to pathogenesis and pathology of vascular-based neurodegenerative disorders. Studies suggest heightened systemic central inflammations are associated with BBB dysfunction. This study investigated effect anti-inflammatory nutraceuticals garlic extract-aged (GEA), alpha lipoic acid (ALA), niacin, nicotinamide (NA) a murine dietary-induced model Methods C57BL/6 mice were fed diet...
Disturbances in blood-brain barrier (BBB) integrity contribute to the onset and progression of neurodegenerative diseases including Alzheimer's disease (AD) vascular dementia (VaD). Aging is positively associated with AD VaD risk, but this may reflect comorbidities or effects other chronic modulators function such as diet.To explore putative synergistic aging diet, study genetically unmanipulated mice were maintained on diets enriched saturated fatty acids (SFA) cholesterol compared provided...
Background Although acute coronary syndromes (ACS) are a major cause of morbidity and mortality, relationships with biologically active lipid species potentially associated plaque disruption/erosion in the context their lipoprotein carriers indeterminate. The aim was to characterize within particles which differentiate ACS from stable artery disease. Methods Results Venous blood obtained 130 individuals de novo presentation an (n=47) or disease (n=83) before catheterization. Lipidomic...
Adipose tissue is essential for metabolic homeostasis, balancing lipid storage and mobilization based on nutritional status. This coordinated by insulin, which triggers kinase signaling cascades to modulate numerous proteins, leading increased glucose uptake anabolic processes like lipogenesis. Given recent evidence that dispensable adipocyte respiration, we sought test whether necessary insulin-stimulated anabolism. Examining lipogenesis in cultured adipocytes, was insulin stimulate the...
CVD is the leading cause of death worldwide, and genetic investigations into human lipidome may provide insight risk. The aim this study was to estimate heritability circulating lipid species their correlation with traits. Targeted lipidomic profiling performed on 4,492 participants from Busselton Family Heart Study quantify major fatty acids 596 33 classes. We estimated narrow-sense heritabilities species/classes correlations eight traits: BMI, HDL-C, LDL-C, triglycerides, total...
Abstract Introduction The apolipoprotein E ( APOE ) genotype is the strongest genetic risk factor for late‐onset Alzheimer's disease. However, its effect on lipid metabolic pathways, and their mediating disease risk, poorly understood. Methods We performed lipidomic analysis three independent cohorts (the Australian Imaging, Biomarkers Lifestyle [AIBL] flagship study, n = 1087; Disease Neuroimaging Initiative [ADNI] 1 819; Busselton Health Study [BHS], 4384), we defined associations between...
Abstract Background Lipids play a vital role in health and disease, but changes to their circulating levels the link with obesity remain poorly characterized expecting mothers offspring early childhood. Methods LC-MS/MS-based quantitation of 480 lipid species was performed on 2491 plasma samples collected at 4 time points mother-offspring Asian cohort GUSTO (Growing Up Singapore Towards healthy Outcomes). These constituted from 26–28 weeks gestation ( n =752) 4–5 years postpartum =650),...
VITT has emerged as a rare but serious adverse event linked primarily to adenoviral vector COVID-19 vaccinations, such ChAdOx1-S (Oxford/AstraZeneca) vaccination. The syndrome is characterized by thrombosis with thrombocytopenia, elevated D-dimer, and pathologic platelet factor 4 antibodies within 42 days of Despite dysregulated lipid metabolism underpinning many thrombotic conditions, the role alterations in remains unexplored. Here, we examined plasma lipidome patients compared it those...