Leanne Wallace
A5059913167- Endometriosis Research and Treatment
- Amyotrophic Lateral Sclerosis Research
- Genetic Associations and Epidemiology
- Reproductive System and Pregnancy
- Epigenetics and DNA Methylation
- Neurogenetic and Muscular Disorders Research
- Autism Spectrum Disorder Research
- Neurological diseases and metabolism
- Cancer-related gene regulation
- Parkinson's Disease Mechanisms and Treatments
- Cancer Genomics and Diagnostics
- Endometrial and Cervical Cancer Treatments
- Hemoglobinopathies and Related Disorders
- Assisted Reproductive Technology and Twin Pregnancy
- Gynecological conditions and treatments
- Child Nutrition and Feeding Issues
- Genetic factors in colorectal cancer
- Family Support in Illness
- Estrogen and related hormone effects
- Nuclear Receptors and Signaling
- RNA Research and Splicing
- Family and Disability Support Research
- Opioid Use Disorder Treatment
- Cutaneous Melanoma Detection and Management
- RNA regulation and disease
The University of Queensland
2017-2025
Research Institute for Bioscience and Biotechnology
2022-2023
Autism CRC
2021
Trinity College Dublin
2021
QIMR Berghofer Medical Research Institute
2009-2017
Palo Alto Institute
2011
Kentucky Science Center
2011
An improved understanding of etiological mechanisms in Parkinson's disease (PD) is urgently needed because the number affected individuals projected to increase rapidly as populations age. We present results from a blood-based methylome-wide association study PD involving meta-analysis 229 K CpG probes 1,132 cases and 999 controls two independent cohorts. identify previously unreported epigenome-wide significant associations with PD, including cg06690548 on chromosome 4. demonstrate that...
Autism omics research has historically been reductionist and diagnosis centric, with little attention paid to common co-occurring conditions (for example, sleep feeding disorders) the complex interplay between molecular profiles neurodevelopment, genetics, environmental factors health. Here we explored plasma lipidome (783 lipid species) in 765 children (485 diagnosed autism spectrum disorder (ASD)) within Australian Biobank. We identified lipids associated ASD (n = 8), disturbances 20)...
Genes encoding the opioid receptors (OPRM1, OPRD1 and OPRK1) are obvious candidates for involvement in risk heroin dependence. Prior association studies commonly had samples of modest size, included limited single nucleotide polymorphism (SNP) coverage these genes yielded inconsistent results. Participants current investigation 1459 heroin-dependent cases ascertained from maintenance clinics New South Wales, Australia, 1495 unrelated individuals selected an Australian sample twins siblings...
The genetic contribution to liability for opioid dependence is well established; identification of the responsible genes has proved challenging.To examine association 1430 candidate gene single-nucleotide polymorphisms (SNPs) with heroin dependence, reporting here only 71 SNPs in chromosome 11 cluster (NCAM1, TTC12, ANKK1, DRD2) that include strongest observed associations.Case-control study included 2 control groups (lacking an established optimal group).Semistructured psychiatric...
Abstract Cell-free DNA (cfDNA) is increasingly recognized as a promising biomarker candidate for disease monitoring. However, its utility in neurodegenerative diseases, like amyotrophic lateral sclerosis (ALS), remains underexplored. Existing discovery approaches are tailored to specific context or too expensive be clinically practical. Here, we address these challenges through new approach combining advances molecular and computational technologies. First, develop statistical tools select...
Celiac disease is an autoimmune disorder where intestinal immunopathology arises after gluten consumption. Previous studies suggested that hookworm infection restores tolerance; however, these were small (n = 12) and not placebo controlled.We undertook a randomized, placebo-controlled trial of in 54 people with celiac disease. The 94-week study involved treatment either 20 or 40 Necator americanus third-stage larvae (L3-20 L3-40) placebo, followed by escalating consumption (50 mg/d for 12...
Abstract Background Amyotrophic lateral sclerosis (ALS) is a complex, late-onset, neurodegenerative disease with genetic contribution to liability. Genome-wide association studies (GWAS) have identified ten risk loci date, including the TNIP1 / GPX3 locus on chromosome five. Given analysis data alone cannot determine most plausible gene for this locus, we undertook comprehensive suite of in silico, vivo and vitro address this. Methods The Functional Mapping Annotation (FUMA) pipeline five...
Purpose Children with neurodevelopmental disorders (NDDs) such as autism spectrum disorder (ASD) and attention-deficit hyperactivity (ADHD) face a range of challenges which impact their daily functioning that family. NDDs are often associated significant mental health problems can influence the course. The Improving Outcomes in Mental Health cohort described this article aims to investigate risk factors for persistence severity children NDDs. Participants A total 1084 families (primary...
Genome-wide association studies (GWAS) have now successfully identified important genetic variants associated with many human traits and diseases. The high cost of genotyping arrays in large data sets remains the major barrier to wider utilization GWAS. We developed a novel method which whole blood from cases controls, respectively, is pooled prior DNA extraction for genotyping. demonstrate proof principle by clearly identifying eye color, age-related macular degeneration, pseudoexfoliation...
Do endometriosis risk-associated single nucleotide polymorphisms (SNPs) found at the 12q22 locus have effects on vezatin ( ITALIC! VEZT) expression?The original genome-wide association study (GWAS) SNP (rs10859871), and other newly identified signals, demonstrate strong evidence for cis-expression quantitative trait loci (eQTL) VEZT expression.GWAS several disease-risk associated with endometriosis. The rs10859871 is located within gene. expression altered in endometrium of patients an...
We conducted DNA methylation association analyses using Illumina 450K data from whole blood for an Australian amyotrophic lateral sclerosis (ALS) case-control cohort (782 cases and 613 controls). Analyses used mixed linear models as implemented in the OSCA software. found a significantly higher proportion of neutrophils compared to controls which replicated independent Netherlands (1159 637 The MOMENT model has been shown simulations best account confounders. When combined profile score, 25...
Abstract Maternal postpartum depression (PPD) is a significant public health concern due to the severe negative impact on maternal and child well-being. In this study, we aimed identify genes associated with PPD. To do this, investigated genome-wide gene expression profiles of pregnant women during their third trimester pregnancy tested association perinatal depressive symptoms. A total 137 from cohort University North Carolina, USA were assessed. The main phenotypes analysed Edinburgh...