A5057601943- Cancer Cells and Metastasis
- Retinal Development and Disorders
- Enzyme Catalysis and Immobilization
- Amyotrophic Lateral Sclerosis Research
- Epigenetics and DNA Methylation
- Retinal Imaging and Analysis
- Extracellular vesicles in disease
- RNA Research and Splicing
- Retinal Diseases and Treatments
- Multiple Myeloma Research and Treatments
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Carbohydrate Chemistry and Synthesis
- Effects and risks of endocrine disrupting chemicals
- Biofuel production and bioconversion
- Prostate Cancer Treatment and Research
- Cancer Genomics and Diagnostics
- Corneal surgery and disorders
- Neurogenetic and Muscular Disorders Research
- Autophagy in Disease and Therapy
- Chemical Reactions and Isotopes
- Silymarin and Mushroom Poisoning
- Pharmacological Effects of Medicinal Plants
- Neurological diseases and metabolism
- Coastal and Marine Dynamics
Chinese University of Hong Kong
2025
Prince of Wales Hospital
2025
Dalian Medical University
2024
Chongqing Medical University
2021-2024
Second Affiliated Hospital of Chongqing Medical University
2024
The University of Queensland
2020-2024
Houston Methodist
2023
Methodist Hospital
2023
Tsinghua–Berkeley Shenzhen Institute
2022
Tsinghua University
2022
Significance Because preschool children encounter fewer risks from environmental pressures, we propose that the condition of early-onset high myopia (EOHM) is driven by a genetic predisposition more than factors. In this study, recruited 18 familial trios to decipher using whole-exome sequencing. We identified cluster unique genes linked EOHM, as well mutations in reported genes. Notably, showed both rare inherited and de novo significantly contributed EOHM. Expression profiling ocular...
Significance The polycistronic miR-183/96/182 cluster is highly expressed in various types of terminally differentiating sensory neurons, including photoreceptors. Although miR-182 single-knockout mice do not exhibit significant retinal architecture alterations photoreceptors, deletion miR-183 and miR-96 gives rise to severe defects cone maturation. Long-term follow-up analysis reveals that miR-183/96 ablation results progressive photoreceptor degeneration. Mechanistic studies demonstrate...
Epithelial-mesenchymal transition (EMT) is an essential mechanism of metastasis, including in colorectal cancer. Although EMT processes are often triggered cancer cells by their surrounding microenvironment, how EMT-relevant genes control these not well understood. In multiple types cancers, the transcription factor MEF2D has been implicated cell proliferation, but its contributions to metastasis have addressed. Here, we show overexpressed clinical tissues where high expression correlates...
Familial exudative vitreoretinopathy (FEVR) is a severe hereditary retinal disorder characterized by defects in vascular development. To date, six genes have been reported to be responsible for this disease, including LRP5, FZD4, TSPAN12, NDP, ZNF408, and KIF11. The purpose of our study was investigate the genetic Chinese patients with FEVR through mutational analyses 31 pedigrees.Clinical data peripheral blood were collected from pedigrees FEVR. All coding sequences intron/exon junctions...
ABSTRACT Background Polycystic ovary syndrome (PCOS) is one of the commonest gyneco‐endocrine disorders amongst women reproductive age. Whether PCOS and cardiometabolic traits in patients are associated with shortened telomere length (TL) or relative leukocyte (rLTL) remains unclear. Methods 214 age‐matched were recruited. rLTL was measured an updated quantitative real‐time PCR protocol reported as ΔΔCt between a single‐copy gene encoding β‐globin to normalisation control. A two‐way...
Abstract Background Amyotrophic lateral sclerosis (ALS) is a complex, late-onset, neurodegenerative disease with genetic contribution to liability. Genome-wide association studies (GWAS) have identified ten risk loci date, including the TNIP1 / GPX3 locus on chromosome five. Given analysis data alone cannot determine most plausible gene for this locus, we undertook comprehensive suite of in silico, vivo and vitro address this. Methods The Functional Mapping Annotation (FUMA) pipeline five...
Hepatocellular carcinoma (HCC) is one of the most common and malignant cancers. The HCC incidence gets a strong sexual dimorphism as men are major sufferers in this disaster. Although several studies have uncovered presentative correlation between axis androgen/androgen receptor (AR) incidence, mechanism still largely unknown. Cancer stem cells (CSCs) small subgroup cancer contributing to multiple tumors behaviors, which play an important role oncogenesis various cancers including HCC....
Abstract DNA methylation is an ideal trait to study the extent of shared genetic control across ancestries, effectively providing hundreds thousands model molecular traits with large QTL effect sizes. We investigate cis DNAm QTLs in three European (n = 3701) and two East Asian 2099) cohorts quantify similarities differences architecture populations. observe 80,394 associated mQTLs (62.2% probes significant mQTL) be both while 28,925 (22.4%) are identified only a single ancestry. mQTL sizes...
Purpose: Inherited retinal diseases (IRDs) are a clinically and genetically heterogeneous group of Mendelian disorders that plays crucial role in the etiology blindness across world. Molecular genetic diagnosis IRD remains extremely complex challenging because mutations only detected 40% to 60% cases. In this study, we aimed dissect contributions copy number variations (CNVs) patients. Methods: A total 50 patients were diagnosed with IRD, all whom previously tested negative for pathogenic...
Pancreatic ductal adenocarcinoma (PDAC) is a major cause of cancer-related mortality with dismal prognosis that has changed little over the past few decades. Further understanding molecular pathology PDAC progression urgently required in order to improve patients PDAC. Herein, it was observed trefoil factor 3 (TFF3) expression elevated PDAC, and positively correlated worse overall patient survival outcome. Forced TFF3 promoted oncogenic functions cells vitro including cell proliferation,...
Ocular coloboma is a developmental structural defect of the eye that often occurs as complex ocular anomalies. However, its genetic etiology remains largely unexplored. Here we report identification mutation (c.331C>T, p.R111C) in IPO13 gene consanguineous family with coloboma, microphthalmia, and cataract by combination whole-exome sequencing homozygosity mapping. encodes an importin-B protein has been proven to be associated pathogenesis microphthalmia. We found Ipo13 was expressed cornea,...
To adopt molecular screening in asymptomatic individuals at high risk of developing keratoconus as a combinative approach to prevent subclinical patients from post-refractive surgery progressive corneal ectasia.In this study, 79 Chinese and nine Greek families with were recruited, including 91 clinically diagnosed well their but assumptive high-risk first-degree relatives based on underlying genetic factor. Mutational VSX1, TGFBI, ZEB1 genes full clinical assessment Pentacam Scheimpflug...
Cellular diversity is a product of evolution acting to drive divergent regulatory programs from common genome. Here, we use cross-cell-type epigenetic conservation gain insight into the impact selective constraints on genome function and phenotypic variation. By comparing chromatin accessibility across hundreds diverse cell-types, identify 1.4% human safeguarded by conserved domains facultative heterochromatin, which term regions under cellular constraint. We calculate single-base resolution...
The phytopathogen Pseudomonas syringae pv. tabaci 11528 (P. 11528), causing wild-fire disease in soybean and tobacco plants, processes PsyI-PsyR quorum-sensing (QS) system, which PsyI is the N-(3-oxo-hexanoyl)-homoserine lactone (3OC6-HSL) synthase. In comparison to P. AHL-deficient mutant, 845 3OC6-HSL-dependent genes were identified using RNA sequencing (RNA-seq) mutant grown with exogenous 3OC6-HSL transition from exponential stationary phase, many of them associated virulence, negatively...
Abstract Durable, highly efficient, and economic sound electrocatalysts for CO electrooxidation (COE) are the emerging key wide variety of energy solutions, especially fuel cells rechargeable metal−air batteries. Herein, we report novel system nickel−aluminum double layered hydroxide (NiAl-LDH) nanoplates on carbon nanotubes (CNTs) network. The formulation such complexes was to be induced through assistance gold nanoparticles in order form dual-metal active sites so as create a extended...
The kinetic resolution of (R,S)-1-(4-chlorophenyl)ethylamine was accomplished using a commercial lipase from Candida antarctica (Novozym 435). performance this investigated for the enantioselective amidation (R,S)-1-(4-chlorophenyl)ethylamine, leaving target product (S)-1-(4-chlorophenyl)ethylamine in its unreacted form. effects various types solvents and an acyl donor, molar ratio substrate to reaction temperature were studied. optimum conditions found result with methyl 2-tetrahydrofuroate...
Background: The dysregulation of long non-coding RNAs is a frequent finding in glioblastoma (GBM) and considered as crucial mechanism contributing to GBM oncogenesis progression. biological roles underlying mechanisms action UBA6 antisense RNA 1 (UBA6-AS1) have been rarely investigated. Therefore, the aim present study was investigate detail role UBA6-AS1 modulation malignant properties explore possible mechanism(s). Methods: expression determined via reverse transcription-quantitative PCR....
BACKGROUND: In our clinical practice, we observed that some osteoporotic vertebral compression fracture patients undergoing augmentation exhibited pain in the iliac crest region. This aligned with diagnostic criteria for superior cluneal neuralgia (SCN) and affected treatment satisfaction. OBJECTIVE: study aims to clinically observe a hospital setting analyze etiology risk factors associated SCN. STUDY DESIGN: Retrospective cohort study. SETTING: Inpatient population of single center....
Abstract In this study, a newly isolated strain screened from the indoxacarb‐rich agricultural soils, Bacillus cereus WZZ006, has high stereoselectivity to racemic substrate 5‐chloro‐1‐oxo‐2,3‐dihydro‐2‐hydroxy‐1 H ‐indene‐2‐carboxylic acid methyl ester. ( S )‐5‐chloro‐1‐oxo‐2,3‐dihydro‐2‐hydroxy‐1 ester was obtained by bio‐enzymatic resolution. After 36‐hour hydrolysis in 50‐mM under optimized reaction conditions, e.e . s up 93.0% and conversion nearly 53.0% with E being 35.0. Therefore, B...